DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment lid and kdm5c

DIOPT Version :9

Sequence 1:NP_001245908.1 Gene:lid / 33837 FlyBaseID:FBgn0031759 Length:1838 Species:Drosophila melanogaster
Sequence 2:NP_001072719.1 Gene:kdm5c / 780176 XenbaseID:XB-GENE-1033025 Length:1506 Species:Xenopus tropicalis


Alignment Length:1605 Identity:671/1605 - (41%)
Similarity:917/1605 - (57%) Gaps:203/1605 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 FDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRL 219
            |..|.|||||.||.||||:||.||:|||.||||.||.||.||..|.|||||:||...|.||:|||
 Frog     9 FVPPAECPVFEPTWEEFKDPLGYIAKIRPIAEKSGICKIRPPVDWQPPFAVEVDNFHFTPRIQRL 73

  Fly   220 NELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKV 284
            |||||:||||||:|||||||||:||||||||.|||:.||||:|::|||||||.|...::|:||:|
 Frog    74 NELEAETRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLNKIVQEEGGYEPICRERRWARV 138

  Fly   285 ANRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEI 349
            |.||.|||.|::|:.|::|||||::||.:|.||      .........|....:....:||.|.|
 Frog   139 AQRMGYPSGKNLGSLLRSHYERIIYPFHMYQSG------ANMVDYRERPRYDNEEKDKEYKPHSI 197

  Fly   350 PTRQQIAPPNETN-TRRSKRF-----GNSNASCGLSGVTPTTKPSAGVFVKTETKEEFKRDLLSS 408
            |.||.:.|...|: .||:||.     .||:.:...|.....|.||   :.:...::..|...|..
 Frog   198 PLRQSVQPSKITSYGRRAKRLTQEDPENSDPAAQSSSQPTETSPS---WPEPTVEDIEKNPELKK 259

  Fly   409 FNAVNSGGSPLATGTTANTRGASQKKGGE----PPALIV-------------------------- 443
            .....:|...:..|..|..:.. :||..:    ||.|::                          
 Frog   260 LQIYGAGPKMMGLGLMAKNKNL-RKKDSDIPECPPTLVIKEEVPVEGRGEPGEVQVHVKQERSLS 323

  Fly   444 -DPLMK-------------------YICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKG 488
             :|..|                   |||.||:|||.::.:||||||||:||||||||||...|||
 Frog   324 PEPCTKMTMRLRRNTITNSNQFVDSYICRICSRGDDDDRLLLCDGCDDNYHTFCLLPPLPEPPKG 388

  Fly   489 EWLCPRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIV 553
            .|.||:||:.|..:|.||||||||.||:|||.||:|||.||.:||..|||:||||:||:||||:|
 Frog   389 IWHCPKCVMAECKRPPEAFGFEQATREFTLQSFGEMADAFKADYFNMPVHMVPTELVEKEFWRLV 453

  Fly   554 SSIDEDVTVEYGADLHTMDHGSGFP-TKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADI 617
            :||:|||||:||||:|:.:.||||| ......|.|.::.||.|.||||.:|:||.|:|.||||||
 Frog   454 NSIEEDVTVQYGADIHSKEFGSGFPMLDGKTELSPEEKAYATSGWNLNVMPVLEQSVLCHINADI 518

  Fly   618 SGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSS 682
            |||..||:||||.|:|||||.|||||||||||||||||||||||.|.|||.|:.||:..||||.|
 Frog   519 SGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSSAAEQLEDVMKKLTPELFES 583

  Fly   683 QPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLK 747
            ||||||||||:||||.||.:.|||.||:|.|||||||||||||:||||||||||||||..||||.
 Frog   584 QPDLLHQLVTLMNPNTLMAHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLP 648

  Fly   748 MGRECVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGV 812
            .||:|:.||..|||:|||||:||:||||..|.:|...:|.|.:.:|..:|..|::|||:|||.||
 Frog   649 AGRKCIEHYRRLRRYCVFSHEELICKMAACPERLDMSLAAAVHKEMFLLVQEERRLRKTLLEQGV 713

  Fly   813 TRAERRAFELVNDDERHCQECNTTCFLSAVAC-ECNDKLIVCLRHYTVLCGCAPEKHTLIYRYTL 876
            |.|||.||||:.||||.||:|.|||||||:|| :|...| |||.|...||.|.|.:..|.|||||
 Frog   714 TEAEREAFELLPDDERQCQKCKTTCFLSALACYDCPQGL-VCLYHIEDLCQCPPSRQYLRYRYTL 777

  Fly   877 DEMPLMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLIDRLNAA 941
            ||:|.||.|||.:|.||:.|.::.|..::....|...|.||:.|..||..|||..:..:..|..:
 Frog   778 DELPAMLHKLKGRAESFDTWSNKVRLAIELDGKTKKELVELKTLEAEAFEKKFVENEHLQLLRGS 842

  Fly   942 AVEAEKCVTVIQQ-LGINKV-RTRSDHNQEAAQYKLTMEELELFVQEIDNLCCIIDEGASVRELL 1004
            ..|.|.|:...:: ||.::. |:.|.        .:::|.|...|:.|.::.|::.:.:.::.| 
 Frog   843 IQEVESCIAEAKKVLGFSQANRSHST--------VISLEGLIKLVKRIQSVPCVVPQLSQLQCL- 898

  Fly  1005 VLGKQFVERSESQLQLSLESLEE--SELETLINEGSSLRIELQQLDLLQKRLKQCKWYKRSQGLR 1067
               ::..|..:.:.|.||.:|..  |:|..::....:|.:|:..:..:::.|:|.:|.:|.:...
 Frog   899 ---QEEAETLQEEAQKSLLTLSNSTSQLREVLERCQALTVEVPAVRQIERHLRQGEWLERVRTAL 960

  Fly  1068 ETSSKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHELGE 1132
            .:....|.|::::||  ..|:.....|.|:|...:||::.:....|| :.|:......::|....
 Frog   961 SSGRSGTLQEMRSLL--KEAEEVAESPAVEKARSELQELISIALRWE-EKAQMCLEARKKHPPAM 1022

  Fly  1133 IEQFLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQNNHVTYCHTLEAMIERGLNIPIQLE 1197
            :|..:|.|..|..|:|:...||:||.|||.|...||::|..:|......||.::..|.::|:::|
 Frog  1023 LEAIIKEAEHIPVQLPNTLSLKEALCKARAWSADVEEIQSGDHYPCLDDLEGLVAVGRDLPVKME 1087

  Fly  1198 ELSRMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINIDSDLKPRFQDDFLKE----- 1257
            ||.:::..:.:||.|::..:..||||.:.|||||||.|.:|..: |:..:.|::.:  ||     
 Frog  1088 ELHQLEVQVAAAHSWREKASKTFLKKNSCYTLLEVLCPSADVCS-DTGKRSRWKKE--KEQGLYR 1149

  Fly  1258 -------------KNPAEIVASFKHAEEQELLDMRELRRQNMNKNPMRDMFCLCKSEFRNLMFNC 1309
                         ::|..||.:||..|::|...:  ||.:.||.:..|...|:|......||..|
 Frog  1150 SDIESLGLSAQDLRDPGCIVLAFKEGEQKEKAGI--LRLRAMNSSLERGCVCVCGEPPDELMLRC 1212

  Fly  1310 QLCRDWFHEDCVPPPSATNQNGIVNGGSGPGTNRPKW----LCPSCVRSKRPRLETILPLLVQLQ 1370
            :||:|.||..|||.|..:|..|   ..:.|.....:|    ||..||||:||||:|||.|||.||
 Frog  1213 ELCQDLFHGLCVPSPRLSNHRG---AHTMPSLIWWEWDSRFLCSLCVRSRRPRLQTILSLLVALQ 1274

  Fly  1371 QLPIRLPEDEALRCLAERAMNWQDRARKALSSPDVSAAQEAIMAQQQQKRRSEGGAGVGNISSPR 1435
            :||:||||.|||:||.||||:||||||:.|::|::|:|..| :|:::||.:.       :...|:
 Frog  1275 KLPVRLPEGEALQCLTERAMSWQDRARRVLATPEISSAATA-LAERRQKMQQ-------HCKDPQ 1331

  Fly  1436 KPRRRGSLTKEASGSTESDADDDDDEDECRLRIVEDNFSNDEDEPRTAPATSTVNSDLLKLLSDS 1500
            ..|.  :...|.:...:.:.|...:...|.:          .|....|.....:....:..||..
 Frog  1332 ALRE--TTRNEQNPVPQENGDCHTENGTCAM----------PDLDAMAALLPRLEKTAILELSLG 1384

  Fly  1501 EIENLLDLMMEGDLLEVSLDETQELWRIL--ETMP-----PTLLQAEAMERVVQYMQRQRQQHTN 1558
            ....|.|||:|||||||||:|...:||:|  ..:|     .||::.|..||     :..||:..:
 Frog  1385 SRALLEDLMLEGDLLEVSLEEEASIWRLLLASQVPCIERLRTLIEIERCER-----RLARQKGKD 1444

  Fly  1559 PLPTSGAEDSNDSLMVQNSPNSNSNSGGATGSASNSGRNKKRRSNDTGGNSAVPRKKQSTPKQTP 1623
            |                                   .:.|||||....|.|     ....||:..
 Frog  1445 P-----------------------------------EKRKKRRSERGDGYS-----PPILPKEEL 1469

  Fly  1624 GKKGSAAAARKSDAKASPAASTTPGADADAENKQANGGNTNSSTG 1668
            |.|..     :||.:|....|     |.::..|   ||:..|..|
 Frog  1470 GPKRC-----RSDIRAQETLS-----DKESPRK---GGSECSQNG 1501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lidNP_001245908.1 JmjN 160..201 CDD:128818 29/40 (73%)
ARID 227..312 CDD:198082 57/84 (68%)
PHD1_Lid_like 450..495 CDD:277078 31/44 (70%)
JmjC 624..740 CDD:202224 93/115 (81%)
zf-C5HC2 830..882 CDD:280996 31/52 (60%)
PLU-1 896..1229 CDD:285609 86/336 (26%)
PHD2_KDM5A 1295..1351 CDD:277079 20/59 (34%)
PHD3_KDM5A_like 1755..1805 CDD:277083
kdm5cNP_001072719.1 JmjN 14..55 CDD:128818 29/40 (73%)
BRIGHT 81..171 CDD:128777 59/89 (66%)
PHD_SF 350..395 CDD:304600 31/44 (70%)
JmjC 525..641 CDD:202224 93/115 (81%)
zf-C5HC2 731..783 CDD:280996 31/52 (60%)
PLU-1 796..1119 CDD:285609 86/337 (26%)
PHD2_KDM5C_5D 1198..1255 CDD:277081 20/59 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 218 1.000 Domainoid score I2602
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1253 1.000 Inparanoid score I176
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D664180at2759
OrthoFinder 1 1.000 - - FOG0000761
OrthoInspector 1 1.000 - - otm47834
Panther 1 1.100 - - LDO PTHR10694
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R628
SonicParanoid 1 1.000 - - X397
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
88.190

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