DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and Kdm4a

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	XP_006238730.2	Gene:	Kdm4a / 313539	RGDID:	1306378	Length:	1062	Species:	Rattus norvegicus

Alignment Length:	1257	Identity:	247/1257 - (19%)
Similarity:	420/1257 - (33%)	Gaps:	399/1257 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 LSGVTPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALI 442
            ::..:.|..|||.:.....|.|||:.
  Rat     1 MASESETLNPSARIMTFYPTMEEFRN--------------------------------------- 26

  Fly   443 VDPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSK----- 502
               ..:||.:|.::|.....:                  ...:|..||. ||...:::..
  Rat    27 ---FSRYIAYIESQGAHRAGL------------------AKVVPPKEWK-PRTSYDDIDDLVIPA 69

  Fly   503 --PQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPT----EMVEREFWRIVSSIDEDVT 561
              .|...|......:|.:|:......:|: :......:..|.    |.:||::|:       ::|
  Rat    70 PIQQLVTGQSGLFTQYNIQKKAMTVREFR-KIANSDKYCTPRYSEFEELERKYWK-------NLT 126

  Fly   562 VE---YGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMNAP 623
            ..   ||||::           .:||      |.....||:..|..:.|.:.......|.|:|.|
  Rat   127 FNPPIYGADVN-----------GTLY------EQHVDEWNIGRLKTILDLVEKESGITIEGVNTP 174

  Fly   624 WMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLH 688
            ::|.||...:|.||.||...|||||||:||||:||.||....::.|...|...|....|....|.
  Rat   175 YLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLR 239

  Fly   689 QLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRE-- 751
            ..:|:::|.:|....:|..:..|.||||:||||..||||||.|:|.||:.|||...|::.|::
  Rat   240 HKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAV 304

  Fly   752 -CVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVT-R 814
             |.....|::    .|.|..|.:...|..||......:..||  ..:.| .:..:.|.:.|:| |
  Rat   305 LCSCRKDMVK----ISMDVFVRRFQPERYKLWKAGKDSTVID--HTLPT-PEAAEFLKDSGLTPR 362

  Fly   815 AERRAFELVNDDERHCQECNTTCFLSAVACECNDKLIVCLRHYTVL--------CGCAPEKHTLI 871
            |...  |...:|....::........::|    ...|...||...|        ....|::....
  Rat   363 AGNE--ECPEEDSEAAEQGEEGDVKRSLA----KHRIGTKRHRVCLEIPQEVSQSELFPKEELSS 421

  Fly   872 YRYTLDEMPLMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQELQEL-CKEAETKKFPSSLLI 935
            .:|.:.|....|..:: ..||..|.:.......|...||.|..:||:.: .:|.:..:.|.:..:
  Rat   422 GQYEMTECQATLAPVR-PTHSSVRQVEDSLPFPDYSDPTEVKFEELKNVKLEEEDEDEEPEAAAL 485

  Fly   936 D-RLNAAAVEAEKCVTVIQQLGINKVRTRSDHNQEAAQYKLTMEELELFVQEIDNLCCIIDEGAS 999
            | .:|..:||.....:..::...:.:.:.|..:..::..:.|           :::.|   :|
  Rat   486 DLSVNPESVEGRLVFSGSKKKASSSLGSSSSQDSVSSDSETT-----------ESVSC---QG-- 534

  Fly  1000 VRELLVL--------------GKQFVERSESQLQLSLESLEESELETLINEGSSLRIELQQLDLL 1050
             :|..||              |:..|:|..|    :..|:.|.||..:.:|   ..:.|::
  Rat   535 -QEKTVLTVHSYSRGDGKAAPGEPSVKRQRS----APRSISEQELAEVADE---YMLSLEE---- 587

  Fly  1051 QKRLKQCKWYKRSQGLRETSSKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQIGADIEAWES 1115
                     .|:::|.|:..|||...                .|.|      ||:.|:|.|..|
  Rat   588 ---------NKKTKGRRQPLSKLPRH----------------HPLV------LQECGSDDETSE- 620

  Fly  1116 QAAKYFRRLTQQHELGEIEQFLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQNNHVTYCH 1180
                   :||.:.|..|.|                           .|.:.:.||.||....:
  Rat   621 -------QLTPEEEAEETE---------------------------AWAKPLSQLWQNRPPNF-- 649

  Fly  1181 TLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINIDSD 1245
              ||  |:..|     |.:::...|            ||            |.|
  Rat   650 --EA--EKEFN-----ELMAQQAPH------------CA------------VCM----------- 670

  Fly  1246 LKPRFQDDFLKEKNPAEIVASFKHAE----EQELLDMRELRRQNMNKNPMRDMFCL----CKSEF 1302
                             |..::...|    .|...:..|...|.....|:....|.    |.::.
  Rat   671 -----------------IFQTYHQVEFGGFSQSCGNASEPAAQPQRTKPLIPEMCFTTTGCSTDI 718

  Fly  1303 R-----------NLMFNCQLCRDWFHEDC--VPPPSATNQ--------NGI--------VNGGSG 1338
            .           :::.:|:.|....|..|  |||..|:.:        |.:        :.||:.
  Rat   719 NLSTPYLEEDGTSMLVSCKKCSVRVHASCYGVPPAKASEEWMCSRCSANALEEDCCLCSLRGGAL 783

  Fly  1339 PGTNRPKWLCPSC-----------VRSKRPRLETILPLLVQLQQLPIRLPEDEALRCLAERAMN- 1391
            ...|..:|:..||           :..:.|         |.:.::|:...:.:.:.|...|..|
  Rat   784 QRANDDRWVHVSCAVAILEARFVNIAERSP---------VDVSKIPLPRFKLKCVFCKKRRKRNA 839

  Fly  1392 ---WQDRARKALSSPDVSAAQEA-IMAQQQQ----------KRRSEGGAGVGNISSPRKPRRRGS 1442
               .|....:..::..||.||.| :|.|...          :.:           .|...|.:|:
  Rat   840 GCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHK-----------IPNLERAKGA 893

  Fly  1443 LTKEASGSTESDADDDDDEDECRL------RIVEDNFSNDEDEPRTAPATSTVNSDLLKLLSDSE 1501
            |....:|........:....:|.:      ...|.||.:........| ...|:.|.|:|...:
  Rat   894 LLSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYP-EDIVSQDCLQLGPPA- 956

  Fly  1502 IENLLDLMMEGDLLEVSLDETQ 1523
                     ||::::|...:.|
  Rat   957 ---------EGEVVQVRWTDGQ 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818
		ARID	227..312	CDD:198082
		PHD1_Lid_like	450..495	CDD:277078	7/44 (16%)
		JmjC	624..740	CDD:202224	51/115 (44%)
		zf-C5HC2	830..882	CDD:280996	8/59 (14%)
		PLU-1	896..1229	CDD:285609	61/348 (18%)
		PHD2_KDM5A	1295..1351	CDD:277079	15/88 (17%)
		PHD3_KDM5A_like	1755..1805	CDD:277083
Kdm4a	XP_006238730.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345167
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840