DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lid and ATP5F1B

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_001677.2	Gene:	ATP5F1B / 506	HGNCID:	830	Length:	529	Species:	Homo sapiens

Alignment Length:	393	Identity:	71/393 - (18%)
Similarity:	120/393 - (30%)	Gaps:	144/393 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   938 LNAAAV---EAEKCVTVIQQLGINKVRTRSDHNQEAAQYKLTMEELELFVQEIDNLCCIIDEGAS 999
            |||..|   |....:.|.|.||.:.|||            :.|:..|..|:...    ::|.||.
Human    83 LNALEVQGRETRLVLEVAQHLGESTVRT------------IAMDGTEGLVRGQK----VLDSGAP 131

  Fly  1000 V----------RELLVLG-----------KQFVERSESQLQLSLESLEESELETLIN-------- 1035
            :          |.:.|:|           |||........:....|:|:..|.|.|.
Human   132 IKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQEILVTGIKVVDLLAPY 196

  Fly  1036 ---------EGSSLRIELQQLDLLQKRLKQCKWYKRSQGLRETSSKLTYQDVKNLLH-------I 1084
                     .|:.:...:..::|:....|....|....|:.|.:     ::..:|.|       |
Human   197 AKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERT-----REGNDLYHEMIESGVI 256

  Fly  1085 AAADLDPTDPYVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHEL---GEIEQFLKSASDIN-- 1144
            ...|.......|..:|.:.....|.:.......|:|||....|..|   ..|.:|.::.|:::
Human   257 NLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSAL 321

  Fly  1145 -GQVPSHGLLKDALRKAREWLRAVEQLQQNNHVTYCHTLEAMIERGLNIPIQLEELSRMQGHLNS 1208
             |::||                         .|.|..||..             ::..||..:.:
Human   322 LGRIPS-------------------------AVGYQPTLAT-------------DMGTMQERITT 348

  Fly  1209 AHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINIDSDLKPRFQDDFLKEKNPAEIVASFKHAEEQ 1273
            .            |||:..::..:.:|..|                |.:..||   .:|.|.:..
Human   349 T------------KKGSITSVQAIYVPADD----------------LTDPAPA---TTFAHLDAT 382

  Fly  1274 ELL 1276
            .:|
Human   383 TVL 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818
		ARID	227..312	CDD:198082
		PHD1_Lid_like	450..495	CDD:277078
		JmjC	624..740	CDD:202224
		zf-C5HC2	830..882	CDD:280996
		PLU-1	896..1229	CDD:285609	63/344 (18%)
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
ATP5F1B	NP_001677.2	PRK09280	58..524	CDD:236447	71/393 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900