Protein Alignment Kdm5 and msc1

DIOPT Version :10

• Sequence 1: NP_523486.1
• Gene: Kdm5 / 33837
• FlyBaseID: FBgn0031759
• Length: 1838
• Species: Drosophila melanogaster
• Sequence 2: NP_593431.1
• Gene: msc1 / 2541710
• PomBaseID: SPAC343.11C
• Length: 1588
• Species: Schizosaccharomyces pombe
• Alignment Length: 1811
• Identity: 341/1811 - (18%)
• Similarity: 602/1811 - (33%)
• Gaps: 525/1811 - (28%)

  Fly   166 PTTEEFKNPLAYISKI-RSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRLNELEAKTRVK 229
            |..|||...|.:||.: ...|.|.|..:::||..|..|..::....:|:.|....:.:...:...
pombe    87 PKKEEFSRGLDFISDLYDQTARKSGAVRVIPPDNWKCPLTINTTTFKFLTRKNNPSSMSLVSNYP 151

  Fly   230 LNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKVANRMQYPSSK 294
            |:.:....||                       |       |.::|.:........|:....:..
pombe   152 LDAISSQQKF-----------------------H-------GNDKTLEKNSAKATINKSNSTAET 186

  Fly   295 SVGATLKAHYERILHP-FE---------VYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEI 349
            |..||::.:....|:. |:         ::..||.              |.|            :
pombe   187 SSTATVEPYDSNDLYRIFDRPDAVVLSYIFVLGKA--------------VDL------------L 225

  Fly   350 PTRQQIAPPNETNTRRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNS 414
            ..:|.:....:.|....:.:                         ::..:.:|.|:.|..||.|.
pombe   226 QIKQWLQLSKQKNLLEFEFW-------------------------SQAAQHYKLDVNSLRNAYNL 265

  Fly   415 GGSPLATGTTANTRGASQKKGGEP---PALIV---DPLMKYICHICNRGDVEESMLLCDGCDDSY 473
            ...   ||.|..|    ...||.|   ||..|   :.:.|  |.:|  .....|::.|..|..:|
pombe   266 YAE---TGVTTRT----GNDGGSPINRPAKRVKRQNHIPK--CKLC--AQEGSSLVTCCICQSNY 319

  Fly   474 HTFCLLPPLTSIPKGE---WLCPRCVVEEVSKPQEAFGFEQAEREY-----TLQQFGQMADQFKQ 530
            |..|:..|..  |..:   |.|..|:...:.       ....|.:|     .||...::|...|:
pombe   320 HYACVEAPFA--PFSDIHYWTCNSCIPSSLK-------ILWKEVDYHCISSFLQSSNELASSLKK 375

  Fly   531 EYFRKPVHLVPTEMV-----------EREFWRIVSS-----IDEDVTVEYGADLHTMDHGS---- 575
            :.   |..|..|.:.           .|:..|...|     .:..:::...:|:..::..|
pombe   376 QL---PSFLAQTPLTLPSNTKTPPASARQSSRRTRSTSGKGFETKISINLDSDIKLLNTLSPLET 437

  Fly   576 -----GFPTKSS----------------------LYLLPGDQE--YAESSWNL-----NNLPLLE 606
                 .||:.:|                      ....|..::  |....|||     :.|..|.
pombe   438 FFWCCSFPSTASTSSPFSYYPESLPTPLLGRAVNTTAFPTSRQNAYYNDPWNLYFIHFSKLSPLR 502

  Fly   607 DSILGHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEET 671
            .:..|.:.:.||        :|.......|..:....:.::|.|:|..:.||.:|.....::|:.
pombe   503 FTPPGILTSTIS--------LGQPLTCQGWQRDSMSLFGMHYHHYGAQRIWYVIPEVDGPKYEKL 559

  Fly   672 MKQAAPELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAE 736
            :...:|.....:|:.|.:...::..::|::|.:.|....|::.|||||.|..|:...:.|::.:|
pombe   560 LNDLSPSFIQEKPETLIKSKILLPISMLISNGIQVLTFVQNSNEFVITSPNTYYTVLDTGFSLSE 624

  Fly   737 AVNFAPADWLK--MGRECVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYI--DMAEMV 797
            :|.||..:|::  ......|.|..|.....||.|.::    |..|.|...:.:|.::  .:.:.|
pombe   625 SVPFATKEWIQDMHAENSFNMYKNLHISAPFSLDHIL----LANATLDKTVHSAYWLMTCLKDRV 685

  Fly   798 DTEKKLRKS------LLEWGVTRAERRAFELVNDDERHCQECNTTCFLSAVACECNDKLIVCLRH 856
            |.|..||..      ||.|..|..|.....        |..|.|..:|:::. |.|.....||.|
pombe   686 DRELTLRNEFRKRHPLLTWIPTPLESSVMA--------CAFCKTFAYLASIE-EKNGTKTACLSH 741

  Fly   857 YTVLCGCAPEKH---TLIYRYTLDEMPLMLQKLKVKAHSFERWLSRCRDIV--DAHTPTSVTLQE 916
            ..   .|.|...   |::.||..:.:.....|:..:||..:.||...::.:  |...|   :|:.
pombe   742 KD---ECFPNTDSDLTVLVRYDDNALLAAYSKVVERAHKADTWLENYKEALGSDNSRP---SLKV 800

  Fly   917 LQELCKEAETKKFP---SSLLIDRLNAAAVEAEKCVTVIQQLGINKVRTRSDHNQEAAQYKLTME 978
            |:.|..||||...|   .||:.:.:..|....:|...:.::..:.|...|......|     |..
pombe   801 LKTLLNEAETICCPLQEVSLVRNLVKTAQQWLDKFAIIFKKKSMVKKEKRKPKRGSA-----THS 860

  Fly   979 ELELFVQEIDNL-CCIIDEGASVRELLVLGKQFV----------ERSESQLQLSLE--------S 1024
            .||...:|:::| ...|:|...:..|:...:||.          |::|| |::..|        |
pombe   861 HLESPSEEVEDLNSSNINEADLLINLVEEAEQFTFDFPEMAVAFEKAES-LKIFREKANAMKERS 924

  Fly  1025 LEESELETLINEGSSLRIELQQLDLLQKRLKQCKWYKR-SQGLRETSSKLTYQDVKNLLHIAAAD 1088
            |...|...::.||.||:::..:|...::.:::.:|... :|..::|.|  |.:::..|:......
pombe   925 LSYEECLAIVEEGESLQLKTPELLYFKQYMEKTEWIDSFNQISQKTDS--TMEELVELIERGEKI 987

  Fly  1089 LDPTDPYVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHELGEIEQF-LKSASDINGQVPSHGL 1152
            ...:|   ::.|.....:....|.|..|.    ..|..|..|...:.| ||  |:.|....:.||
pombe   988 GLTSD---NENMATALLLKEKSENWMKQV----EGLLSQETLSTSKLFQLK--SEANSICINRGL 1043

  Fly  1153 LKDALRKAREWLRAVEQLQQNNHVTYCH--------------TLE---AMIERGLNIPIQLEELS 1200
            |        |.|..|.|..:|.|.....              |:|   .::....|:..:.||.:
pombe  1044 L--------EQLNEVLQKSENFHTQLVSLISRARDPDYYSRPTIEEAKTVLAESENLTNKPEEYT 1100

  Fly  1201 RMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINIDSDLKPRFQDDFLKEKNPAEIV- 1264
            ..|..|...::|.......|   |.....||:.....               :|::::|...:|
pombe  1101 VAQKLLTQTYEWVRRGKRLF---GKANAPLEIFNQHL---------------EFVEQRNTNAMVD 1147

  Fly  1265 ----ASFKHAEEQELLDMRELRRQNMNKNPMRDMFCLCKSEFRNLMFNCQLCRDWFHEDCVPPPS 1325
                |.|....|..::         ...:|....:|.|:.....:|..|:||.:|:|..|:....
pombe  1148 EGSDAPFHVGNEYYVI---------AGSDPSDFHYCFCRQPEAGMMIECELCHEWYHAKCMKMSK 1203

  Fly  1326 ATNQNGIVNGGSGPGTNRPKWLCPSC-VRSKRPRLETILPLLVQLQQ-------LPIRLPEDEAL 1382
            ...:..            .|::||.| .|.:.|| .:..|.|::||:       ||.:..|.|.|
pombe  1204 KKLRAD------------EKFICPICDYRVEVPR-HSHRPPLIELQKMVDDIPTLPFQPIEIELL 1255

  Fly  1383 RCLAERAMNWQDRARKALSSPDVSAAQEAIMAQQQQKRRSEGGAGVGNISSPRKPRRRGSLTKEA 1447
            :.:.::|..::::.:..:..| ...:::.:...|...|:.||
pombe  1256 KRVVKQAEEFKNKMQSEVCDP-TQLSEKDVPLLQFYLRKLEG----------------------- 1296

  Fly  1448 SGSTESDADDDDDEDECRLRIVEDNFSNDEDEPRTAPATSTVNSDLLKLLSDSEIENLLDLMMEG 1512
                                                                |||     |..|.
pombe  1297 ----------------------------------------------------SEI-----LFTEE 1304

  Fly  1513 DLLEVSLDETQELWRILETMPPTLLQAEAMERVVQYMQRQRQQHTNPLPTSGAEDSNDSLMVQNS 1577
              |.|...:..|...:....||.:              .:.:.:..|.||....:    :|.|..
pombe  1305 --LNVFRQKLHEFMPVAPQPPPFI--------------GESRSNRKPRPTKRQRE----IMEQVE 1349

  Fly  1578 PNSNSNSGGATGSASNSGRNKKRRSNDTGGNSAVPRKKQSTPKQTPGKKGSAAAARKSDAKASPA 1642
            ....:::.||...|:...||:         |:.:.:........|.    .:..|.||.|:|:.:
pombe  1350 SGKLTSAEGAAAIAATQTRNQ---------NNFISKPFNVHTLSTT----LSPWAMKSLAQAAIS 1401

  Fly  1643 ASTTPGADADAENKQANGGNTNSSTGSGGGNSATTTPTPGSTHKKRKRTSTTATNNNNNNNNNST 1707
            .:..|.|                       :....|..|....                     |
pombe  1402 PNPMPSA-----------------------HDLLPTSNPAELF---------------------T 1422

  Fly  1708 NNSNSSTNLNSNTTSGQGAATGGNNATGGQKKHAQRSQQAAQEDDEEECRAENCHKPTGREVDWV 1772
            |.|.....|:.::||    ..||.|::     |....|.|:     ..|.   |.:|.......|
pombe  1423 NISPEIKELSVDSTS----TLGGLNSS-----HLVSDQNAS-----VICL---CRQPFAISDGTV 1470

  Fly  1773 QCDGGCNEWFHMYCVGLNRSQIKPDDDYICIRCTKTVAIGTQGSGHSMSVASTTTP 1828
            ||. .|.||||..||||:...:....:|.|..|     ...:|..:..:....:||
pombe  1471 QCH-NCLEWFHYECVGLSSDIVSTLSNYACPDC-----CSKEGKLYPWNTRPRSTP 1520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm5	NP_523486.1	JmjN	160..201	CDD:128818	13/35 (37%)
		ARID_JARID	226..312	CDD:350628	11/86 (13%)
		PHD1_Lid_like	450..495	CDD:277078	12/47 (26%)
		JmjC	624..740	CDD:396791	26/115 (23%)
		zf-C5HC2	830..882	CDD:460750	14/54 (26%)
		PLU-1	896..1231	CDD:462475	80/377 (21%)
		PHD2_KDM5A	1295..1351	CDD:277079	12/55 (22%)
		PHD3_KDM5A_like	1755..1805	CDD:277083	17/49 (35%)
msc1	NP_593431.1	JmjN	80..123	CDD:128818	13/35 (37%)
		PHD_SF	299..342	CDD:276966	12/46 (26%)
		JmjC	513..628	CDD:396791	28/122 (23%)
		zf-C5HC2	716..764	CDD:460750	14/51 (27%)
		PLU-1	780..1131	CDD:462475	82/381 (22%)
		PHD_Ecm5p_Lid2p_like	1173..1217	CDD:276993	12/55 (22%)
		PHD_SF	1457..1502	CDD:473978	17/48 (35%)