DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and KDM4D

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_060509.2	Gene:	KDM4D / 55693	HGNCID:	25498	Length:	523	Species:	Homo sapiens

Alignment Length:	428	Identity:	117/428 - (27%)
Similarity:	172/428 - (40%)	Gaps:	120/428 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 SNASCGLSGVTPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKGG 436
            |.|:|       ...|:..:.:...|||||     :.|:
Human     6 SKANC-------AQNPNCNIMIFHPTKEEF-----NDFD-------------------------- 32

  Fly   437 EPPALIVDPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVS 501
                       |||.::.::|.....:                  ...||..||.. |...:.:|
Human    33 -----------KYIAYMESQGAHRAGL------------------AKIIPPKEWKA-RETYDNIS 67

  Fly   502 K-------PQEAFG-------FEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFW-- 550
            :       .|.|.|       :.:.::..|:.::..:|:..|   ::.|.| ...|.:||::|
Human    68 EILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKK---YQTPPH-QNFEDLERKYWKN 128

  Fly   551 RIVSSIDEDVTVEYGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINA 615
            ||.:|      ..||||:    .||.|...:             ..|||.:|..::|.:......
Human   129 RIYNS------PIYGADI----SGSLFDENT-------------KQWNLGHLGTIQDLLEKECGV 170

  Fly   616 DISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELF 680
            .|.|:|.|::|.||....|.||.||...|||||||.|||||||.||....::.|...::..|...
Human   171 VIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSS 235

  Fly   681 SSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADW 745
            ......|...|.:::|.:|..|.:|..|..|.||||::|||..||||||.|:|.|||:|||...|
Human   236 RGCGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRW 300

  Fly   746 L---KMGRECVNHYSMLRRFCVFSHDELVCKMALEPAK 780
            :   ||..:|    |.......||.|..|  ..|:|.:
Human   301 IDYGKMASQC----SCGEARVTFSMDAFV--RILQPER 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818
		ARID	227..312	CDD:198082
		PHD1_Lid_like	450..495	CDD:277078	6/44 (14%)
		JmjC	624..740	CDD:202224	52/115 (45%)
		zf-C5HC2	830..882	CDD:280996
		PLU-1	896..1229	CDD:285609
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
KDM4D	NP_060509.2	JmjN	19..53	CDD:280526	10/93 (11%)
		JmjC	179..295	CDD:202224	52/115 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151683
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840