Protein Alignment Kdm5 and Kdm4a

DIOPT Version :10

• Sequence 1: NP_523486.1
• Gene: Kdm5 / 33837
• FlyBaseID: FBgn0031759
• Length: 1838
• Species: Drosophila melanogaster
• Sequence 2: NP_001423737.1
• Gene: Kdm4a / 313539
• RGDID: 1306378
• Length: 1062
• Species: Rattus norvegicus
• Alignment Length: 1257
• Identity: 247/1257 - (19%)
• Similarity: 420/1257 - (33%)
• Gaps: 399/1257 - (31%)

  Fly   378 LSGVTPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALI 442
            ::..:.|..|||.:.....|.|||:.
  Rat     1 MASESETLNPSARIMTFYPTMEEFRN--------------------------------------- 26

  Fly   443 VDPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSK----- 502
               ..:||.:|.::|.....:                  ...:|..||. ||...:::..
  Rat    27 ---FSRYIAYIESQGAHRAGL------------------AKVVPPKEWK-PRTSYDDIDDLVIPA 69

  Fly   503 --PQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPT----EMVEREFWRIVSSIDEDVT 561
              .|...|......:|.:|:......:|: :......:..|.    |.:||::|:       ::|
  Rat    70 PIQQLVTGQSGLFTQYNIQKKAMTVREFR-KIANSDKYCTPRYSEFEELERKYWK-------NLT 126

  Fly   562 VE---YGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMNAP 623
            ..   ||||::           .:||      |.....||:..|..:.|.:.......|.|:|.|
  Rat   127 FNPPIYGADVN-----------GTLY------EQHVDEWNIGRLKTILDLVEKESGITIEGVNTP 174

  Fly   624 WMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLH 688
            ::|.||...:|.||.||...|||||||:||||:||.||....::.|...|...|....|....|.
  Rat   175 YLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLR 239

  Fly   689 QLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRE-- 751
            ..:|:::|.:|....:|..:..|.||||:||||..||||||.|:|.||:.|||...|::.|::
  Rat   240 HKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAV 304

  Fly   752 -CVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVT-R 814
             |.....|::    .|.|..|.:...|..||......:..||  ..:.| .:..:.|.:.|:| |
  Rat   305 LCSCRKDMVK----ISMDVFVRRFQPERYKLWKAGKDSTVID--HTLPT-PEAAEFLKDSGLTPR 362

  Fly   815 AERRAFELVNDDERHCQECNTTCFLSAVACECNDKLIVCLRHYTVL--------CGCAPEKHTLI 871
            |...  |...:|....::........::|    ...|...||...|        ....|::....
  Rat   363 AGNE--ECPEEDSEAAEQGEEGDVKRSLA----KHRIGTKRHRVCLEIPQEVSQSELFPKEELSS 421

  Fly   872 YRYTLDEMPLMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQELQEL-CKEAETKKFPSSLLI 935
            .:|.:.|....|..:: ..||..|.:.......|...||.|..:||:.: .:|.:..:.|.:..:
  Rat   422 GQYEMTECQATLAPVR-PTHSSVRQVEDSLPFPDYSDPTEVKFEELKNVKLEEEDEDEEPEAAAL 485

  Fly   936 D-RLNAAAVEAEKCVTVIQQLGINKVRTRSDHNQEAAQYKLTMEELELFVQEIDNLCCIIDEGAS 999
            | .:|..:||.....:..::...:.:.:.|..:..::..:.|           :::.|   :|
  Rat   486 DLSVNPESVEGRLVFSGSKKKASSSLGSSSSQDSVSSDSETT-----------ESVSC---QG-- 534

  Fly  1000 VRELLVL--------------GKQFVERSESQLQLSLESLEESELETLINEGSSLRIELQQLDLL 1050
             :|..||              |:..|:|..|    :..|:.|.||..:.:|   ..:.|::
  Rat   535 -QEKTVLTVHSYSRGDGKAAPGEPSVKRQRS----APRSISEQELAEVADE---YMLSLEE---- 587

  Fly  1051 QKRLKQCKWYKRSQGLRETSSKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQIGADIEAWES 1115
                     .|:::|.|:..|||...                .|.|      ||:.|:|.|..|
  Rat   588 ---------NKKTKGRRQPLSKLPRH----------------HPLV------LQECGSDDETSE- 620

  Fly  1116 QAAKYFRRLTQQHELGEIEQFLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQNNHVTYCH 1180
                   :||.:.|..|.|                           .|.:.:.||.||....:
  Rat   621 -------QLTPEEEAEETE---------------------------AWAKPLSQLWQNRPPNF-- 649

  Fly  1181 TLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINIDSD 1245
              ||  |:..|     |.:::...|            ||            |.|
  Rat   650 --EA--EKEFN-----ELMAQQAPH------------CA------------VCM----------- 670

  Fly  1246 LKPRFQDDFLKEKNPAEIVASFKHAE----EQELLDMRELRRQNMNKNPMRDMFCL----CKSEF 1302
                             |..::...|    .|...:..|...|.....|:....|.    |.::.
  Rat   671 -----------------IFQTYHQVEFGGFSQSCGNASEPAAQPQRTKPLIPEMCFTTTGCSTDI 718

  Fly  1303 R-----------NLMFNCQLCRDWFHEDC--VPPPSATNQ--------NGI--------VNGGSG 1338
            .           :::.:|:.|....|..|  |||..|:.:        |.:        :.||:.
  Rat   719 NLSTPYLEEDGTSMLVSCKKCSVRVHASCYGVPPAKASEEWMCSRCSANALEEDCCLCSLRGGAL 783

  Fly  1339 PGTNRPKWLCPSC-----------VRSKRPRLETILPLLVQLQQLPIRLPEDEALRCLAERAMN- 1391
            ...|..:|:..||           :..:.|         |.:.::|:...:.:.:.|...|..|
  Rat   784 QRANDDRWVHVSCAVAILEARFVNIAERSP---------VDVSKIPLPRFKLKCVFCKKRRKRNA 839

  Fly  1392 ---WQDRARKALSSPDVSAAQEA-IMAQQQQ----------KRRSEGGAGVGNISSPRKPRRRGS 1442
               .|....:..::..||.||.| :|.|...          :.:           .|...|.:|:
  Rat   840 GCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHK-----------IPNLERAKGA 893

  Fly  1443 LTKEASGSTESDADDDDDEDECRL------RIVEDNFSNDEDEPRTAPATSTVNSDLLKLLSDSE 1501
            |....:|........:....:|.:      ...|.||.:........| ...|:.|.|:|...:
  Rat   894 LLSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYP-EDIVSQDCLQLGPPA- 956

  Fly  1502 IENLLDLMMEGDLLEVSLDETQ 1523
                     ||::::|...:.|
  Rat   957 ---------EGEVVQVRWTDGQ 969

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm5	NP_523486.1	JmjN	160..201	CDD:128818
		ARID_JARID	226..312	CDD:350628
		PHD1_Lid_like	450..495	CDD:277078	7/44 (16%)
		JmjC	624..740	CDD:396791	51/115 (44%)
		zf-C5HC2	830..882	CDD:460750	8/59 (14%)
		PLU-1	896..1231	CDD:462475	61/350 (17%)
		PHD2_KDM5A	1295..1351	CDD:277079	15/88 (17%)
		PHD3_KDM5A_like	1755..1805	CDD:277083
Kdm4a	NP_001423737.1	JmjN	13..55	CDD:128818	11/102 (11%)
		JmjC	175..291	CDD:396791	51/115 (44%)
		PHD_JMJD2A	665..764	CDD:277050	21/150 (14%)
		ePHD_JMJD2A	773..882	CDD:277183	20/117 (17%)
		Tudor_JMJD2A_rpt1	897..951	CDD:410534	8/54 (15%)
		Tudor_JMJD2A_rpt2	954..1009	CDD:410537	4/26 (15%)