Protein Alignment Kdm5 and Jarid2

DIOPT Version :10

• Sequence 1: NP_523486.1
• Gene: Kdm5 / 33837
• FlyBaseID: FBgn0031759
• Length: 1838
• Species: Drosophila melanogaster
• Sequence 2: NP_648324.1
• Gene: Jarid2 / 39103
• FlyBaseID: FBgn0036004
• Length: 2351
• Species: Drosophila melanogaster
• Alignment Length: 942
• Identity: 227/942 - (24%)
• Similarity: 350/942 - (37%)
• Gaps: 220/942 - (23%)

  Fly     2 SAKTEADNTT----AANSGGGGVGSGTSSG--------GGASANGTATPARRLRTRNSTGNGTNS 54
            |..::|:..|    ...:|.||.|.|...|        |....|........|.|:......:..
  Fly  1566 SGDSDAEGATFYIPLQGAGVGGSGDGGIQGVAVKLGREGPDGPNQKVVMQATLVTKAQMDTNSKP 1630

  Fly    55 GSESVKKSN---------ANDEPSTPVTPAGATGSHTHAPPGISPAVMERPMPS--VPMNHASSS 108
            ..||:..:.         :||..||..:......:.|.|..|.:.|    |..|  |.:|..||.
  Fly  1631 LPESLNTNELVKTLLHAASNDAASTTTSLKSLPKASTSAAAGAAAA----PGASSLVRVNSNSSL 1691

  Fly   109 VSASKKYHNSCPHPTPTPAPTGHKKSVHTQPHSSNKFDQGKNEEF-HFDTPP---ECPVFRPTTE 169
            .|.|.|...:.  .|.:.|....||.....|     .....|..| ..|.|.   |.|:||||.:
  Fly  1692 FSGSAKSRTAA--QTSSTAAAVAKKYKDDTP-----IKMANNTAFPRHDDPTQMVEAPIFRPTEK 1749

  Fly   170 EFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRLNELEAKTRVKLNFLD 234
            ||.:|:.:|.:|..||.:.||.||:|||::.|...:. |::||....|.::::..:.......|.
  Fly  1750 EFADPIEFIERITPIAARFGICKIIPPASFKPECRIS-DEMRFTAYNQYVHKMLHRWGPSAKELS 1813

  Fly   235 QIAKFWELQGSSLK-IPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKVANRMQYPSSKSVGA 298
            .|.|:...|...:. .|.:....:||..|:..|||.||:::..:.:|||:||..|..|
  Fly  1814 AIKKYLATQSIVMNHPPWIGGMEVDLPRLYHTVQELGGLKEVIEKKKWARVAEEMCIP------- 1871

  Fly   299 TLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEIPTRQQIAPPNETNT 363
              |...:|:....::|.  |.|.|..|.|.:...  ||.|....|:...|...|:
  Fly  1872 --KLAQDRVTKLDDIYC--KYLLPYDTLSPAERQ--KLFDEVEADWAKREARARR---------- 1920

  Fly   364 RRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTTANTR 428
                                    :|..||.||:....:.||.|.
  Fly  1921 ------------------------NADRFVNTESVSNEEDDLSSD-------------------- 1941

  Fly   429 GASQKKGGEPPALIVDPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCP 493
                                         :.|||....||                      :..
  Fly  1942 -----------------------------EDEESEEEIDG----------------------VSM 1955

  Fly   494 RCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPT-EMVEREFWRIVSSID 557
            .|:|:..|.|              |.||.::|......:|:.   ..|| ..||.||||.|:..|
  Fly  1956 ECIVKGRSMP--------------LSQFYRIARNTMALWFKS---TDPTVNEVEAEFWRHVAVRD 2003

  Fly   558 EDVTVEYGADLHTMDHGSGFPTKSSLYLLPGDQ----EYAESSWNLNNLPLLEDSILGHINADIS 618
            ..|.|..|: :.:...|.|||:       ||.:    .||...|||..|.....|:|..: ..:.
  Fly  2004 SHVCVHSGS-IDSSGWGYGFPS-------PGPKGKGSNYARHPWNLKVLTNNSGSVLRSL-GPVM 2059

  Fly   619 GMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQ 683
            |:..|.::|||.|:|.||:.:.|....|.|||.|..|.|||:|...:..|...:....|....::
  Fly  2060 GVTVPTLHVGMLFSACCWYRDPHGLSWIEYLHTGASKLWYGIPDDQSANFRAALTSLIPTHCQNK 2124

  Fly   684 PDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKM 748
            ...|.....::.|::|.:..|.:.|.:|..|||::.|||||.:....||..:|:|.||...||.:
  Fly  2125 TIWLPCDTVMVPPHMLTDRGVSLCRIEQKPGEFIVVFPRAYTSSLATGYVVSESVYFATMSWLDL 2189

  Fly   749 GRECVNHYSMLRRFC---VFSHDELVCKMALEPAKLTFGIATACYIDMAEMV----DTEKKLRKS 806
            .::   .:..:...|   :||.::|:..:..:..     :.:.....|..|:    :.|...|:.
  Fly  2190 AKD---DFRDIHESCEPAMFSLEQLLFALGYDQR-----VNSEALHQMLPMLNDVCEKESAAREQ 2246

  Fly   807 LLEWGVTRAERRAFEL-----------VNDDERHCQECNTTCFLSAVACECNDKLIVCLRH--YT 858
            |...|||..|:...|.           ....|..|..|....::|.|..|  |..|.||:|  ..
  Fly  2247 LRAAGVTSTEKVQAEKGQKAKKQQQPPYKSIESECDLCRANLYISMVRTE--DGNIYCLQHALKN 2309

  Fly   859 VLCGCAPEKH-TLIYRYTLDEMPLMLQKLKVK 889
            :..|....|. .|||.|.:|::..::::|:.|
  Fly  2310 LNNGNIQAKQCKLIYAYNVDDIQQLIRQLQEK 2341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm5	NP_523486.1	JmjN	160..201	CDD:128818	20/40 (50%)
		ARID_JARID	226..312	CDD:350628	22/86 (26%)
		PHD1_Lid_like	450..495	CDD:277078	5/44 (11%)
		JmjC	624..740	CDD:396791	38/115 (33%)
		zf-C5HC2	830..882	CDD:460750	17/54 (31%)
		PLU-1	896..1231	CDD:462475
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
Jarid2	NP_648324.1	PHA03247	<157..429	CDD:223021
		Atrophin-1	762..>986	CDD:460830
		JmjN	1740..1781	CDD:128818	20/40 (50%)
		ARID_JARD2	1804..1915	CDD:350634	32/123 (26%)
		cupin_RmlC-like	2066..2181	CDD:477354	38/114 (33%)
		zf-C5HC2	2281..2334	CDD:460750	17/54 (31%)