DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and MEE27

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_181034.1	Gene:	MEE27 / 818053	AraportID:	AT2G34880	Length:	806	Species:	Arabidopsis thaliana

Alignment Length:	1046	Identity:	272/1046 - (26%)
Similarity:	403/1046 - (38%)	Gaps:	352/1046 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 PTPAPTGHKKSVHTQPHSSNKFDQGKNEEFHFDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKC 188
            |..:|...|......|.:..:.|.|           |.|||.||:|||::.||||.|||.:||..
plant    35 PPSSPYHPKVLARWDPANEKRPDIG-----------EAPVFHPTSEEFEDTLAYIEKIRPLAESF 88

  Fly   189 GIAKILPPATWSPPFAVDVDKLRFVPRVQRLNELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVE 253
            ||.:|:||:.||||                                     ..|:|.|:
plant    89 GICRIVPPSNWSPP-------------------------------------CRLKGDSI------ 110

  Fly   254 RKALDLYTLHRIVQEEGGMEQTTKDRKWAKVANRMQYPSSKSVGATLKAHYERILHPFEVYTSGK 318

plant   111 ----------------------------------------------------------------- 110

  Fly   319 VLGPTPTSSGSGSTPVKLEDGGGTDYKAHEIPTRQQIAPPNETNTRRSKRFGNSNASCGLSGVTP 383
                                     :|....|||.|
plant   111 -------------------------WKNKNFPTRVQ----------------------------- 121

  Fly   384 TTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALIVDPLMK 448
                    ||          |||.     |.|  |:...|   .:|..:|:|            |
plant   122 --------FV----------DLLQ-----NRG--PVKKKT---PKGRKRKRG------------K 146

  Fly   449 YICHIC---NRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGFE 510
            |...:.   ..|.|.:|:                    |.||             :..:|.||||
plant   147 YSRTVAPKKRNGSVSKSV--------------------STPK-------------ATEEENFGFE 178

  Fly   511 QAEREYTLQQFGQMADQFKQEYFRKPVHL--VPTEMVEREFWRIVSSIDEDVTVEYGADLHTMDH 573
            ... |:||::|.:.|..||..||.:..::  ...|.:|.|:|||:.....:|.|.||.||.....
plant   179 SGP-EFTLEKFEKYAQDFKDSYFERKDNVGDPSVEEIEGEYWRIIEKETNEVKVLYGTDLENPIL 242

  Fly   574 GSGF------PTKSSLYLLPGDQE-YAESSWNLNNLPLLEDSILGHINADISGMNAPWMYVGMCF 631
            ||||      ||:.:      |.: |..|.||||||..|:.|:|...:.:|||:..||:||||||
plant   243 GSGFSKGVKIPTRRN------DMDKYISSGWNLNNLARLQGSLLSFEDCEISGVQVPWLYVGMCF 301

  Fly   632 AAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLHQLVTIMNP 696
            :.||||.||:..||:||.|:||||.|||||||.|...|:.|::..|:||..||||||:|||..:|
plant   302 STFCWHVEDNHLYSLNYHHFGEPKVWYGVPGSHATGLEKAMRKHLPDLFDEQPDLLHELVTQFSP 366

  Fly   697 NILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHYSMLRR 761
            .||.|..|||:|..|:|||:|:|||||||:|||.|:|.|||||.||.|||..|:..|..||...|
plant   367 TILKNEGVPVYRAVQNAGEYVLTFPRAYHSGFNCGFNCAEAVNVAPVDWLAHGQNAVEIYSQETR 431

  Fly   762 FCVFSHDELVCKMALEPAK----------LTFGIATACYID--MAEMVDTEKKLRKSLLEWGVTR 814
            ....|||:::...|.|..|          ..|.....|..|  :.:.::...::.:..:|
plant   432 KTSLSHDKILLGAAFEAVKSLSAHGEDNTKRFSWKRFCGKDGIITKAIEARLRMEEKRIE----- 491

  Fly   815 AERRAFELVNDD-------ERHCQECNTTCFLSAVACE-CND-KLIVCLRHYTVLCGCAPEKHTL 870
            |....|.||..|       ||.|..|.:...|||..|: |:. :...|.:|  .:|.|..:...:
plant   492 ALGNGFSLVKMDKDFDSNCERECISCFSDLHLSATGCKNCSSLEEYGCTKH--DICSCEGKDRFI 554

  Fly   871 IYRYTLDEMPLMLQKLKVKAHSFERWLSRCRDIVDAHTPTS--------VTLQELQELCKEAETK 927
            ..|||:||:..:::.|:.::...:.|||:   :::..:.|.        |..:::||.|.:...:
plant   555 FLRYTIDELSSLVRALEGESDDLKAWLSK---VMEGCSETQKGESSGIIVKEKQVQEECFDLNGE 616

  Fly   928 KFPSSLLIDR---LNAAAVEAEKC---VTVIQQLGINKVRTRSDHNQEAAQYKLTMEELEL--FV 984
            ...||.:.:.   ::.||...|..   ..|:.:|..||........:...::....:.:.:  :|
plant   617 CNKSSEICEDASIMDLAAYHVEPINLGFLVVGKLWCNKHAIFPKGFKSRVKFYNVQDPMRISYYV 681

  Fly   985 QEIDNLCCIIDEGASVRELLVLGKQFVERSESQLQLSLESLEESELETLINEGSSLRIELQQLDL 1049
            .|      |:|.|       :||..|           ..:||||:     :|..|.....:..::
plant   682 SE------IVDAG-------LLGPLF-----------KVTLEESQ-----DESFSYASPQKCWEM 717

  Fly  1050 LQKRLKQCKWYKRSQGLRETSSKLTYQDVKNLLHIAAADL-DPTDPYVDKEMRKLQQIGADIEAW 1113
            :..|:|:       :.:|.::.|   |||..|..|....: ....|::.:....|......:|.|
plant   718 VLLRVKE-------EIMRRSNQK---QDVHMLESIDGLKMFGFRSPFIVQATEALDPNHGQVEYW 772

  Fly  1114 ESQAAK 1119
            ..:..|
plant   773 NHKNEK 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	24/40 (60%)
		ARID	227..312	CDD:198082	3/84 (4%)
		PHD1_Lid_like	450..495	CDD:277078	6/47 (13%)
		JmjC	624..740	CDD:202224	73/115 (63%)
		zf-C5HC2	830..882	CDD:280996	16/53 (30%)
		PLU-1	896..1229	CDD:285609	45/241 (19%)
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
MEE27	NP_181034.1	JmjN	60..101	CDD:128818	24/40 (60%)
		JmjC	294..410	CDD:202224	73/115 (63%)
		zf-C5HC2	514..566	CDD:280996	16/53 (30%)
		FYRN	643..687	CDD:128814	7/49 (14%)
		FYRC	693..781	CDD:197781	21/112 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	175	1.000	Domainoid score	I1097
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820