DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and KDM5A

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_001036068.1	Gene:	KDM5A / 5927	HGNCID:	9886	Length:	1690	Species:	Homo sapiens

Alignment Length:	1825	Identity:	728/1825 - (39%)
Similarity:	997/1825 - (54%)	Gaps:	349/1825 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 FDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRL 219
            |..|||||||.|:.|||.:||::|.:||.:|||.||.||.||..|.||||.:|...||.||||||
Human    13 FVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKSFRFTPRVQRL 77

  Fly   220 NELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKV 284
            |||||.|||:|:||||:|||||||||:||||:||||.||||.|.:||..:||.|..||::||:||
Human    78 NELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEMVTKEKKWSKV 142

  Fly   285 ANRMQYPSSKSVGATLKAHYERILHPFEVYTSG-KVLG-------------PTPTSSGSGSTPVK 335
            .:|:.|...|..|:.||:||||||:|:|::.|| .::|             |...|:.:.::|
Human   143 GSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMGVQMPNLDLKEKVEPEVLSTDTQTSP-- 205

  Fly   336 LEDGGGTDYKAHEIPTRQQIAPPNETNTRRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEE 400
             |.|           ||..|.|   ..|||.|                |...|..|...||.|:
Human   206 -EPG-----------TRMNILP---KRTRRVK----------------TQSESGDVSRNTELKK- 238

  Fly   401 FKRDLLSSFNAVNSGGSPLATGTTANTRGAS---------------------QKKGGEPPALIVD 444
                 |..|     |..|...|....|:...                     |:||    .|.|:
Human   239 -----LQIF-----GAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKG----TLSVN 289

  Fly   445 PLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGF 509
            .:..|:|..|.||:.|:.:|||||||||||||||:|||..:|||:|.||:||.||.|||:|||||
Human   290 FVDLYVCMFCGRGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGF 354

  Fly   510 EQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVSSIDEDVTVEYGADLHTMDHG 574
            |||.||||||.||:|||.||.:||..|||:||||:||:||||:||||:|||.||||||:.:.|.|
Human   355 EQAVREYTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFG 419

  Fly   575 SGFPTKSS-LYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCWHN 638
            ||||.|.. ..:||.::|||.|.|||||:|:||.|:|.|||.|||||..||:||||||::||||.
Human   420 SGFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHI 484

  Fly   639 EDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLHQLVTIMNPNILMNNR 703
            |||||||||||||||||||||||...|||.||.|::.|||||.||||||||||||||||:||.:.
Human   485 EDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHG 549

  Fly   704 VPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHYSMLRRFCVFSHD 768
            |||:||:|.|||||:|||||||:||||||||||||||..||||.:||:|||||..|||.|||||:
Human   550 VPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHE 614

  Fly   769 ELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAERRAFELVNDDERHCQEC 833
            ||:.|||.:|..|..|:|.....::..|.:.|.:||:|:::.||..:|...||||.||||.|..|
Human   615 ELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVLMSEEEVFELVPDDERQCSAC 679

  Fly   834 NTTCFLSAVACECNDKLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMPLMLQKLKVKAHSFERWLS 898
            .|||||||:.|.||.:.:|||.|.|.||.|..:|..|.|||.|:::|.:|..:||:|.|::.|:|
Human   680 RTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVS 744

  Fly   899 RCRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLIDRLNAAAVEAEKCVTVIQQLGINKVRTR 963
            |..:.:.|:......|.||:.:.::||.:|:|.:.|..:|..|..|||.|.:|.|.|...|.:.|
Human   745 RVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCASVAQLLLSKKQKHR 809

  Fly   964 SDHNQEAAQYKLTMEELELFVQEIDNLCCIIDEGASVRELLVLGKQFVERSESQLQLSLESLEES 1028
            ...:....:.|||:|||:.|||::.:|.|:|.:...|:.||...::|.||::..:.  .|:.:.|
Human   810 QSPDSGRTRTKLTVEELKAFVQQLFSLPCVISQARQVKNLLDDVEEFHERAQEAMM--DETPDSS 872

  Fly  1029 ELETLINEGSSLRIELQQLDLLQKRLKQCKWYKRSQGLRETSSKLTYQDVKNLLHIAAADLDPTD 1093
            :|:.||:.||||.:||.:|..|::.|:|.:|....:.......::|...:|.|:. :...|.|..
Human   873 KLQMLIDMGSSLYVELPELPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLID-SGVGLAPHH 936

  Fly  1094 PYVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHELGEIEQFLKSASDINGQVPSHGLLKDALR 1158
            . |:|.|.:||::....|.|| :.||...:...:|.:..:|..:..|.:|...:|:...||:||:
Human   937 A-VEKAMAELQELLTVSERWE-EKAKVCLQARPRHSVASLESIVNEAKNIPAFLPNVLSLKEALQ 999

  Fly  1159 KAREWLRAVEQLQQNNHVTYCHTLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDNTACAFLKK 1223
            |||||...||.:|..::..|...||::..:|..||::||.|.:::..:.:|..|::.|...||||
Human  1000 KAREWTAKVEAIQSGSNYAYLEQLESLSAKGRPIPVRLEALPQVESQVAAARAWRERTGRTFLKK 1064

  Fly  1224 GTFYTLLEVLMPRSDAINI---------------------DSDLKP--RFQDDFLKEKNPAEIVA 1265
            .:.:|||:||.||:| |.:                     |.||:|  ..::...:.::.|.:||
Human  1065 NSSHTLLQVLSPRTD-IGVYGSGKNRRKKVKELIEKEKEKDLDLEPLSDLEEGLEETRDTAMVVA 1128

  Fly  1266 SFKHAEEQELLDMRELRRQNMNKNPMRD-----MFCLCKSEFRNLMFNCQLCRDWFHEDCVPPPS 1325
            .||..|::|:..|..||..|:.|..|.|     .||:|:......|..|:||:||||..|||.|.
Human  1129 VFKEREQKEIEAMHSLRAANLAKMTMVDRIEEVKFCICRKTASGFMLQCELCKDWFHNSCVPLPK 1193

  Fly  1326 ATNQNGIVNGGSGPGTNRPKWLCPSCVRSKRPRLETILPLLVQLQQLPIRLPEDEALRCLAERAM 1390
            :::|    ..||.......|:|||.|:||:||||||||.|||.||:||:||||.|||:||.||||
Human  1194 SSSQ----KKGSSWQAKEVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAM 1254

  Fly  1391 NWQDRARKALSSPDVSAA-------------------QEAIMAQQQQK--------------RRS 1422
            :||||||:||::.::|:|                   .|.|::.:.||              ::|
Human  1255 SWQDRARQALATDELSSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQS 1319

  Fly  1423 EGGAGVGNISSPRKPRRRGSLTKEASGSTESDADDD-------DDEDECRLR---IVEDNFSNDE 1477
            .....|.::||  .||:......|     |:|:|:|       |.:|...::   .:|.|...||
Human  1320 AFNRVVSSVSS--SPRQTMDYDDE-----ETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDE 1377

  Fly  1478 D----------------------------------------EPRTAP-ATSTVNSDLLKLLSDSE 1501
            :                                        :||.:| ...::...:|:|...::
Human  1378 EIPIKSEEVVTHMWTAPSFCAEHAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAK 1442

  Fly  1502 IENLLDLMMEGDLLEVSLDETQELWRILE-TMPPT------LLQAEAMERVVQYMQRQRQQHTNP 1559
            .: |.:|||.||||||||||||.:||||: |.||:      :::.::||.             .|
Human  1443 AQ-LEELMMVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSMEE-------------KP 1493

  Fly  1560 LPTSGAEDSNDSLMVQNSPNSNSNSGGATGSASNSGRNKKRRSNDT------GGNSAVPRKKQST 1618
            |...|.:.|.                          :.:||:....      |...:...||...
Human  1494 LKVKGKDSSE--------------------------KKRKRKLEKVEQLFGEGKQKSKELKKMDK 1532

  Fly  1619 PKQTPGKKGSAAAARKSDAKASPAASTTPGADADAE-NKQANGGNTNSSTGSGGGNSATTTPTPG 1682
            |             ||...|.        |||...| ||.|.                   ....
Human  1533 P-------------RKKKLKL--------GADKSKELNKLAK-------------------KLAK 1557

  Fly  1683 STHKKRKRTSTTATNNNNNNNNNSTNNSNSSTNLNSNTTSGQGAATGGNNATGGQKKHAQR---- 1743
            ...:|:|:....|                :...|...:|               :||..::
Human  1558 EEERKKKKEKAAA----------------AKVELVKEST---------------EKKREKKVLDI 1591

  Fly  1744 ----SQQAAQEDDEEE--CRAENCHKPTGREVDWVQCDGGCNEWFHMYCVGLNRSQIKPDDDYIC 1802
                ....|:|.|:|.  |.|:||.:|...:||||||||||:||||..|||:: .::..::||||
Human  1592 PSKYDWSGAEESDDENAVCAAQNCQRPCKDKVDWVQCDGGCDEWFHQVCVGVS-PEMAENEDYIC 1655

  Fly  1803 IRCTK 1807
            |.|.|
Human  1656 INCAK 1660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	24/40 (60%)
		ARID	227..312	CDD:198082	53/84 (63%)
		PHD1_Lid_like	450..495	CDD:277078	29/44 (66%)
		JmjC	624..740	CDD:202224	93/115 (81%)
		zf-C5HC2	830..882	CDD:280996	27/51 (53%)
		PLU-1	896..1229	CDD:285609	105/332 (32%)
		PHD2_KDM5A	1295..1351	CDD:277079	22/55 (40%)
		PHD3_KDM5A_like	1755..1805	CDD:277083	27/51 (53%)
KDM5A	NP_001036068.1	JmjN	18..59	CDD:128818	24/40 (60%)
		ARID	85..170	CDD:198082	53/84 (63%)
		PHD1_KDM5A	295..343	CDD:277075	31/47 (66%)
		GSGFP motif. /evidence=ECO:0000250\|UniProtKB:Q3UXZ9	419..423		3/3 (100%)
		JmjC	470..586	CDD:202224	93/115 (81%)
		zf-C5HC2	676..728	CDD:280996	27/51 (53%)
		PLU-1	741..1070	CDD:285609	105/333 (32%)
		PHD2_KDM5A	1163..1215	CDD:277079	22/55 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1327..1348		8/27 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1407..1433		3/25 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1490..1509		6/57 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1516..1543		8/47 (17%)
		PHD3_KDM5A	1608..1659	CDD:277156	27/51 (53%)
		Interaction with LMO2. /evidence=ECO:0000269\|PubMed:9129143	1623..1690		24/39 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151680
Domainoid	1	1.000	221	1.000	Domainoid score	I2615
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3419
Inparanoid	1	1.050	1252	1.000	Inparanoid score	I176
Isobase	1	0.950	-	0	Normalized mean entropy	S2454
OMA	1	1.010	-	-		QHG53001
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	1	1.000	-	-		FOG0000761
OrthoInspector	1	1.000	-	-		otm40656
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R628
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750