DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and jmj2

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_593492.1	Gene:	jmj2 / 2543275	PomBaseID:	SPAC1002.05c	Length:	715	Species:	Schizosaccharomyces pombe

Alignment Length:	825	Identity:	252/825 - (30%)
Similarity:	381/825 - (46%)	Gaps:	157/825 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 YHNSCP------HPTP--TPAPTGHKKSVHTQPHSSNKFDQGKNEEFHFDTPPECPVFRPTTEEF 171
            :|.:.|      |.|.  .|||.|.....:.....|....|.|.........|..|||.|..|||
pombe     6 FHQTSPSFVQYTHATDKLKPAPHGMNTRGNNLSSMSKNTGQRKQRSKSIHGLPVAPVFYPDKEEF 70

  Fly   172 KNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRLNELEAKTRVKLNFLDQI 236
            ::.:.||:||..|.||.||.||:|||.|:||..:|::|..|..|.|.|:.::.:.|..:::.:::
pombe    71 QDSIGYINKIAPIGEKYGIIKIVPPAGWNPPMQLDMNKFSFRTRRQDLHMMDLRFREIVSYDERV 135

  Fly   237 AKFWELQGSSLKIP---MVERKALDLYTLHRIVQEEGGM-EQTTKDRKWAKVANRMQYPSSKSVG 297
            .:|:...|  :::|   .:...::|||:|.|.:.....: |:..|...|.::...:..|.:   .
pombe   136 YRFFCNLG--MELPESFFISNTSIDLYSLMRCIDSHASLSEKELKVHVWKRILRELSIPFT---N 195

  Fly   298 ATLKAH---YERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEIP---TRQQIA 356
            |:||..   |.|.:.|||.:..                  |.:......::....|   |:.:.:
pombe   196 ASLKEASDLYLRYIFPFEDFVR------------------KYQTSEDQCFETDLFPKFFTKDEHS 242

  Fly   357 PPNETNTRRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETK--EEFKRDLL------SSFNAVN 413
            ..:..:.:.||:|            .|.|..|.|:....|:|  |:.|:..:      |:.|..:
pombe   243 NISIKDQKTSKQF------------NPETNESVGILQNQESKRNEQIKQQYMPADNFGSNDNHSH 295

  Fly   414 SGGSPLATGTTANTRGASQKKGGEPPALIVDPLMKYICHICNRG---DVEESMLLCDGCDDSYHT 475
            :....|::.:|.|                     .::|..|::.   :||      |.|.::|
pombe   296 NKKRRLSSLSTNN---------------------NHLCDNCHKPVNCEVE------DTCKEAY-- 331

  Fly   476 FCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLV 540
                            |.:|::    .|.| ||||.. ..|||..|.:..|.||:.||.|.....
pombe   332 ----------------CTKCII----NPYE-FGFETG-NYYTLSNFEKYCDNFKKNYFSKFKDSE 374

  Fly   541 PTE-MVEREFWRIVSSIDEDVTVEYGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNLNNLPL 604
            .|| :||:|:|::|...:..:.|||||||.|:|.||.||:.:...:.|    |::.:||||.:..
pombe   375 ITEDIVEKEYWKLVKDNNTSLEVEYGADLSTLDQGSAFPSLAKNPVNP----YSKDTWNLNVIAS 435

  Fly   605 LEDSILGHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFE 669
            ...|:|.:|:..:||:..||:||||||:.||||.||:::||:||.|:|:.|.|||:||..||:||
pombe   436 TNGSLLSYIDNPVSGITCPWLYVGMCFSTFCWHVEDNYTYSVNYQHYGDTKLWYGIPGDQAERFE 500

  Fly   670 ETMKQAAPELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNF 734
            ......||:|...|.|||:||.|::||:.|....|.|:..||...|||||||:::|||.|.|:|.
pombe   501 RAALDIAPDLVKKQKDLLYQLATMINPDELQKRGVDVYFIDQGPNEFVITFPKSFHAGINHGFNI 565

  Fly   735 AEAVNFAPADWLKMGREC--VNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMV 797
            .|||||||.|||..|...  |..|..|.:..|.|||.||..:|..||.         .|.::|:.
pombe   566 NEAVNFAPKDWLLNGFSLNGVLKYQSLLKPPVLSHDMLVYNLATNPAS---------EISVSELR 621

  Fly   798 DTEKKLRKSLLEWGVTRAERRAF--------ELVNDDER-HCQECNTTCFLSAVACECNDKLIVC 853
            ....:..|.  |.|:....|..:        ||:.|.|. .||.|....:.|.|||.|. .:.||
pombe   622 PWVHEAVKR--ELGIRIMIRGRYDLKEILYRELMEDAENWQCQHCKAFSYFSQVACSCK-SITVC 683

  Fly   854 LRHYTVLCGCAPEKHTLIYRYTLDEMPLMLQKLKVKAHSFERWLS 898
            ..|...||.|.....||              :|||..:..::.||
pombe   684 PLHIEYLCKCDLSNKTL--------------RLKVDDNELQKLLS 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	22/40 (55%)
		ARID	227..312	CDD:198082	19/91 (21%)
		PHD1_Lid_like	450..495	CDD:277078	8/47 (17%)
		JmjC	624..740	CDD:202224	62/115 (54%)
		zf-C5HC2	830..882	CDD:280996	16/51 (31%)
		PLU-1	896..1229	CDD:285609	2/3 (67%)
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
jmj2	NP_593492.1	JmjN	59..100	CDD:128818	22/40 (55%)
		BRIGHT	126..218	CDD:128777	21/114 (18%)
		JmjC	455..571	CDD:202224	62/115 (54%)
		zf-C5HC2	661..712	CDD:280996	19/65 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	150	1.000	Domainoid score	I1101
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000761
OrthoInspector	1	1.000	-	-		oto100738
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R628
SonicParanoid	1	1.000	-	-		X397
TreeFam	0	0.000	Not matched by this tool.
	9	8.840