Protein Alignment Kdm5 and Kdm5a

DIOPT Version :10

• Sequence 1: NP_523486.1
• Gene: Kdm5 / 33837
• FlyBaseID: FBgn0031759
• Length: 1838
• Species: Drosophila melanogaster
• Sequence 2: NP_001264106.1
• Gene: Kdm5a / 312678
• RGDID: 1305429
• Length: 1690
• Species: Rattus norvegicus
• Alignment Length: 1800
• Identity: 721/1800 - (40%)
• Similarity: 998/1800 - (55%)
• Gaps: 277/1800 - (15%)

  Fly   155 FDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRL 219
            |..|||||||.|:.|||.:||::|.:||.:|||.||.||.||..|.||||.:|...||.||||||
  Rat    13 FVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPPFACEVKTFRFTPRVQRL 77

  Fly   220 NELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKV 284
            |||||.|||:|:||||:|||||||||:||||:||||.||||.|.:||..:||.|..||::||:||
  Rat    78 NELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEIVTKEKKWSKV 142

  Fly   285 ANRMQYPSSKSVGATLKAHYERILHPFEVYTSG-KVLGPTPTSSGSGSTPVKLEDGG-------- 340
            .:|:.|...|..|:.||:||||||:|:|::.|| .::|            |::.|..
  Rat   143 GSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG------------VQMPDLDLKEKVEAE 195

  Fly   341 --GTDYK-AHEIPTRQQIAPPNETNTRRSKRFGNSNASCGLS-----GVTPTTKPSAGVFVKTET 397
              .||.: :.|..||..|.|......:.....|..|.:..|.     |..|..   .|:.|..:.
  Rat   196 VLSTDIQPSPERGTRMNIPPKRTRRVKSQSDSGEVNRNTELKKLQIFGAGPKV---VGLAVGAKD 257

  Fly   398 KEE---FKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALIVDPLMKYICHICNRGDV 459
            ||:   .:|.:.:..:|.|              ....|:||    .|.|:.:..|:|..|.||:.
  Rat   258 KEDEVTRRRKVTNRSDAFN--------------MQMRQRKG----TLSVNFVDLYVCMFCGRGNN 304

  Fly   460 EESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGFEQAEREYTLQQFGQM 524
            |:.:|||||||||||||||||||..:|||:|.||:||.||.:||:||||||||.||||||.||:|
  Rat   305 EDKLLLCDGCDDSYHTFCLLPPLPDVPKGDWRCPKCVAEECNKPREAFGFEQAIREYTLQSFGEM 369

  Fly   525 ADQFKQEYFRKPVHLVPTEMVEREFWRIVSSIDEDVTVEYGADLHTMDHGSGFPTK-SSLYLLPG 588
            ||.||.:||..|||:||||:||:||||:||||:|||.||||||:.:.|.|||||.| ....:||.
  Rat   370 ADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPIKDGQRKMLPE 434

  Fly   589 DQEYAESSWNLNNLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGE 653
            ::|||.|.|||||:|:||.|:|.|||.|||||..||:||||||::||||.|||||||||||||||
  Rat   435 EEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGE 499

  Fly   654 PKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVI 718
            ||||||||...|||.||.|::.|||||.||||||||||||||||:||.:.|||:||:|.|||||:
  Rat   500 PKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVV 564

  Fly   719 TFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHYSMLRRFCVFSHDELVCKMALEPAKLTF 783
            |||||||:||||||||||||||..||||.:||:|||||..|||.|||||:||:.|||.:|..|..
  Rat   565 TFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDV 629

  Fly   784 GIATACYIDMAEMVDTEKKLRKSLLEWGVTRAERRAFELVNDDERHCQECNTTCFLSAVACECND 848
            |:|.....::..|.:.|.:||:|:::.||..:|...||||.||||.|..|.|||||||:.|.||.
  Rat   630 GLAAMVCKELTLMTEEETRLRESVVQMGVVMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNP 694

  Fly   849 KLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMPLMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVT 913
            :.:|||.|.|.||.|..:...|.|||.|:::|.:|..:||:|.|::.|::|..:.:.|.......
  Rat   695 ERLVCLYHPTDLCSCPMQNKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVNRVTEALSASFNHKKD 759

  Fly   914 LQELQELCKEAETKKFPSSLLIDRLNAAAVEAEKCVTVIQQLGINKVRTRSDHNQEAAQYKLTME 978
            |.||:.:.::||.:|:|.:.|..:|..|..|||.|.:|.|.|...|.:.|...:....:.|||:|
  Rat   760 LIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCGSVAQLLLSKKQKHRQSSDSGKTRTKLTVE 824

  Fly   979 ELELFVQEIDNLCCIIDEGASVRELLVLGKQFVERSESQLQLSLESLEESELETLINEGSSLRIE 1043
            ||:.|||::.:|.|:|.:...|:.||...::|.||::..:.  .|:.:.|:|:.||:.||||.:|
  Rat   825 ELKAFVQQLVSLPCVISQTRQVKNLLDDVEEFHERAQEAMM--DETPDSSKLQVLIDMGSSLYVE 887

  Fly  1044 LQQLDLLQKRLKQCKWYKRSQGLRETSSKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQIGA 1108
            |.:|..|::.|:|.:|....:.......::|...:|.|:. :...|.|... |:|.|.:||::..
  Rat   888 LPELPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLID-SGVGLAPHHA-VEKAMAELQELLT 950

  Fly  1109 DIEAWESQAAKYFRRLTQQHELGEIEQFLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQN 1173
            ..|.|| :.||...:...:|.:..:|..:..|.:|...:|:...||:||:|||||...||.:|..
  Rat   951 VSERWE-EKAKVCLQARPRHSMANLENIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSG 1014

  Fly  1174 NHVTYCHTLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSD 1238
            ::..|...||::..:|..||::|:.|.:::..:.:|..|::.|...||||.:.:|||:||.||:|
  Rat  1015 SNYAYLEQLESLSAKGRPIPVRLDALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTD 1079

  Fly  1239 AINI---------------------DSDLKP--RFQDDFLKEKNPAEIVASFKHAEEQELLDMRE 1280
             |.:                     |.||:|  ..::...:.::.|.:||.||..|::|:..|..
  Rat  1080 -IGVYGSGKNRRKKVKEIIEKEKEKDLDLEPLSDLEEGLEETRDAAMVVAVFKEREQKEIEAMHS 1143

  Fly  1281 LRRQNMNKNPMRD-----MFCLCKSEFRNLMFNCQLCRDWFHEDCVPPPSATNQNGIVNGGSGPG 1340
            ||..|:.|..:.|     .||:|:......|..|:||:||||..|||.|.:.:|    ..||...
  Rat  1144 LRAANLAKMTIVDRIEEVKFCICRKTASGFMLQCELCKDWFHNGCVPLPKSGSQ----KKGSSWQ 1204

  Fly  1341 TNRPKWLCPSCVRSKRPRLETILPLLVQLQQLPIRLPEDEALRCLAERAMNWQDRARKALSSPDV 1405
            ....|:|||.|:||:||||||||.|||.||:||:||||.|||:||.||||:||||||:||::.::
  Rat  1205 AKDVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDRARQALATDEL 1269

  Fly  1406 SAAQEAI------MAQQQQKRRSEGGAGVGNISSPRKPRRRGSL-----------TKEASGS--- 1450
            |:|...:      |.:|..:.::|.........:...|..:|.|           ....|.|
  Rat  1270 SSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPHQ 1334

  Fly  1451 ------TESDADDD-------DDEDECRLR---IVEDNFSNDED--------------------- 1478
                  .|:|:|:|       |.:|...::   .:|.|...||:
  Rat  1335 AMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAE 1399

  Fly  1479 -------------------EPRTAP-ATSTVNSDLLKLLSDSEIENLLDLMMEGDLLEVSLDETQ 1523
                               :||.:| ...::...:|:|...::.: |.:|||.||||||||||||
  Rat  1400 HAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAKAQ-LEELMMVGDLLEVSLDETQ 1463

  Fly  1524 ELWRILE-TMPPTLLQAEAMERVVQYMQRQRQQHTNPLPTSGAEDSNDSLMVQNSPNSNSNSGGA 1587
            .:||||: |.||      :.:|.:..|:....:. .||...| :||::....:.........|..
  Rat  1464 HIWRILQATHPP------SEDRFLHIMEDDSVEE-KPLKMKG-KDSSEKKRKRKLEKVEQFFGEG 1520

  Fly  1588 TGSAS-----NSGRNKKRRSN-DTGGNSAVPRKKQSTPKQTPGKKGSAAAARKSDAKASPAASTT 1646
            .....     :..:.||.:.| |.........||.:..::...||..||||:...||.
  Rat  1521 KQKTKELKKIDKPKKKKLKLNVDKSKELNKLAKKLAKEEERKKKKEKAAAAKVELAKE------- 1578

  Fly  1647 PGADADAENKQANGGNTNSSTGSGGGNSATTTPTPGSTHKKRKRTSTTATNNNNNNNNNSTNNSN 1711
                                                ||.|||:|......:..:
  Rat  1579 ------------------------------------STEKKRERKVLDIPSKYD----------- 1596

  Fly  1712 SSTNLNSNTTSGQGAATGGNNATGGQKKHAQRSQQAAQEDDEEE--CRAENCHKPTGREVDWVQC 1774
                     .||                        |:|.|:|.  |.|:||.:|...:||||||
  Rat  1597 ---------WSG------------------------AEESDDENAVCAAQNCQRPCKDKVDWVQC 1628

  Fly  1775 DGGCNEWFHMYCVGLNRSQIKPDDDYICIRCTKTVAIGTQGSGHS 1819
            ||||:||||..|||:: .::..::|||||.|.|..  |....||:
  Rat  1629 DGGCDEWFHQVCVGVS-PEMAENEDYICINCAKKQ--GPDSPGHA 1670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm5	NP_523486.1	JmjN	160..201	CDD:128818	24/40 (60%)
		ARID_JARID	226..312	CDD:350628	54/85 (64%)
		PHD1_Lid_like	450..495	CDD:277078	30/44 (68%)
		JmjC	624..740	CDD:396791	93/115 (81%)
		zf-C5HC2	830..882	CDD:460750	26/51 (51%)
		PLU-1	896..1231	CDD:462475	105/334 (31%)
		PHD2_KDM5A	1295..1351	CDD:277079	22/55 (40%)
		PHD3_KDM5A_like	1755..1805	CDD:277083	27/51 (53%)
Kdm5a	NP_001264106.1	JmjN	18..59	CDD:128818	24/40 (60%)
		ARID_KDM5A	84..175	CDD:350637	55/90 (61%)
		PHD1_KDM5A	295..343	CDD:277075	32/47 (68%)
		JmjC	470..586	CDD:396791	93/115 (81%)
		zf-C5HC2	676..728	CDD:460750	26/51 (51%)
		PLU-1	741..1072	CDD:462475	105/335 (31%)
		PHD2_KDM5A	1163..1215	CDD:277079	22/55 (40%)
		PHD3_KDM5A	1608..1659	CDD:277156	27/51 (53%)