DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and jarid2b

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_001189388.1	Gene:	jarid2b / 558456	ZFINID:	ZDB-GENE-060503-246	Length:	1319	Species:	Danio rerio

Alignment Length:	921	Identity:	228/921 - (24%)
Similarity:	369/921 - (40%)	Gaps:	225/921 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TNSGSESVKKSNANDEPSTPVTPAGATGSHTHAPPGISPA-----------------VMERPMPS 99
            |...:..::|:.....||.|..||..:.....|.|  .||                 ..:|...:
Zfish   493 TEMAASPIQKTGPAPPPSPPAAPASPSMPQNPAIP--EPARQRPKRASAGKLMFIRKAQQRAQTN 555

  Fly   100 VPMNHASSSVSASKKYHNSCPHPTPTPAPTGHKKSVHTQPHSSNKFDQGKNEE-------FHFDT 157
            ..:|..:|:.||||.:..:  .||.||.|               :.|:.:..|       ..:..
Zfish   556 PTLNRTTSTTSASKSFKPA--EPTHTPPP---------------RLDRDRERERERERSRARYAA 603

  Fly   158 PPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRLNEL 222
            ..:.|:|:|::.||::||.|:...|...|.||:.::|||..|.|...:: |::|||.:|||:::|
Zfish   604 LGDVPIFKPSSREFQDPLVYLDSFREQVESCGLCRVLPPTDWRPECKLN-DEMRFVTQVQRIHKL 667

  Fly   223 EAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKA-----------------LDLYTLHRIVQEEG 270
            ..:....:..|..|.|..:.||.|:..|.|..|:                 :||.....:|.:.|
Zfish   668 GRRWGPNVQKLACIKKHLKSQGISMDQPPVIGKSFKSSAFRSAFVCIGGCEVDLARFSELVCDLG 732

  Fly   271 GMEQTTKDRKWAKVANRMQYP-SSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPV 334
            ||:|....:||:::|:.::.| |::...|.|:..|.:.|..::      :|.|....
Zfish   733 GMQQVMDLKKWSRLADLLRIPKSAQDRLAKLQEAYLQFLLSYD------LLSPEELQ-------- 783

  Fly   335 KLEDGGGTDYKAHEIPTRQQIAPPNETNTRR----SKRFGNSNASCGLSGVTPTTKPSAGVFVKT 395
            :||               |::....|...|:    .....|.:.|..|    |..:|..|:
Zfish   784 RLE---------------QEVRAEKEALERKRGPLEGHSDNGHHSLAL----PRYEPKNGL---- 825

  Fly   396 ETKEEFKRDLLSSFNAV-NSGGSPLATGTTANTRGASQKKGGEPPALIVDPLMKYICHICNRGDV 459
                    :.||..|.. |....|.........|..:|:|.||          |..|.     :.
Zfish   826 --------NGLSHRNGFRNHHKEPDIQRQAGRRRLFAQEKKGE----------KVECE-----ET 867

  Fly   460 EESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGFEQAEREYTLQQFGQM 524
            ||.| ..:|.....|                   :|:.:              .|..:|..|.::
Zfish   868 EEEM-EDEGVLSDQH-------------------KCIYK--------------GRSVSLTTFYRI 898

  Fly   525 ADQFKQEYFRKPVHLVPTEMVEREFWRIVSSIDEDVTVEYGADLHTMDHGSGFPTKSSLYLLPGD 589
            |......||.|......   ||:::||||...|..|.|.|| .:.|..||||||...|
Zfish   899 ARNTMMMYFNKEPGAAE---VEQDYWRIVEQRDCHVAVHYG-KVDTNTHGSGFPVGKS------- 952

  Fly   590 QEYAESSWNLNNLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEP 654
            :.:::..|||..||....|||.|:.| :.|:..||:.:||.|:..||..:.:....|:|||.|..
Zfish   953 EPFSKHGWNLTVLPNNSGSILRHLGA-VPGVTIPWLNIGMVFSTSCWSQDQNRLPYIDYLHTGAD 1016

  Fly   655 KTWYGVPGSCAEQFEE---TMKQA--APELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAG 714
            ..||.:|.....:.::   |:.||  .|.|     ::|.:.|.| :|.:|....:.|.||.|.:|
Zfish  1017 CIWYSIPAEEKTKLDKVVHTLLQANGTPGL-----EMLEKNVMI-SPEVLCREGIKVHRTVQQSG 1075

  Fly   715 EFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHYSMLRRFCVFSHDELVCKMALEPA 779
            :||:.||.|:.:....||:.:|.|:||...|:.:|.|........|....||.::|:.::|...|
Zfish  1076 QFVVVFPGAFVSRVCCGYSVSETVHFATPQWMNLGYEAAKDLKCRRIAKPFSMEKLLYQIATAEA 1140

  Fly   780 K----LTFGIATACYIDMAEMVDTEKKLRKSLLEWGV-----------------TRAERRAFELV 823
            |    |.....::...|:..:   |.|.|:.|.|.|:                 ||.:.|.:..:
Zfish  1141 KRENRLVLSTISSLLKDLRNI---EMKQRQELYEAGLLSSARYCTHDHNQSPADTRKKPRKWLAL 1202

  Fly   824 NDDERHCQECNTTCFLSAVACECNDKLIVCLR---HYTVLCGCAPEKH------TLIYRYTLDEM 879
            ...||.||.|...|:||.|..| |:.::.||.   ||.       |||      .::|||..:::
Zfish  1203 ESSERRCQMCQHLCYLSMVVQE-NENVVFCLECALHYV-------EKHKNCRGLKMMYRYDEEQI 1259

  Fly   880 PLMLQKLKVKA 890
            ..::.::..||
Zfish  1260 NSLVNQVCGKA 1270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	16/40 (40%)
		ARID	227..312	CDD:198082	25/102 (25%)
		PHD1_Lid_like	450..495	CDD:277078	6/44 (14%)
		JmjC	624..740	CDD:202224	38/120 (32%)
		zf-C5HC2	830..882	CDD:280996	19/60 (32%)
		PLU-1	896..1229	CDD:285609
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
jarid2b	NP_001189388.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..130
		Nuclear localization signal. /evidence=ECO:0000250	96..102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..265
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..382
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..478
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	499..537		10/39 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..599		14/66 (21%)
		JmjN	607..647	CDD:128818	16/39 (41%)
		ARID	673..775	CDD:198082	25/101 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..818		4/23 (17%)
		GSGFP motif	944..948		3/3 (100%)
		JmjC	986..1101	CDD:202224	38/120 (32%)
		zf-C5HC2	1209..1262	CDD:280996	19/60 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020