DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lid and Kdm4b

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_001037701.2	Gene:	Kdm4b / 301128	RGDID:	1588576	Length:	1099	Species:	Rattus norvegicus

Alignment Length:	293	Identity:	96/293 - (32%)
Similarity:	139/293 - (47%)	Gaps:	43/293 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   485 IPKGEWLCPRCVVEEVSK-------PQEAFGFEQAEREYTLQQFGQMADQFKQ----EYFRKPVH 538
            ||..||. ||...:::..       .|...|......:|.:|:......::::    |.:..|.|
  Rat    49 IPPKEWK-PRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRH 112

  Fly   539 LVPTEMVEREFWR---IVSSIDEDVTVEYGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNLN 600
             ...:.:||::|:   .||.|       ||||:      ||     |||    |.:.|:  ||:.
  Rat   113 -QDFDDLERKYWKNLTFVSPI-------YGADI------SG-----SLY----DDDVAQ--WNIG 152

  Fly   601 NLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCA 665
            ||..:.|.:.......|.|:|.|::|.||....|.||.||...|||||||:||||:||.:|....
  Rat   153 NLRSILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHG 217

  Fly   666 EQFEETMKQAAPELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQ 730
            ::.|.......|.........|...:|:::|.||....:|..|..|.||||:||||..||||||.
  Rat   218 KRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNH 282

  Fly   731 GYNFAEAVNFAPADWLKMGR---ECVNHYSMLR 760
            |:|.||:.|||...|:..|:   :|.....|::
  Rat   283 GFNCAESTNFATLRWIDYGKVATQCTCRKDMVK 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818
		ARID	227..312	CDD:198082
		PHD1_Lid_like	450..495	CDD:277078	5/9 (56%)
		JmjC	624..740	CDD:202224	50/115 (43%)
		zf-C5HC2	830..882	CDD:280996
		PLU-1	896..1229	CDD:285609
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
Kdm4b	NP_001037701.2	JmjN	15..56	CDD:128818	4/7 (57%)
		JmjC	176..292	CDD:396791	50/115 (43%)
		AvrE	475..>671	CDD:338078
		PHD_SF	686..789	CDD:419867
		ePHD_JMJD2B	798..907	CDD:277184
		Tudor_JMJD2B_rpt1	920..973	CDD:410535
		Tudor_SF	977..1032	CDD:413384
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345173
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840