Protein Alignment Kdm5 and JARID2

DIOPT Version :10

• Sequence 1: NP_523486.1
• Gene: Kdm5 / 33837
• FlyBaseID: FBgn0031759
• Length: 1838
• Species: Drosophila melanogaster
• Sequence 2: XP_011512881.1
• Gene: JARID2 / 3720
• HGNCID: 6196
• Length: 1309
• Species: Homo sapiens
• Alignment Length: 981
• Identity: 243/981 - (24%)
• Similarity: 406/981 - (41%)
• Gaps: 224/981 - (22%)

  Fly     1 MSAKTEADNTTAAN---SGGGGVGSGTSSGGGASANGTATP--------ARRLRTRNSTGNGTNS 54
            :|.|||:.|.....   |.||...|...:..|...:|...|        .|:||.......|..:
Human   438 ISGKTESSNAKTRKQVLSLGGASKSTGPAVNGLKVSGRLNPKSCTKEVGGRQLREGLQLREGLRN 502

  Fly    55 GSESVKKSNANDEPSTP-------VTPAGATGSHTHAPPGISPAVMERPMP------SVPMNHAS 106
            ....:::::..::|.:|       ..||...|....|..|:....:::.:|      :.|....:
Human   503 SKRRLEEAHQAEKPQSPPKKMKGAAGPAEGPGKKAPAERGLLNGHVKKEVPERSLERNRPKRATA 567

  Fly   107 SSVSASKKYHNSCPHPTPTPAPTGHKKSVHTQPHSSNKFDQGKNEEFHFDTPPECPVFRPTTEEF 171
            ...:..::.|......:.....|...:||| :|..|.|.::|..:. .:....|.||.||:.:||
Human   568 GKSTPGRQAHGKADSASCENRSTSQPESVH-KPQDSGKAEKGGGKA-GWAAMDEIPVLRPSAKEF 630

  Fly   172 KNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRLNELEAKTRVKLNFLDQI 236
            .:||.||..:|:..||.|:.:::||..|.|...:: |::|||.::|.:::|..:....:..|..|
Human   631 HDPLIYIESVRAQVEKFGMCRVIPPPDWRPECKLN-DEMRFVTQIQHIHKLGRRWGPNVQRLACI 694

  Fly   237 AKFWELQGSSL-KIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKVANRMQYP-SSKSVGAT 299
            .|..:.||.:: ::|::....|||....|::.|.|||:|.|..:||.|:|:.::.| :::...|.
Human   695 KKHLKSQGITMDELPLIGGCELDLACFFRLINEMGGMQQVTDLKKWNKLADMLRIPRTAQDRLAK 759

  Fly   300 LKAHYERILHPF-------------EVYTSGKVL----GPTPTSSGSGSTPVKLEDGGGTD---Y 344
            |:..|.:.|..:             ||....::|    ||             ||  |.|:   :
Human   760 LQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGP-------------LE--GHTENDHH 809

  Fly   345 KAHEIPTRQQIAPPNETNTRRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEFKRDLLSSF 409
            |.|.:|                 ||...|..  :.||.|...      .:::.||
Human   810 KFHPLP-----------------RFEPKNGL--IHGVAPRNG------FRSKLKE---------- 839

  Fly   410 NAVNSGGSPLATGTTANTRGASQKKGGEPPALIVDPLMKYICHICNRGDVEESMLLCDGCDDSYH 474
                .|.:.|.||   ..|..:|:|                 .:....:.::.:|      :.:|
Human   840 ----VGQAQLKTG---RRRLFAQEK-----------------EVVKEEEEDKGVL------NDFH 874

  Fly   475 TFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHL 539
                               :|:.:              .|..:|..|.:.|.......|.|  ..
Human   875 -------------------KCIYK--------------GRSVSLTTFYRTARNIMSMCFSK--EP 904

  Fly   540 VPTEMVEREFWRIVSSIDEDVTVEYGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNLNNLPL 604
            .|.| :|:|:||:|...|..|.|..| .:.|..||||||...|       :.::...|||..||.
Human   905 APAE-IEQEYWRLVEEKDCHVAVHCG-KVDTNTHGSGFPVGKS-------EPFSRHGWNLTVLPN 960

  Fly   605 LEDSILGHINADISGMNAPWMYVGMCFAAFCW-HNEDHWSYSINYLHWGEPKTWYGVPGSCAEQF 668
            ...|||.|:.| :.|:..||:.:||.|:..|| .:::|..| |:|||.|....||.:|.....:.
Human   961 NTGSILRHLGA-VPGVTIPWLNIGMVFSTSCWSRDQNHLPY-IDYLHTGADCIWYCIPAEEENKL 1023

  Fly   669 EE---TMKQAAPELFSSQPDLLHQLV---TIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAG 727
            |:   |:.||     :..|.|  |::   .:::|.:|....:.|.||.|.:|:||:.||.::.:.
Human  1024 EDVVHTLLQA-----NGTPGL--QMLESNVMISPEVLCKEGIKVHRTVQQSGQFVVCFPGSFVSK 1081

  Fly   728 FNQGYNFAEAVNFAPADWLKMGRECVNHYSMLRRFCV--FSHDELVCKMALEPAKLTFG--IATA 788
            ...||:.:|.|:||...|..||.|...  .|.||...  ||.::|:.::|...||...|  ::|.
Human  1082 VCCGYSVSETVHFATTQWTSMGFETAK--EMKRRHIAKPFSMEKLLYQIAQAEAKKENGPTLSTI 1144

  Fly   789 CYIDMAEMVDTEKKLRKSLLEWGVTRAER-----------------RAFELVNDDERHCQECNTT 836
            ..: :.|:.|||.:.|:.|.|.|:..:.|                 |.:..:...||.||.|...
Human  1145 SAL-LDELRDTELRQRRQLFEAGLHSSARYGSHDGSSTVADGKKKPRKWLQLETSERRCQICQHL 1208

  Fly   837 CFLSAVACECNDKLIVC----LRHYTVLCGCAPEKHTLIYRYTLDEMPLMLQ----KLKVKAHSF 893
            |:||.|..| |:.::.|    |||......|...|  |:|||..:::..::.    |:..|..|.
Human  1209 CYLSMVVQE-NENVVFCLECALRHVEKQKSCRGLK--LMYRYDEEQIISLVNQICGKVSGKNGSI 1270

  Fly   894 ERWLSR 899
            |..||:
Human  1271 ENCLSK 1276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm5	NP_523486.1	JmjN	160..201	CDD:128818	18/40 (45%)
		ARID_JARID	226..312	CDD:350628	25/100 (25%)
		PHD1_Lid_like	450..495	CDD:277078	2/44 (5%)
		JmjC	624..740	CDD:396791	38/122 (31%)
		zf-C5HC2	830..882	CDD:460750	19/55 (35%)
		PLU-1	896..1231	CDD:462475	2/4 (50%)
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
JARID2	XP_011512881.1	JmjN	619..660	CDD:128818	18/40 (45%)
		ARID_JARD2	683..794	CDD:350634	27/110 (25%)
		JmjC	979..1094	CDD:396791	38/122 (31%)
		zf-C5HC2	1202..1255	CDD:460750	19/55 (35%)