DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and Kdm5c

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	XP_038956408.1	Gene:	Kdm5c / 317432	RGDID:	1560601	Length:	1554	Species:	Rattus norvegicus

Alignment Length:	1670	Identity:	688/1670 - (41%)
Similarity:	943/1670 - (56%)	Gaps:	273/1670 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 FDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRL 219
            |..|||||||.|:..||::||.||:|||.||||.||.||.|||.|.|||||:||..||.||:|||
  Rat     8 FLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRL 72

  Fly   220 NELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKV 284
            |||||:||||||:|||||||||:||||||||.|||:.||||:|.:||.||||.|...|||:||:|
  Rat    73 NELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYETICKDRRWARV 137

  Fly   285 ANRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEI 349
            |.|:.||..|::|:.|::|||||::|:|:|.||..|....|.........|       :||.|.|
  Rat   138 AQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRPFDNEEKDK-------EYKPHSI 195

  Fly   350 PTRQQIAPPNETNT--RRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEF-KRDLLSSFNA 411
            |.||.: .|::.|:  ||:||            :.|..:|         |:|:. |...|.....
  Rat   196 PLRQSV-QPSKFNSYGRRAKR------------LQPDPEP---------TEEDIEKNPELKKLQI 238

  Fly   412 VNSGGSPLATGTTANTRG--ASQKKGGE-PPALIV-----------------------------D 444
            ..:|...:..|..|..:.  ...|:|.| ||.::|                             :
  Rat   239 YGAGPKMMGLGLMAKDKNLRKKDKEGPECPPTVVVKEELGGDVKMESASPKTFLEGKEELSHSPE 303

  Fly   445 PLMK-----------------YICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLC 492
            |..|                 |:|.:|:|||.::.:||||||||:||.|||||||..||||.|.|
  Rat   304 PCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRC 368

  Fly   493 PRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVSSID 557
            |:||:.|..:|.||||||||.||||||.||:|||.||.:||..|||:||||:||:||||:|:||:
  Rat   369 PKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIE 433

  Fly   558 EDVTVEYGADLHTMDHGSGFP-TKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMN 621
            ||||||||||:|:.:.||||| :.|..:|.|.::|||.|.||||.:|:||.|:|.|||||||||.
  Rat   434 EDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMK 498

  Fly   622 APWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDL 686
            .||:||||.|:|||||.|||||||||||||||||||||||...||..||.||:..||||.|||||
  Rat   499 VPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDL 563

  Fly   687 LHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRE 751
            ||||||:||||.||::.|||.||:|.|||||||||||||:||||||||||||||..||||..||:
  Rat   564 LHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQ 628

  Fly   752 CVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAE 816
            |:.||..|||:|||||:||:||||..|.||...:|.|.:.:|..||..|::|||:|||.|:|.||
  Rat   629 CIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITEAE 693

  Fly   817 RRAFELVNDDERHCQECNTTCFLSAVAC-ECNDKLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMP 880
            |.||||:.||||.|.:|.|||||||:|| :|.|.| |||.|...||.|:..:..|.|||||||:|
  Rat   694 REAFELLPDDERQCIKCKTTCFLSALACYDCPDGL-VCLSHINDLCKCSSSRQYLRYRYTLDELP 757

  Fly   881 LMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLIDRLNAAAVEA 945
            .||.||||:|.||:.|.::.|..::.......:|:||:.|..||..::||:|.|:.||.....||
  Rat   758 AMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQRLKNCLSEA 822

  Fly   946 EKCVTVIQQLGINKVRTRSDHNQEA-----AQYKLTMEELELFVQEIDNLCCIIDEGASVRELLV 1005
            |.||:  :.||:..       .|||     |..::|:.||:.|:.:::||.|.:.:...|:.:|
  Rat   823 EACVS--RALGLVS-------GQEAGPDRVAGVQMTLAELQDFLGQMNNLPCAMHQIGDVKGIL- 877

  Fly  1006 LGKQFVERSESQLQLSLESLEESE--LETLINEGSSLRIELQQLDLLQKRLKQCKW---YKRSQG 1065
               :.||..:::.:.:|.|...|.  |::|:..|..|.:|:.:...||::::|.:|   .||:
  Rat   878 ---EQVEAYQTEAREALVSQPSSPGLLQSLLERGQQLGVEVPEAQQLQRQVEQARWLDEVKRT-- 937

  Fly  1066 LRETSSKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHEL 1130
            |..::.:.|...::.|| :|.|.:.|: |.|||...:||::....|.|| :.|.......|:|..
  Rat   938 LAPSARRGTLAIMRGLL-VAGASVAPS-PAVDKAQAELQELLTIAERWE-EKAHLCLEARQKHPP 999

  Fly  1131 GEIEQFLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQNNHVTYCHTLEAMIERGLNIPIQ 1195
            ..:|..:..|.:|...:|:...||:||.|||.|:..|:::|..:|......||.::..|.::|:.
  Rat  1000 ATLEAIIHEAENIPVHLPNIQSLKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVG 1064

  Fly  1196 LEELSRMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINIDSDLKPRFQDDFLKE--- 1257
            ||||.:::..:.:||.|::..:..||||.:.|||||||.|.:|| ..||..:.|:.:   ||
  Rat  1065 LEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADA-GSDSTKRSRWME---KELGL 1125

  Fly  1258 ---------------KNPAEIVASFKHAEEQELLDMRELRRQNMNK-NPMRDM--------FCLC 1298
                           ::|..::.:||..|::|...:.:|||.|..| :|:..:        .|:|
  Rat  1126 YKSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLASLTTNSSTASICVC 1190

  Fly  1299 KSEFRNL-MFNCQLCRDWFHEDCVPPPSATNQNGIVNGGSGPGTNRP---------KWLCPSCVR 1353
            ......: ...|.||:||||..||..|.      :::......|:.|         |:|||.|:|
  Rat  1191 GQVPAGVGALQCDLCQDWFHGRCVTVPR------LLSSQRSSLTSSPLLAWWEWDTKFLCPLCMR 1249

  Fly  1354 SKRPRLETILPLLVQLQQLPIRLPEDEALRCLAERAMNWQDRARKALSSPDVSA-------AQEA 1411
            |:||||||||.|||.||:||:||||.|||:||.|||::||.|||:.|:|.:|:|       .::.
  Rat  1250 SRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQVLASEEVTALLGRLAELRQR 1314

  Fly  1412 IMAQQQQKR----RSEGGAGVGNISSPRKPRRRG------SLTKEASGSTESDADDDDDEDECRL 1466
            :.|:.:.:.    .|:||.|.||:     |:.:|      |:|.....:||..:...|.|
  Rat  1315 LQAESKPEESLAYSSDGGDGTGNM-----PKVQGLLENGDSVTSPEKVATEEGSGKRDLE----- 1369

  Fly  1467 RIVEDNFSNDEDEPRTAPATSTVNSDLLKLLSDSEIE-------NLLDLMMEGDLLEVSLDETQE 1524
                                  :.|.||..|:...:|       .|.:||||||||||:|||...
  Rat  1370 ----------------------LLSSLLPQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHS 1412

  Fly  1525 LWRILET-MPP------TLLQAEAMERVVQYMQRQRQQHTNPLPTSGAEDSNDSLMVQNSPNSNS 1582
            :|::|:. .||      |||:.|..||                                  :.:.
  Rat  1413 IWQLLQAGQPPDLKRVQTLLELEKAER----------------------------------HGSR 1443

  Fly  1583 NSGGATGSASNSGRNKKRRSNDTGGNSAVPRKKQSTPKQTPGKKGSAAAARKSDAKASPAASTTP 1647
            ..|.|.       ..::||..|.||....|.:::..||:.......|...::.:..........|
  Rat  1444 TRGRAL-------ERRRRRKVDRGGEPDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEVP 1501

  Fly  1648 GADADAENKQANGGNTNSSTGSGG----GNSATTTPTPGSTHKKR 1688
            ....      .|.|:.::.....|    .::.:.|..|.||...|
  Rat  1502 PVPF------PNNGSPSTQEDQDGLEPVLDAGSDTSAPFSTLTSR 1540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	27/40 (68%)
		ARID	227..312	CDD:198082	56/84 (67%)
		PHD1_Lid_like	450..495	CDD:277078	29/44 (66%)
		JmjC	624..740	CDD:202224	92/115 (80%)
		zf-C5HC2	830..882	CDD:280996	30/52 (58%)
		PLU-1	896..1229	CDD:285609	100/342 (29%)
		PHD2_KDM5A	1295..1351	CDD:277079	18/65 (28%)
		PHD3_KDM5A_like	1755..1805	CDD:277083
Kdm5c	XP_038956408.1	JmjN	13..54	CDD:128818	27/40 (68%)
		ARID_KDM5C_5D	79..170	CDD:350639	59/90 (66%)
		PHD1_KDM5C_5D	326..371	CDD:277077	29/44 (66%)
		JmjC	501..617	CDD:396791	92/115 (80%)
		zf-C5HC2	707..759	CDD:397190	30/52 (58%)
		PLU-1	772..1098	CDD:400641	100/343 (29%)
		PHD_SF	1187..1247	CDD:419867	18/65 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2516
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53001
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	1	1.000	-	-		FOG0000761
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.930