DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and Jarid2

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	XP_017456196.1	Gene:	Jarid2 / 681740	RGDID:	1591663	Length:	1281	Species:	Rattus norvegicus

Alignment Length:	991	Identity:	245/991 - (24%)
Similarity:	396/991 - (39%)	Gaps:	248/991 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKTEADNTTAAN---SGGGGVGSGTSSGGGASANGTATP--------ARRLRTRNSTGNGTNS 54
            :|.|:|:.|.....   |.||...|...:..|..|:....|        .|:||      .|..:
  Rat   422 ISGKSESSNAKTRKQVLSLGGASTSTAPAASGLKASSRLNPKSCTKEVGGRQLR------EGLRN 480

  Fly    55 GSESVKKSNANDEPSTPVTPAGATGSHTHAPPGISPAV------------MERPMPSVPMNHASS 107
            ....::::...|:..:|......|.....||...:.|.            .|.|..|:..|....
  Rat   481 SKRRLEEAQQVDKQQSPPKKMKGTAGIAEAPGRKASAASGEKSLLNGHVKKEVPERSLERNRPKR 545

  Fly   108 SVSASKKYHNSCPHPTPTPAPTGHKKSVHTQPHSSNK--FDQGKNE----EFHFDTPPECPVFRP 166
            : :|.|.......|......|..::.:  :||.||:|  ..|||.|    :..:....|.||.||
  Rat   546 A-AAGKNMLGKQAHGKSEGTPCENRST--SQPESSHKPHDPQGKPEKGSGKSGWAAMDEIPVLRP 607

  Fly   167 TTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRLNELEAKTRVKLN 231
            :.:||.:||.||..:|:..||.|:.:::||..|.|...:: |::|||.::|.:::|..:....:.
  Rat   608 SAKEFHDPLIYIESVRAQVEKYGMCRVIPPPDWRPECKLN-DEMRFVTQIQHIHKLGRRWGPNVQ 671

  Fly   232 FLDQIAKFWELQGSSL-KIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKVANRMQYP-SSK 294
            .|..|.|....||.:: ::|::....|||....|::.|.|||:|.|..:||.|:|:.::.| :::
  Rat   672 RLACIKKHLRSQGITMDELPLIGGCELDLACFFRLINEMGGMQQVTDLKKWNKLADMLRIPKTAQ 736

  Fly   295 SVGATLKAHYERILHPF-------------EVYTSGKVL----GPTPTSSGSGSTPVKLEDGGGT 342
            ...|.|:..|.:.|..:             ||....::|    ||             ||  |.|
  Rat   737 DRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGP-------------LE--GHT 786

  Fly   343 D---YKAHEIPTRQQIAPPNETNTRRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEFKRD 404
            :   :|.|.:|                 ||...|..  :.||||...      .:::.||
  Rat   787 ENDHHKFHSLP-----------------RFEPKNGL--IHGVTPRNG------FRSKLKE----- 821

  Fly   405 LLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALIVDPLMKYICHICNRGDVEESMLLCDGC 469
                     .|.:||.||   ..|..:|:|                 .:....:.::.:|
  Rat   822 ---------VGRAPLKTG---RRRLFAQEK-----------------EVVKEEEEDKGVL----- 852

  Fly   470 DDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFR 534
            ||.|                    :|:.:              .|..:|..|.:.|.......|.
  Rat   853 DDFY--------------------KCIYK--------------GRSVSLTTFYRTARNIMNMCFS 883

  Fly   535 KPVHLVPTEMVEREFWRIVSSIDEDVTVEYGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNL 599
            |  ...|.| :|:|:||:|...|..|.|..| .:.|..||||||...|       :.::...|||
  Rat   884 K--EPAPAE-IEQEYWRLVEEKDCHVAVHCG-KVDTNTHGSGFPVGKS-------EPFSRHGWNL 937

  Fly   600 NNLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCW-HNEDHWSYSINYLHWGEPKTWYGVPGS 663
            ..||....|||.|:.| :.|:..||:.:||.|:..|| .:::|..| |:|||.|....||.:|..
  Rat   938 TVLPNNTGSILRHLGA-VPGVTIPWLNIGMVFSTSCWSRDQNHLPY-IDYLHTGADCIWYCIPAE 1000

  Fly   664 CAEQFEETMKQAAPELFSSQPDLLHQLV--------------TIMNPNILMNNRVPVFRTDQHAG 714
            ...:.|               |::|.|:              .:::|.:|....:.|.||.|.:|
  Rat  1001 EENKLE---------------DVVHTLLQGNGTPGLQMLESNVMISPEVLCKEGIKVHRTVQQSG 1050

  Fly   715 EFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHYSMLRRFCV--FSHDELVCKMALE 777
            :||:.||.::.:....|||.:|.|:||...|..||.|...  .|.||...  ||.::|:.::|..
  Rat  1051 QFVVCFPGSFVSKVCCGYNVSETVHFATTQWTSMGFETAK--EMKRRHIAKPFSMEKLLYQIAQA 1113

  Fly   778 PAKLTFG--IATACYIDMAEMVDTEKKLRKSLLEWGVTRAER-----------------RAFELV 823
            .||...|  ::|...: :.|:.|||.:.|:.|.|.|:..:.|                 |.:..:
  Rat  1114 EAKKENGPTLSTISAL-LDELRDTELRQRRQLFEAGLHSSARYGSHDGSSAVADGKKKPRKWLQL 1177

  Fly   824 NDDERHCQECNTTCFLSAVACECNDKLIVC----LRHYTVLCGCAPEKHTLIYRYTLDEMPLMLQ 884
            ...||.||.|...|:||.|..| |:.::.|    |||......|...|  |:|||..:::..::.
  Rat  1178 ETSERRCQICQHLCYLSMVVQE-NENVVFCLECALRHVEKQKSCRGLK--LMYRYDEEQIISLVN 1239

  Fly   885 KLKVKAHSFERWLSRC 900
            ::..|.......:..|
  Rat  1240 QICGKVSGKHGGIENC 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	18/40 (45%)
		ARID	227..312	CDD:198082	25/99 (25%)
		PHD1_Lid_like	450..495	CDD:277078	4/44 (9%)
		JmjC	624..740	CDD:202224	36/130 (28%)
		zf-C5HC2	830..882	CDD:280996	19/55 (35%)
		PLU-1	896..1229	CDD:285609	1/5 (20%)
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
Jarid2	XP_017456196.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920