DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and kdm5bb

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	XP_005167081.1	Gene:	kdm5bb / 415256	ZFINID:	ZDB-GENE-030424-1	Length:	1522	Species:	Danio rerio

Alignment Length:	1744	Identity:	658/1744 - (37%)
Similarity:	925/1744 - (53%)	Gaps:	317/1744 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 QGKNEEFHFDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLR 211
            ||..|   |..|||||||.|:.||||:|.|:|:|||.||||.||.|:.||..|.||||.|||:|.
Zfish     4 QGPAE---FTPPPECPVFEPSWEEFKDPFAFINKIRPIAEKTGICKVRPPPDWQPPFACDVDRLH 65

  Fly   212 FVPRVQRLNELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTT 276
            |.||:||||||||:|||||||||||||||:|||.:||||.||||.||||.|:::|.:|||.:...
Zfish    66 FTPRIQRLNELEAQTRVKLNFLDQIAKFWDLQGCTLKIPHVERKILDLYQLNKLVADEGGFDLVC 130

  Fly   277 KDRKWAKVANRMQYPSSKSVGATLKAHYERILHPFEVYTSG-KVLGP--TPTSSGSGSTPVK--- 335
            ::|:|.|:|..|.:...|:||:.|:|||||||:|:.::.|| .:|.|  ....:|.|..||.
Zfish   131 RERRWTKIAMTMGFAPGKAVGSHLRAHYERILYPYNLFQSGTNLLAPEFAVKLTGFGEPPVLEEC 195

  Fly   336 LEDGG------GTDYKAHEIPTRQQIAPPNETNT----RRSKRFGNSNASCGLS----GV--TPT 384
            |:..|      ..:||.|::..||.: |...:||    ||:||. .:.:.|..|    ||  .|.
Zfish   196 LQKPGDEVNDIDKEYKPHDLLQRQNV-PLQPSNTSAPARRAKRM-KTESGCIKSEEGEGVENKPN 258

  Fly   385 TKPSAGVF-VKTETKEEFKRDL------LSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALI 442
            .:...|.| ||||.|:|....:      :...|.......|            .:|....||..:
Zfish   259 LRRRMGSFVVKTEQKKEIPIQVKEEPVEIKELNPEPEKSKP------------KKKNIPPPPVSM 311

  Fly   443 VDPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAF 507
            ||   .|:|.:|.:|:.|:.:|||||||||||||||:||||.:|||:|.||:|:.:|..||||||
Zfish   312 VD---LYVCLVCGKGNDEDRLLLCDGCDDSYHTFCLIPPLTDVPKGDWRCPKCLTQECCKPQEAF 373

  Fly   508 GFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVSSIDEDVTVEYGADLHTMD 572
            |||||.|:|||:.||:|||.||.:||..|||:||||:||:||||:|.:|.||||||||||:.:.:
Zfish   374 GFEQAHRDYTLKAFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVGTIQEDVTVEYGADIASKE 438

  Fly   573 HGSGFPTKSSLY-LLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCW 636
            .|||||.|...: :.|.|::|.:..|||||:.::..|:|.|:.|||.||..||:||||||::|||
Zfish   439 FGSGFPIKGGRFKIAPHDEKYLQCGWNLNNMAMMTPSVLTHVTADICGMTLPWLYVGMCFSSFCW 503

  Fly   637 HNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLHQLVTIMNPNILMN 701
            |.|||||||||||||||||||||.||..|||.|..||:.|||||.||||||||||||||||.||.
Zfish   504 HIEDHWSYSINYLHWGEPKTWYGAPGFAAEQLEAVMKKLAPELFDSQPDLLHQLVTIMNPNTLMA 568

  Fly   702 NRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHYSMLRRFCVFS 766
            :.||::||:|.||||||||||:||:|||||:||||||||...||:.:||:||:||..|.|:||||
Zfish   569 HGVPIYRTNQCAGEFVITFPRSYHSGFNQGFNFAEAVNFCTVDWMPLGRQCVDHYRQLHRYCVFS 633

  Fly   767 HDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAERRAFELVNDDERHCQ 831
            |||:||.||::...|...:|:|...||..|:..|::||:.:.:.||.:.|...::|:.||||.|.
Zfish   634 HDEMVCNMAMKADCLDVVLASAVQKDMQLMIKEERELREKVRKMGVAQCELFQYDLLADDERQCV 698

  Fly   832 ECNTTCFLSAVACECNDKLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMPLMLQKLKVKAHSFERW 896
            :|.|||:|||:.|.|...:.|||.|...||.|....:||.||:|||::..|:..::.:|..::.|
Zfish   699 KCRTTCYLSALTCPCRPGVQVCLYHTHDLCSCPISNYTLNYRFTLDDLYPMMNAVRQRAEYYDDW 763

  Fly   897 LSRCRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLIDRLNAAAVEAEKCVTVIQQLGINKVR 961
            .||..::::|.......:...:.|.:|:..:.||.:.|:.:|.....:||||.:|.|||...|.:
Zfish   764 ASRVTEVMEAKLDKKRNVTVFRTLLEESNEQSFPENDLLRQLRLVTQDAEKCSSVAQQLLNGKRQ 828

  Fly   962 TRSDHNQEAAQYKLTMEELELFVQEIDNLCCIIDEGASVRELLVLGKQFVERSESQLQLSLESLE 1026
            ||....:..:..:||:||:..||:::.||.|.:.:...::|||...:.|.:.||..|...:.:..
Zfish   829 TRYRTGKAKSPNQLTVEEMRSFVRQLYNLPCSLTQAPLLKELLNSIEDFQQHSEKLLSDEVSADA 893

  Fly  1027 ESELETLINEGSSLRIELQQLDLLQKRLKQCKWYKRSQGLRETSSK------LTYQDVKNLLHIA 1085
            .||:|:|:.|||...:.|.:|.||::||:|.:|.   .|:.:....      |:.:.::.|:. .
Zfish   894 VSEIESLLEEGSQFDVFLPELPLLRERLEQARWL---TGVHQAEDPVANPCGLSLESMRRLID-R 954

  Fly  1086 AADLDPTDPYVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHELGEIEQFLKSASDINGQVPSH 1150
            ...|.| .|.:::.|.:||::....|..|..|....:....: .|..:...|.....:...:|:.
Zfish   955 GVGLTP-HPSIERMMARLQELLTVSEELEENAQALLKARPPE-SLETLCSMLTQVEGVPAYLPNC 1017

  Fly  1151 GLLKDALRKAREWLRAVEQLQQNNHVTYCHTLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDN 1215
            .||:|.:.:|:|||:..|.||....|....:|..|:.|..:||::||.|.:::..::....||:.
Zfish  1018 LLLQDTVNRAKEWLQEAESLQVGGQVPVFSSLSDMVLRAHSIPVRLEPLDQLEVQVSEVQSWKET 1082

  Fly  1216 TACAFLKKGTFYTLLEVLMPRSDA------------------------INID--SDLKPRFQDDF 1254
            .|..||.|.:.:||||||.||.:.                        :.:|  ||::....|
Zfish  1083 AAKTFLIKSSPFTLLEVLCPRWEMGSSLKKKKMRKMKGDCVSSGKKKFVKLDSMSDVERALSD-- 1145

  Fly  1255 LKEKNPAEIVASFKHAEEQELLDMRELRRQNMNK-NPMRD----MFCLCKSEFRNLMFNCQLCRD 1314
              .|:.|..:.:......:||..:..||..|.:| .|..|    ..|:|:......|..|:||||
Zfish  1146 --SKDSASAMFTLAEVRLKELESLCSLRASNESKLLPTADCASLKVCVCQKPAMGAMLQCELCRD 1208

  Fly  1315 WFHEDCVPPPSATNQNGIVNGGSGPGTNRPKWLCPSCVRSKRPRLETILPLLVQLQQLPIRLPED 1379
            .||..|            |.|.|.| .:...||||.|:||.:|.|:.|..||..||::.:||||.
Zfish  1209 AFHSVC------------VRGPSDP-LDPEAWLCPLCLRSTKPPLDKIRSLLSSLQRIRVRLPEG 1260

  Fly  1380 EALRCLAERAMNWQDRARKALSSPDVSAAQEAIMAQQQQKRRSEGGAGVGNISSPRKP--RRRGS 1442
            :|||.:.||:::||.|.|:.:.|..:|:.             |:.|.|    :||.:.  |..|.
Zfish  1261 DALRYMIERSVSWQRRVREVIDSYGLSST-------------SQDGRG----ASPSQNLYRSTGH 1308

  Fly  1443 LTK-EASGSTESDADDDDDEDECRLRIVEDNFSNDED-----EPRTAPATSTVNSDLLKLLSDSE 1501
            ..| :..||..              |..:...|..|.     |.|..|         |:.|| .|
Zfish  1309 SRKLQLCGSPS--------------RCQDWAVSGQEQTVFYTEQRCIP---------LQGLS-PE 1349

  Fly  1502 IENLLDLMMEGDLLEVSLDETQELWRILETMPPTLLQAEAMERVVQYMQRQRQQHTNPLPTSGAE 1566
            :|   :||:||.:|:|||.|||:|:|:|.:.|||                     ||   ||.||
Zfish  1350 LE---ELMVEGLVLQVSLPETQQLYRLLLSGPPT---------------------TN---TSHAE 1387

  Fly  1567 DSNDSLMVQNSPNSNSNSGGATGSASNSGRNKKRRSNDTGGNSAVPRKKQSTPKQTPGKKGSAAA 1631
                                                          .|...||.||
Zfish  1388 ----------------------------------------------HKSYLTPPQT--------- 1397

  Fly  1632 ARKSDAKASPAASTTPGADADAENKQANGGNTNSSTGSGGGNSATTTPTPGSTHKKRKRTSTTAT 1696
                                          .|::.|               |..||.||
Zfish  1398 ------------------------------ETDAIT---------------SAEKKAKR------ 1411

  Fly  1697 NNNNNNNNNSTNNSNSSTNLNSNTTSGQGAATGGNNATGGQKKHAQR------SQQAAQEDDEEE 1755
                ..|.:..:.....|.|.|..          ....|.:|:..::      |..:..||.||:
Zfish  1412 ----RMNRDEVDIRERGTKLKSKK----------QRMMGVEKRRERKAASVSASDMSQSEDSEED 1462

  Fly  1756 ---CRAENCHKPTGREVDWVQCDGGCNEWFHMYCVGLNRSQIKPDDDYICIRCT 1806
               |.||:|.:|.|.|||||||| .||.||||.|||:: :::..::||:|:.|:
Zfish  1463 MTLCPAESCLQPEGEEVDWVQCD-CCNRWFHMICVGVS-AELAAEEDYMCVSCS 1514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	26/40 (65%)
		ARID	227..312	CDD:198082	51/84 (61%)
		PHD1_Lid_like	450..495	CDD:277078	29/44 (66%)
		JmjC	624..740	CDD:202224	91/115 (79%)
		zf-C5HC2	830..882	CDD:280996	24/51 (47%)
		PLU-1	896..1229	CDD:285609	92/338 (27%)
		PHD2_KDM5A	1295..1351	CDD:277079	19/55 (35%)
		PHD3_KDM5A_like	1755..1805	CDD:277083	26/52 (50%)
kdm5bb	XP_005167081.1	JmjN	14..55	CDD:128818	26/40 (65%)
		BRIGHT	81..171	CDD:128777	51/89 (57%)
		PHD1_KDM5B	316..361	CDD:277076	29/44 (66%)
		JmjC	491..607	CDD:202224	91/115 (79%)
		zf-C5HC2	697..749	CDD:280996	24/51 (47%)
		PLU-1	762..1096	CDD:285609	92/339 (27%)
		PHD2_KDM5B	1189..1232	CDD:277080	19/55 (35%)
		PHD3_KDM5B	1465..1513	CDD:277157	26/49 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586197
Domainoid	1	1.000	218	1.000	Domainoid score	I2588
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1116	1.000	Inparanoid score	I218
OMA	1	1.010	-	-		QHG53001
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	1	1.000	-	-		FOG0000761
OrthoInspector	1	1.000	-	-		otm24561
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R628
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800