DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and msc1

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_593431.1	Gene:	msc1 / 2541710	PomBaseID:	SPAC343.11c	Length:	1588	Species:	Schizosaccharomyces pombe

Alignment Length:	1807	Identity:	344/1807 - (19%)
Similarity:	601/1807 - (33%)	Gaps:	517/1807 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 PTTEEFKNPLAYISKI-RSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRLNELEAKTRVK 229
            |..|||...|.:||.: ...|.|.|..:::||..|..|..::....:|:.|....:.:...:...
pombe    87 PKKEEFSRGLDFISDLYDQTARKSGAVRVIPPDNWKCPLTINTTTFKFLTRKNNPSSMSLVSNYP 151

  Fly   230 LNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKVANRMQYPSSK 294
            |:.:....||                       |       |.::|.:........|:....:..
pombe   152 LDAISSQQKF-----------------------H-------GNDKTLEKNSAKATINKSNSTAET 186

  Fly   295 SVGATLKAH-----YERILHPFEVYTSG-KVLGPTPTSSGSGSTPVKLEDGGGTDYKAHE-IPTR 352
            |..||::.:     |.....|..|..|. .|||                       ||.: :..:
pombe   187 SSTATVEPYDSNDLYRIFDRPDAVVLSYIFVLG-----------------------KAVDLLQIK 228

  Fly   353 QQIAPPNETNTRRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGS 417
            |.:....:.|....:.:                         ::..:.:|.|:.|..||.|....
pombe   229 QWLQLSKQKNLLEFEFW-------------------------SQAAQHYKLDVNSLRNAYNLYAE 268

  Fly   418 PLATGTTANTRGASQKKGGEP---PALIVDPLMKYI--CHICNRGDVEESMLLCDGCDDSYHTFC 477
               ||.|..|    ...||.|   ||..| ....:|  |.:|  .....|::.|..|..:||..|
pombe   269 ---TGVTTRT----GNDGGSPINRPAKRV-KRQNHIPKCKLC--AQEGSSLVTCCICQSNYHYAC 323

  Fly   478 LLPPLTSIPKGE---WLCPRCVVEEVSKPQEAFGFEQAEREY-----TLQQFGQMADQFKQEYFR 534
            :..|..  |..:   |.|..|:...:.       ....|.:|     .||...::|...|::.
pombe   324 VEAPFA--PFSDIHYWTCNSCIPSSLK-------ILWKEVDYHCISSFLQSSNELASSLKKQL-- 377

  Fly   535 KPVHLVPTEMV-----------EREFWRIVSS-----IDEDVTVEYGADLHTMDHGS-------- 575
             |..|..|.:.           .|:..|...|     .:..:::...:|:..::..|
pombe   378 -PSFLAQTPLTLPSNTKTPPASARQSSRRTRSTSGKGFETKISINLDSDIKLLNTLSPLETFFWC 441

  Fly   576 -GFPTKSS----------------------LYLLPGDQE--YAESSWNL-----NNLPLLEDSIL 610
             .||:.:|                      ....|..::  |....|||     :.|..|..:..
pombe   442 CSFPSTASTSSPFSYYPESLPTPLLGRAVNTTAFPTSRQNAYYNDPWNLYFIHFSKLSPLRFTPP 506

  Fly   611 GHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQA 675
            |.:.:.||        :|.......|..:....:.::|.|:|..:.||.:|.....::|:.:...
pombe   507 GILTSTIS--------LGQPLTCQGWQRDSMSLFGMHYHHYGAQRIWYVIPEVDGPKYEKLLNDL 563

  Fly   676 APELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNF 740
            :|.....:|:.|.:...::..::|::|.:.|....|::.|||||.|..|:...:.|::.:|:|.|
pombe   564 SPSFIQEKPETLIKSKILLPISMLISNGIQVLTFVQNSNEFVITSPNTYYTVLDTGFSLSESVPF 628

  Fly   741 APADWLK--MGRECVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYI--DMAEMVDTEK 801
            |..:|::  ......|.|..|.....||.|.::    |..|.|...:.:|.::  .:.:.||.|.
pombe   629 ATKEWIQDMHAENSFNMYKNLHISAPFSLDHIL----LANATLDKTVHSAYWLMTCLKDRVDREL 689

  Fly   802 KLRKS------LLEWGVTRAERRAFELVNDDERHCQECNTTCFLSAVACECNDKLIVCLRHYTVL 860
            .||..      ||.|..|..|.....        |..|.|..:|:::. |.|.....||.|..
pombe   690 TLRNEFRKRHPLLTWIPTPLESSVMA--------CAFCKTFAYLASIE-EKNGTKTACLSHKD-- 743

  Fly   861 CGCAPEKH---TLIYRYTLDEMPLMLQKLKVKAHSFERWLSRCRDIV--DAHTPTSVTLQELQEL 920
             .|.|...   |::.||..:.:.....|:..:||..:.||...::.:  |...|   :|:.|:.|
pombe   744 -ECFPNTDSDLTVLVRYDDNALLAAYSKVVERAHKADTWLENYKEALGSDNSRP---SLKVLKTL 804

  Fly   921 CKEAETKKFP---SSLLIDRLNAAAVEAEKCVTVIQQLGINKVRTRSDHNQEAAQYKLTMEELEL 982
            ..||||...|   .||:.:.:..|....:|...:.::..:.|...|......|     |...||.
pombe   805 LNEAETICCPLQEVSLVRNLVKTAQQWLDKFAIIFKKKSMVKKEKRKPKRGSA-----THSHLES 864

  Fly   983 FVQEIDNL-CCIIDEGASVRELLVLGKQFV----------ERSESQLQLSLE--------SLEES 1028
            ..:|:::| ...|:|...:..|:...:||.          |::|| |::..|        ||...
pombe   865 PSEEVEDLNSSNINEADLLINLVEEAEQFTFDFPEMAVAFEKAES-LKIFREKANAMKERSLSYE 928

  Fly  1029 ELETLINEGSSLRIELQQLDLLQKRLKQCKWYKR-SQGLRETSSKLTYQDVKNLLHIAAADLDPT 1092
            |...::.||.||:::..:|...::.:::.:|... :|..::|.|  |.:::..|:.........:
pombe   929 ECLAIVEEGESLQLKTPELLYFKQYMEKTEWIDSFNQISQKTDS--TMEELVELIERGEKIGLTS 991

  Fly  1093 DPYVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHELGEIEQF-LKSASDINGQVPSHGLLKDA 1156
            |   ::.|.....:....|.|..|.    ..|..|..|...:.| ||  |:.|....:.|||
pombe   992 D---NENMATALLLKEKSENWMKQV----EGLLSQETLSTSKLFQLK--SEANSICINRGLL--- 1044

  Fly  1157 LRKAREWLRAVEQLQQNNHVTYCH--------------TLE---AMIERGLNIPIQLEELSRMQG 1204
                 |.|..|.|..:|.|.....              |:|   .::....|:..:.||.:..|.
pombe  1045 -----EQLNEVLQKSENFHTQLVSLISRARDPDYYSRPTIEEAKTVLAESENLTNKPEEYTVAQK 1104

  Fly  1205 HLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINIDSDLKPRFQDDFLKEKNPAEIV----- 1264
            .|...::|.......|   |.....||:.....               :|::::|...:|
pombe  1105 LLTQTYEWVRRGKRLF---GKANAPLEIFNQHL---------------EFVEQRNTNAMVDEGSD 1151

  Fly  1265 ASFKHAEEQELLDMRELRRQNMNKNPMRDMFCLCKSEFRNLMFNCQLCRDWFHEDCVPPPSATNQ 1329
            |.|....|..::         ...:|....:|.|:.....:|..|:||.:|:|..|:.......:
pombe  1152 APFHVGNEYYVI---------AGSDPSDFHYCFCRQPEAGMMIECELCHEWYHAKCMKMSKKKLR 1207

  Fly  1330 NGIVNGGSGPGTNRPKWLCPSC-VRSKRPRLETILPLLVQLQQ-------LPIRLPEDEALRCLA 1386
            ..            .|::||.| .|.:.|| .:..|.|::||:       ||.:..|.|.|:.:.
pombe  1208 AD------------EKFICPICDYRVEVPR-HSHRPPLIELQKMVDDIPTLPFQPIEIELLKRVV 1259

  Fly  1387 ERAMNWQDRARKALSSPDVSAAQEAIMAQQQQKRRSEGGAGVGNISSPRKPRRRGSLTKEASGST 1451
            ::|..::::.:..:..| ...:::.:...|...|:.||
pombe  1260 KQAEEFKNKMQSEVCDP-TQLSEKDVPLLQFYLRKLEG--------------------------- 1296

  Fly  1452 ESDADDDDDEDECRLRIVEDNFSNDEDEPRTAPATSTVNSDLLKLLSDSEIENLLDLMMEGDLLE 1516
                                                            |||     |..|.  |.
pombe  1297 ------------------------------------------------SEI-----LFTEE--LN 1306

  Fly  1517 VSLDETQELWRILETMPPTLLQAEAMERVVQYMQRQRQQHTNPLPTSGAEDSNDSLMVQNSPNSN 1581
            |...:..|...:....||.:              .:.:.:..|.||....:    :|.|......
pombe  1307 VFRQKLHEFMPVAPQPPPFI--------------GESRSNRKPRPTKRQRE----IMEQVESGKL 1353

  Fly  1582 SNSGGATGSASNSGRNKKRRSNDTGGNSAVPRKKQSTPKQTPGKKGSAAAARKSDAKASPAASTT 1646
            :::.||...|:...||:         |:.:.:........|.    .:..|.||.|:|:.:.:..
pombe  1354 TSAEGAAAIAATQTRNQ---------NNFISKPFNVHTLSTT----LSPWAMKSLAQAAISPNPM 1405

  Fly  1647 PGADADAENKQANGGNTNSSTGSGGGNSATTTPTPGSTHKKRKRTSTTATNNNNNNNNNSTNNSN 1711
            |.|                       :....|..|....                     ||.|.
pombe  1406 PSA-----------------------HDLLPTSNPAELF---------------------TNISP 1426

  Fly  1712 SSTNLNSNTTSGQGAATGGNNATGGQKKHAQRSQQAAQEDDEEECRAENCHKPTGREVDWVQCDG 1776
            ....|:.::||    ..||.|::     |....|.|:     ..|.   |.:|.......|||.
pombe  1427 EIKELSVDSTS----TLGGLNSS-----HLVSDQNAS-----VICL---CRQPFAISDGTVQCH- 1473

  Fly  1777 GCNEWFHMYCVGLNRSQIKPDDDYICIRCTKTVAIGTQGSGHSMSVASTTTP 1828
            .|.||||..||||:...:....:|.|..|     ...:|..:..:....:||
pombe  1474 NCLEWFHYECVGLSSDIVSTLSNYACPDC-----CSKEGKLYPWNTRPRSTP 1520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	13/35 (37%)
		ARID	227..312	CDD:198082	12/89 (13%)
		PHD1_Lid_like	450..495	CDD:277078	13/49 (27%)
		JmjC	624..740	CDD:202224	26/115 (23%)
		zf-C5HC2	830..882	CDD:280996	14/54 (26%)
		PLU-1	896..1229	CDD:285609	80/375 (21%)
		PHD2_KDM5A	1295..1351	CDD:277079	12/55 (22%)
		PHD3_KDM5A_like	1755..1805	CDD:277083	17/49 (35%)
msc1	NP_593431.1	JmjN	80..123	CDD:128818	13/35 (37%)
		PHD_SF	299..342	CDD:276966	12/46 (26%)
		JmjC	513..628	CDD:202224	28/122 (23%)
		zf-C5HC2	716..764	CDD:280996	14/51 (27%)
		PLU-1	780..1129	CDD:285609	81/379 (21%)
		PHD_Ecm5p_Lid2p_like	1173..1217	CDD:276993	12/55 (22%)
		PHD_SF	1457..1502	CDD:304600	17/48 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	195	1.000	Inparanoid score	I1022
OMA	1	1.010	-	-		QHG53001
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10694
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.060