DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and kdm5c

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_001116706.1	Gene:	kdm5c / 553406	ZFINID:	ZDB-GENE-060810-94	Length:	1578	Species:	Danio rerio

Alignment Length:	1690	Identity:	679/1690 - (40%)
Similarity:	925/1690 - (54%)	Gaps:	314/1690 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 FDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRL 219
            |..|||||||.|:.|||.:||.||:|||.||||.||.||.||..|.|||||:||...|.||:|||
Zfish     8 FVPPPECPVFEPSWEEFADPLGYIAKIRPIAEKSGICKIRPPPDWQPPFAVEVDNFHFTPRIQRL 72

  Fly   220 NELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKV 284
            |||||:||||||:||:||||||:||||||||.:||:.|||::|.:||.||||.|..:|:|:||:|
Zfish    73 NELEAETRVKLNYLDRIAKFWEIQGSSLKIPNLERRILDLFSLAKIVTEEGGFESVSKERRWARV 137

  Fly   285 ANRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVLGP-TPTSSGSGSTPVKLEDGGGTDYKAHE 348
            |.::.||..|::|:.|::|||||::|||::.||..|.| .|....|        |....:||.|.
Zfish   138 AQKLGYPPGKNIGSLLRSHYERIVYPFELFQSGASLPPRKPRQYDS--------DEVDREYKPHS 194

  Fly   349 IPTRQQIAPPNETNT--RRSKRFGN-----------SNASCGLSGVTPTTKP------------- 387
            ||.||.: ||::.::  ||:.|...           :..|..:|...||.:.
Zfish   195 IPLRQSV-PPSKMSSYGRRANRLQPEGPEDPTHHPLTTGSQHISSPEPTEEDIEKNPELKKLQIY 258

  Fly   388 SAGVFV---------KTETKEEFKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALIV 443
            .||..:         ||..|::..:.::...:||..  .|..|..|.:......    .||.||:
Zfish   259 GAGPKMMGLGLVPRDKTRKKDDLPQTVIVRDSAVKD--EPAETAVTKSDPDIPP----PPPNLII 317

  Fly   444 -------------------DPLMK-----------------YICHICNRGDVEESMLLCDGCDDS 472
                               :|..|                 ::|.:|.|||.:|.::|||||||:
Zfish   318 KEDVDDDKSHIDKPNDPSDEPCTKMTMRLRRNLNNPQFVDSFVCRMCGRGDEDEKLMLCDGCDDN 382

  Fly   473 YHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPV 537
            ||||||:||||..|||.|.||:||.||..||.||||||||.||||||.||:|||.||.:||..||
Zfish   383 YHTFCLIPPLTDPPKGNWRCPKCVAEECKKPSEAFGFEQATREYTLQSFGEMADTFKADYFNMPV 447

  Fly   538 HLVPTEMVEREFWRIVSSIDEDVTVEYGADLHTMDHGSGFPTKS-SLYLLPGDQEYAESSWNLNN 601
            |:||||:||:||||:||||:||||||||||:|:.:.|||||..: ...|...::|||.|.||||.
Zfish   448 HMVPTELVEKEFWRLVSSIEEDVTVEYGADIHSKEFGSGFPVNNGKRQLSEEEEEYARSGWNLNV 512

  Fly   602 LPLLEDSILGHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAE 666
            :|:||.|:|.|||||||||..||:||||.|:|||||.|||||||||||||||||||||||.|.||
Zfish   513 MPVLEQSLLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPCSAAE 577

  Fly   667 QFEETMKQAAPELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQG 731
            :.||.||:..||||..||||||||||||||||||::.|||.||:|.|||||||||||||:|||||
Zfish   578 KLEEVMKKLTPELFEFQPDLLHQLVTIMNPNILMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQG 642

  Fly   732 YNFAEAVNFAPADWLKMGRECVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEM 796
            |||||||||..||||..||.|:.||..|||:||||.:||.||||..|.||...:|.|.:.:|..:
Zfish   643 YNFAEAVNFCTADWLPTGRSCIEHYRQLRRYCVFSQEELTCKMAACPEKLDLNLAAATHREMFII 707

  Fly   797 VDTEKKLRKSLLEWGVTRAERRAFELVNDDERHCQECNTTCFLSAVAC-ECNDKLIVCLRHYTVL 860
            |..|:||||||||.|:..|||.||||:.||||.|.:|.|||||||:|| .|.::| |||.|...|
Zfish   708 VQEERKLRKSLLERGIKEAEREAFELLPDDERQCDKCKTTCFLSALACSNCPERL-VCLYHAQDL 771

  Fly   861 CGCAPEKHTLIYRYTLDEMPLMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQELQELCKEAE 925
            |.|..||..|.|||||||:..||.:|||:|.||:.|.:|.::.::......:.:::|:.|.:||.
Zfish   772 CSCPSEKLYLRYRYTLDELLAMLHRLKVRAESFDSWANRVKEALEQDEGNKIDIKDLEVLKEEAA 836

  Fly   926 TKKFPSSLLIDRLNAAAVEAEKCVTVIQQLGINKVRTRSDHNQEAAQYKLTMEELELFVQEIDNL 990
            .||||::.|:.|||...|:.|||.:...:|..|...:|           :|::||:..|..:.||
Zfish   837 DKKFPNNELLQRLNTVFVDIEKCESCSTELLSNSQSSR-----------MTLKELKTLVDTMQNL 890

  Fly   991 CCIIDEGASVRELLVLGKQFVERSESQLQLSLESLEE-----------SELETLINEGSSLRIEL 1044
            .|:|.:...|:.:|    |.:|..:|:.|:.::|.:.           :|::.|:.||:||.:..
Zfish   891 PCVIKQQDEVQLIL----QKIEEFDSRAQVLVDSTKSEWKQDSPLPVATEIQALLEEGASLPVIA 951

  Fly  1045 QQLDLLQKRLKQCKW---YKRSQGLRETSSKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQI 1106
            ...:||...|:|.:|   .:|:.|  ...|::|...::||:. :..:: |....|:..|.:||::
Zfish   952 PACELLSGLLEQGRWLGEVRRTLG--PEGSEVTLTVLRNLME-SGCNV-PQSVSVETAMAELQEL 1012

  Fly  1107 GADIEAWESQAAKYFRRLTQQHELGEIEQFLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQ 1171
            ....|.|| :.|:......|:|.|..:|..:..|..|..|:|:...|:..|.:||.|:..:|::|
Zfish  1013 LTIAERWE-EKAQICLEDRQKHHLSTLEAIVNEAQLIPVQLPNILSLQACLSRARAWVTDLEEIQ 1076

  Fly  1172 QNNHVTYCHTLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMP- 1235
            ...|......||.::..|.::|:::|||.:::..:.|||.|::..:..||||.:.::|||||.|
Zfish  1077 NGEHYPCLDDLEGLVAIGRDLPVKMEELKQLELQVASAHSWREKASKTFLKKNSQHSLLEVLCPC 1141

  Fly  1236 ---------RSDAINIDSD---LKPRFQDDFLKEKNPAEIVASFKHAE--EQELL---------- 1276
                     .|.....|||   |....||    .::|..||.:||..|  |:|.|
Zfish  1142 VEKSKKMEDNSMVTEADSDVNVLGLTAQD----LRDPGAIVMAFKEGERLEKEALLRLQQVNLAK 1202

  Fly  1277 ---------DMRELRRQNMNKNPMR------------------------DMFCLCKSEFRNLMFN 1308
                     |...::.:....|.|.                        ...|:|....|.|:..
Zfish  1203 PSIENGVSTDQDSIKTEKKQSNSMETDVPLNSDSPVLQNGGSSHSLTSSQTVCICGGPPRPLLHR 1267

  Fly  1309 CQLCRDWFHEDCV--PPPSATNQNGIVNGGSGPGTNRP--------KWLCPSCVRSKRPRLETIL 1363
            |.||:||||..||  ||..||:...:         .:|        ::|||.|.||:||||||||
Zfish  1268 CHLCKDWFHGGCVSFPPLLATSDTHL---------TKPLCWWDWNTRFLCPRCQRSRRPRLETIL 1323

  Fly  1364 PLLVQLQQLPIRLPEDEALRCLAERAMNWQDRARKALSSPDVSAAQEAIMAQQQQKRRSEGGAGV 1428
            .|||.||:||:||||.|||:||.|||:|||.||::||.:|:|   |||:...||.:...
Zfish  1324 ALLVALQRLPVRLPEGEALQCLTERAINWQGRAKQALDTPEV---QEALDRLQQVEDEM------ 1379

  Fly  1429 GNIS-SPRKPRRRGSLTKEASGSTESDADDDDDEDECRLRIVEDNFSNDEDEPRTAPATS----- 1487
              :| ...:|..:    |:.:|.......|.::.::..:.:.||..|..::|......|.
Zfish  1380 --VSIKEEEPEEK----KKWNGDAVIVLSDSEEAEDGVIDLTEDGNSPKKNERNAVNGTQSGCEN 1438

  Fly  1488 -----------TVNSDLLKL----------LSDSEIENLLDLMMEGDLLEVSLDETQELWRILE- 1530
                       |....||.|          |:.|....|.:|.:|||||||:||:|..::|||:
Zfish  1439 GIGRKSSAHEVTGVESLLSLVPSLKGPVVELNTSVRAQLEELQLEGDLLEVTLDQTHAIYRILQA 1503

  Fly  1531 -TMPP-----TLLQAEAMERVVQYMQRQRQQHTNPLPTSGAEDSNDSLMVQNSPNSNSNSGGATG 1589
             :.||     ||:|.|        :|.||
Zfish  1504 SSQPPQDTLRTLIQIE--------LQEQR------------------------------------ 1524

  Fly  1590 SASNSGRNKKRRSNDTGGNSAVPRKKQSTPKQTPGKKGSAAAARKSDAKASPAASTTPGADADAE 1654
               :|||..|.:      :|...||.|.|       :|...:...||.|.:.|.:.:|..|...:
Zfish  1525 ---SSGRGNKSK------DSKRKRKSQKT-------EGEPKSTEASDCKKTKALNLSPPTDTHTD 1573

Fly 1655 1654
Zfish 1574 1573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	27/40 (68%)
		ARID	227..312	CDD:198082	51/84 (61%)
		PHD1_Lid_like	450..495	CDD:277078	29/44 (66%)
		JmjC	624..740	CDD:202224	94/115 (82%)
		zf-C5HC2	830..882	CDD:280996	30/52 (58%)
		PLU-1	896..1229	CDD:285609	93/346 (27%)
		PHD2_KDM5A	1295..1351	CDD:277079	21/65 (32%)
		PHD3_KDM5A_like	1755..1805	CDD:277083
kdm5c	NP_001116706.1	JmjN	13..54	CDD:128818	27/40 (68%)
		BRIGHT	80..170	CDD:128777	53/89 (60%)
		PHD1_KDM5C_5D	360..405	CDD:277077	29/44 (66%)
		JmjC	535..651	CDD:202224	94/115 (82%)
		zf-C5HC2	741..793	CDD:280996	30/52 (58%)
		PLU-1	806..1134	CDD:285609	93/347 (27%)
		PHD2_KDM5C_5D	1254..1311	CDD:277081	21/65 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	218	1.000	Domainoid score	I2588
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1116	1.000	Inparanoid score	I218
OMA	1	1.010	-	-		QHG53001
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	1	1.000	-	-		FOG0000761
OrthoInspector	1	1.000	-	-		otm24561
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R628
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870