DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and Kdm5b

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_001100647.1	Gene:	Kdm5b / 304809	RGDID:	1565602	Length:	1544	Species:	Rattus norvegicus

Alignment Length:	1792	Identity:	690/1792 - (38%)
Similarity:	955/1792 - (53%)	Gaps:	309/1792 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 EPSTPVTPAGATGSHTHAPPGISPAVMERPMPSVPMNHASSSVSASKKYHNSCPHPTPTPAPTGH 131
            ||:|.:            |||        |.|::|:.                     .|.|.|
  Rat     2 EPATAL------------PPG--------PRPALPLG---------------------GPGPLG- 24

  Fly   132 KKSVHTQPHSSNKFDQGKNEEFHFDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPP 196
                                  .|..|||||||.|:.|||.:|.|:|.|||.|||:.||.|:.||
  Rat    25 ----------------------EFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPP 67

  Fly   197 ATWSPPFAVDVDKLRFVPRVQRLNELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYT 261
            ..|.||||.|||||.|.||:||||||||:|||||||||||||:||||||:||||.||||.|||:.
  Rat    68 PDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKIPHVERKILDLFQ 132

  Fly   262 LHRIVQEEGGMEQTTKDRKWAKVANRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVL----GP 322
            |:::|.||||.....|||||.|:|.:|.:...|:||:.::.||||||:|:.::.||..|    .|
  Rat   133 LNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLFLSGDSLRCLQKP 197

  Fly   323 TPTSSGSGSTPVKLEDGGGTDYKAHEIPTRQQIAPPNET--NTRRSKRFGNSNASCGLSGVTPTT 385
            ..||           |....:||.|:||.||.: .|:||  ..||:||.       ....:....
  Rat   198 NLTS-----------DTKDKEYKPHDIPQRQSV-QPSETCPPARRAKRM-------RAEAMNIKI 243

  Fly   386 KPSAGVFVKTET----------KEEFKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPA 440
            :|......:|..          |.|.::::.|:.....:........:..:...:..||    .|
  Rat   244 EPEEATEARTHNLRRRMGCATPKRENEKEVKSTIKQEPTEKKDCVLESEKDKPKSRAKK----TA 304

  Fly   441 LIVDPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQE 505
            ..||   .|:|.:|..|:.|:.:|||||||||||||||||||..:|||:|.||:|:.:|.|||||
  Rat   305 TAVD---LYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLLPPLHDVPKGDWRCPKCLAQECSKPQE 366

  Fly   506 AFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVSSIDEDVTVEYGADLHT 570
            |||||||.|:|||:.||:|||.||.:||..|||:||||:||:||||:||:|:||||||||||:.:
  Rat   367 AFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIAS 431

  Fly   571 MDHGSGFPTK-SSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMNAPWMYVGMCFAAF 634
            .:.|||||.: ..:.:.|.::||.:|.|||||:|::|.|:|.||.|||.||..||:||||||::|
  Rat   432 KEFGSGFPVRDGKIKISPEEEEYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSF 496

  Fly   635 CWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLHQLVTIMNPNIL 699
            |||.||||||||||||||||||||||||..|||.|..||:.|||||.||||||||||||||||.|
  Rat   497 CWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTL 561

  Fly   700 MNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHYSMLRRFCV 764
            |.:.|||:||:|.|||||||||||||:|||||:||||||||...|||.:||:||.||.:|.|:||
  Rat   562 MTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCV 626

  Fly   765 FSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAERRAFELVNDDERH 829
            |||||::||||.:...|...:|:....|||.|::.||.||:::.:.||..:||..|||:.||||.
  Rat   627 FSHDEMICKMASKADVLDVVVASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQ 691

  Fly   830 CQECNTTCFLSAVACECNDKLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMPLMLQKLKVKAHSFE 894
            |.:|.||||:||::|.|...|:|||.|...||.|.|.|:.|.||||||::..|:..||::|.|:.
  Rat   692 CIKCKTTCFMSAISCSCKPGLLVCLHHVKELCSCPPYKYNLRYRYTLDDLYPMMNALKLRAESYN 756

  Fly   895 RWLSRCRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLIDRLNAAAVEAEKCVTVIQQLGINK 959
            .|.....:.::|......:|...:.|.:|:|.||||.:.|:..|.....:||||.:|.|||...|
  Rat   757 EWALNVNEALEAKINKKKSLVSFKALIEESEMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGK 821

  Fly   960 VRTRSDHNQEAAQYKLTMEELELFVQEIDNLCCIIDEGASVRELLVLGKQFVERSESQLQLSLES 1024
            .:||.......:|.:||:.||..||.::..|.|::.:...:::||...:.|  :.:||..||.|.
  Rat   822 RQTRYRSGGGKSQSQLTVNELRQFVTQLCALPCVLSQTPLLKDLLNRVEDF--QQQSQRLLSEER 884

  Fly  1025 LEESELETLINEGSSLRIELQQLDLLQKRLKQCKWYKRSQGLRETSSKLTYQDVKNLLHIAAADL 1089
            ...|||:.|::...:..:||.||..::.||:|.:|.:..|.....||.|:..|::.|:.:...
  Rat   885 PRASELQQLLDVSFTFDVELPQLAEMRIRLEQARWLEEVQQACLDSSSLSLDDMRRLIDLGVG-- 947

  Fly  1090 DPTDPY--VDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHELGEIEQFLKSASDINGQVPSHGL 1152
              ..||  |:|.|.:||::....|.|:.: ||...|...:|.|..:...:|...:|...:|:..:
  Rat   948 --LAPYSAVEKAMARLQELLTVSEHWDDK-AKSLLRARPRHSLSSLATAVKEMEEIPAYLPNGTV 1009

  Fly  1153 LKDALRKAREWLRAVEQLQQNNHVTYCHTLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDNTA 1217
            |||:::|||:|::.|:.||....|....||..::.||.:||:.|..|.|::..::..|.||::.|
  Rat  1010 LKDSVQKARDWVQDVDALQAGGRVPVLETLIELVARGRSIPVHLNSLPRLEMLVSEVHAWKESAA 1074

  Fly  1218 CAFLKKGTFYTLLEVLMPRSDAINIDSDLKPRFQDDFL---------------------KEKNPA 1261
            ..||.:.:.|:|||||.||.|...:....|.|...|.|                     :.|..|
  Rat  1075 KTFLLENSPYSLLEVLCPRCDIGLLGLKRKQRKLKDPLPSGKKRSTKLESLSDLERALTESKETA 1139

  Fly  1262 EIVASFKHAEEQELLDMRELRRQNMNK--NPMRDM---FCLCKSEFRNLMFNCQLCRDWFHEDCV 1321
            ..:|:...|..:|:..::.||..|..|  :|.:|:   .|||:......|..|:||||.||..||
  Rat  1140 SAMATLGEARLREMEALQSLRFANEEKLLSPAQDVETKVCLCQKTPATPMIQCELCRDAFHTSCV 1204

  Fly  1322 PPPSATNQNGIVNGGSGPGTNRPKWLCPSCVRSKRPRLETILPLLVQLQQLPIRLPEDEALRCLA 1386
            ...|.:..:.|             ||||.|.||::|.||.|||||..||::.:||||.:|||.:.
  Rat  1205 AVSSISQSSRI-------------WLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMI 1256

  Fly  1387 ERAMNWQDRARKALSSPDVSAAQEAIMAQQQQKRRSEGGAGVGNISSPRKPRRRGSLT-----KE 1446
            ||.:|||.||::.|||.::...|:.              ||.|.:.| |.|...|:.:     .:
  Rat  1257 ERTVNWQHRAQQLLSSGNLKLVQDQ--------------AGSGLLFS-RWPASAGTASAADKVSQ 1306

  Fly  1447 ASGSTESDADDDDDEDECRLRIVEDNFSNDEDEPRTAPATSTVNSDLLKLLSDSEIENLLDLMME 1511
            ..|:|.....:|.|.   |...:...||..:........:..||                :|:||
  Rat  1307 PPGTTSFSLPEDWDN---RTSYLHSPFSTGQSCIPLHGLSPEVN----------------ELLME 1352

  Fly  1512 GDLLEVSLDETQELWRILETMPPTLLQAEAMERVVQYMQRQRQQHTNPLPTSGAEDSNDSLMVQN 1576
            ..||:|||.|.|||::.|.|.|.:..||:...                 |...:.:.||.|.
  Rat  1353 AQLLQVSLPEVQELYQTLLTKPSSAQQADRSS-----------------PVRPSSEKNDCLR--- 1397

  Fly  1577 SPNSNSNSGGATGSASNSGRNKKRRSNDTGGNSAVPRKKQSTPK--QTPGKKGSAAAARKSDAKA 1639
                     |...:.::..|..|||....|    :|.::....|  :||.||....:..|
  Rat  1398 ---------GKRDAINSLERKLKRRPEREG----LPSERWDRVKKMRTPQKKKIKLSHPK----- 1444

  Fly  1640 SPAASTTPGADADAENKQANGGNTNSSTGSGGGNSATTTPTPGSTHKKRKRTSTTATNNNNNNNN 1704
                        |..|.:.                            :|:|:.....|...:
  Rat  1445 ------------DMNNFKL----------------------------ERERSYDLVRNAETH--- 1466

  Fly  1705 NSTNNSNSSTNLNSNTTSGQGAATGGNNATGGQKKHAQRSQQAAQEDDEEECRAENCHKPTGREV 1769
                      :|.|:|:                     .|:|...||::..|.|.:|.:|.|.||
  Rat  1467 ----------SLPSDTS---------------------YSEQEDSEDEDAICPAVSCLQPEGDEV 1500

  Fly  1770 DWVQCDGGCNEWFHMYCVGLNRSQIKPDDDYICIRCT 1806
            |||||||.||:|||..|||:: .::...:||||:|||
  Rat  1501 DWVQCDGSCNQWFHQVCVGVS-PEMAEKEDYICVRCT 1536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	24/40 (60%)
		ARID	227..312	CDD:198082	53/84 (63%)
		PHD1_Lid_like	450..495	CDD:277078	29/44 (66%)
		JmjC	624..740	CDD:202224	94/115 (82%)
		zf-C5HC2	830..882	CDD:280996	27/51 (53%)
		PLU-1	896..1229	CDD:285609	102/334 (31%)
		PHD2_KDM5A	1295..1351	CDD:277079	19/55 (35%)
		PHD3_KDM5A_like	1755..1805	CDD:277083	26/49 (53%)
Kdm5b	NP_001100647.1	JmjN	31..72	CDD:128818	24/40 (60%)
		BRIGHT	98..188	CDD:128777	53/89 (60%)
		PHD1_KDM5B	311..356	CDD:277076	29/44 (66%)
		JmjC	486..602	CDD:202224	94/115 (82%)
		zf-C5HC2	692..744	CDD:280996	27/51 (53%)
		PLU-1	757..1086	CDD:285609	102/335 (30%)
		PHD_SF	1178..1221	CDD:304600	19/55 (35%)
		HARE-HTH	<1416..1501	CDD:294801	26/167 (16%)
		PHD3_KDM5B	1486..1535	CDD:277157	26/49 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345166
Domainoid	1	1.000	221	1.000	Domainoid score	I2516
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1244	1.000	Inparanoid score	I166
OMA	1	1.010	-	-		QHG53001
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	1	1.000	-	-		FOG0000761
OrthoInspector	1	1.000	-	-		otm44795
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910