Protein Alignment Kdm5 and lid2

DIOPT Version :10

• Sequence 1: NP_523486.1
• Gene: Kdm5 / 33837
• FlyBaseID: FBgn0031759
• Length: 1838
• Species: Drosophila melanogaster
• Sequence 2: NP_596174.1
• Gene: lid2 / 2541299
• PomBaseID: SPBP19A11.06
• Length: 1513
• Species: Schizosaccharomyces pombe
• Alignment Length: 1731
• Identity: 327/1731 - (18%)
• Similarity: 559/1731 - (32%)
• Gaps: 524/1731 - (30%)

  Fly   187 KCGIAKILPPATWSPPFAVDVDKLRFVPRVQRLNELEAKTRVKLNFLDQIAKFWELQGSSL-KIP 250
            |.|..|:|||..|..|..:|.....|..:.|.||:.........::..::..|.|.:|... ..|
pombe    82 KNGAIKLLPPEGWQIPVVLDQGAFEFQSKRQCLNKGCLNYEKNYDYFKKLKAFHESRGLYFYHPP 146

  Fly   251 MVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKVANRMQYPSSKSVGATLKAHYERILHPFEVYT 315
            ::..:.:|...|...:.:......:..:....||...::...:|.|...|...|:|.:.|||
pombe   147 IIGNRPVDFLRLRNAISKFTNSGSSLNNEILHKVIIYLRLEDTKEVRQVLTRCYDRYIKPFE--- 208

  Fly   316 SGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEIPTRQQIAPPNETNTRRSKRFGNSNASCGLSG 380
                         ..|:|         .:|:..          :|::||:.:   |:.:|.....
pombe   209 -------------RDSSP---------SFKSKR----------SESSTRKIR---NTRSSAQQES 238

  Fly   381 VTPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLAT----GTTANTRGASQKKGGEPPAL 441
            ..|.|                            |..||:.|    |:|:..|...::  ||.
pombe   239 PIPET----------------------------SAQSPVQTIQVNGSTSLKRPLIER--GEQ--- 270

  Fly   442 IVDPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVS--KPQ 504
                     |..|......|::||||||:.:|||.||.||||||||.:|.|..|.. .:|  .|:
pombe   271 ---------CEYCGLDKNPETILLCDGCEAAYHTSCLDPPLTSIPKEDWYCDACKF-NISDYDPR 325

  Fly   505 EAFGFEQAE-REYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVSSIDED------VTV 562
            :.|.::.:. :|.:.:.|..:.::....   |..:|...: :|..:|   ||:.|.      :.:
pombe   326 KGFKWKLSSLKERSAEIFNTLGERNSSS---KLTNLTEDD-IELFYW---SSLAESNSGFAPLEL 383

  Fly   563 EYGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMNAPWMYV 627
            |..:..:|....|..|:|....|    ::|:...|||:|||.....:..:..:|:|.:....:.:
pombe   384 EGLSQAYTSTIQSSLPSKEVFPL----EKYSSEPWNLHNLPFENPCLFNYSFSDLSSLTITRLSI 444

  Fly   628 GMCFAAFCWHNEDHWSYSINYLH---WGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLHQ 689
            ||.|....|...   |.|...||   :|:..|||.:|...::.||..:..:.|:......:..:.
pombe   445 GMVFYTHGWTKS---SLSTGLLHHHRFGDTVTWYVLPPDESDAFERYLISSYPQYTMEDLNRSNG 506

  Fly   690 LVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMG--REC 752
            |..|::|:.|:.|.......|....||::..|.:||.||:||::..|:||||..:|:|.|  ...
pombe   507 LPVIVSPSSLIENGFHPIAIDLRPNEFLVVSPNSYHMGFHQGFSSFESVNFATVNWIKDGLLNSS 571

  Fly   753 VNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYID------MAEMVDTEKKLRKSLLEWG 811
            ::....:|.....|::.::..|.|.        ...|:..      ..:|:..|...:..:::.
pombe   572 ISVLKSMRIPSSVSYEAVIISMVLS--------KNPCFSSEWLIKCFEDMIANESASKNEIMKL- 627

  Fly   812 VTRAERRAFELVNDDERHCQECNTTCFLSAVACECNDKLIVCLRHYTVLCGCAPE------KHTL 870
            |...:....|.....|..|..|...||||.:.|. ..|..:||.      .|..|      ...|
pombe   628 VPNIQALKLESSVPLEIRCSNCKQPCFLSFMQCH-EPKKFICLG------DCVKEVSLNATSWML 685

  Fly   871 IYRYTLDEMPLMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQELQELCKEAETKKF--PSSL 933
            .||:.:.|:..:.::........|.|.:|.|.::.  |.....|:.|:.|..:||....  |.::
pombe   686 FYRWDVHELSNLAERFVSLIRGPEEWTNRLRSVLS--TSPKPQLKVLKSLLVDAEKAMLTTPETV 748

  Fly   934 ----LIDRLNAAAVEAEKCVTVIQQLGINKVRTRS-------DH-------NQEAAQYKL--TME 978
                .:...|:......:|:.|   ..:.:.:.:.       ||       ...|..:|:  |..
pombe   749 NLRDFVQNANSWIDSVNECLKV---ASLKRKKDKKPPLFKAHDHWNNTSNLKDSAVLFKVLQTSR 810

  Fly   979 ELELFVQEIDNLCCIIDEGASVRELLVLGKQFVERSESQLQLSLESLEESELETLINEGSSLRIE 1043
            .:....|||:|:      .....:||....:.:.....       .|:::..:.|:.|...|...
pombe   811 SMAFTCQEIENM------KQKAFDLLEFRNRLINSFSG-------PLDKNTCQRLLTEAELLGFT 862

  Fly  1044 LQQLDLLQKRLKQCKWYKRSQGLRETSSKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQIGA 1108
            :.:|.::||.|.|.:|.........|  :.|..|::.|:....:...|.|   :..|...:.:..
pombe   863 IPELGIIQKYLIQFEWLDMFYSFETT--RTTDSDLERLITYGVSAGIPED---NDYMIFAKAMKG 922

  Fly  1109 DIEAWESQAAKYFRRLTQQHELGEIEQFLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQN 1173
            ..|.||:|                                    :.|.|.|
pombe   923 RAEIWENQ------------------------------------VYDTLSK-------------- 937

  Fly  1174 NHVTYCHTLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDN--TACAFLKKGTFYTLLEVLMPR 1236
            ::::| ..|..:.:..:|:.:..|..|::.|.||:|.:.|:.  |.|...::..|     .|.|.
pombe   938 SNISY-DKLSLLRDEAMNLCVNKELFSKVVGILNNAEEIKNKIATLCERSQEKDF-----ALRPS 996

  Fly  1237 SDAIN---IDSDLKPRFQDD---------------------FLKEKNPAEIVASFKHAEEQELLD 1277
            .|.:.   ..::..|...:.                     |.|...|.||:.  :|.:..|..:
pombe   997 IDEVKEALASAEKLPILSESTVTLQKMYDVVLEWIRRGKRLFGKANAPLEILG--QHLDYVEKRN 1059

  Fly  1278 MRELRRQNMNKNPMRD---------------------MFCLCKSEFRNLMFNCQLCRDWFHEDCV 1321
            ...|...:....||..                     :||.|:.....:|..|::|.:|:|..|:
pombe  1060 SASLSLNDRPGPPMEPASRETSPDSEGRLTIRKKKGCIFCFCRLPESGVMIECEICHEWYHAKCL 1124

  Fly  1322 PPPSATNQNGIVNGGSGPGTNRPKWLCPSC-------VRSKRPRLETILPLLVQLQQLPIRLPED 1379
            .......:..            .|:.||.|       ..|.||:||.:..|...::.||.:..|.
pombe  1125 KMSKKKLRQD------------EKFTCPICDYRVEIPRLSNRPKLEDLQSLYKDVKLLPFQPKET 1177

  Fly  1380 EALRCLAERAMNWQDRARKALSSPDVSAAQEAIMAQQQQKRRSEGGAGVGNISSPRKPRRRGSLT 1444
            |.||.:.:.|..::...:....:|                         ..::....|..|..|.
pombe  1178 ETLRKVVDLASKFRQEMQALAHNP-------------------------FGLTMAEVPLARFYLR 1217

  Fly  1445 KEASGSTESDADDDDDEDECRLRIVEDNFSNDEDEPRTAPATSTVNSDLLKLLSDSEIENLLDLM 1509
            |
pombe  1218 K---------------------------------------------------------------- 1218

  Fly  1510 MEG-DLLEVSLDET----QELWRILETMPPTLLQAEAMERVVQYMQRQRQQHTNPLPTSGAEDSN 1569
            ||| ::|.|  |||    |:|...:...|                        ||.|..|...|.
pombe  1219 MEGAEILLV--DETNLFRQKLHECVPIAP------------------------NPPPIIGESKST 1257

  Fly  1570 DSLMVQNSPNSNSNSGGATGSASNSGRNKKRRSNDTGGNSAVPRKKQSTPKQTPGKKGSAAAARK 1634
                                                       ||.:.|.:|....|..|.....
pombe  1258 -------------------------------------------RKPRPTKRQRQIMKQVAEGLLP 1279

  Fly  1635 SDAKASPAASTTPGADADAENKQANGGNTNSSTGSGGGNSATTTPTPGSTHKKRKRTSTTATNNN 1699
            :.|.|.|.:|.        |.|.:|            ...|....|...:.|..|:..|..::.|
pombe  1280 ASAIAPPKSSN--------EKKSSN------------NVKAVEAETKSKSEKSPKKNGTNISDAN 1324

  Fly  1700 NNNNNNSTNNSNSSTNLNSNTTSGQGAATGGNNATGGQKKHAQRSQQAAQEDDEEECRAENCHKP 1764
            |.|        .|..:|..|...|..|..                  ...::....|.......|
pombe  1325 NKN--------ESHVSLMKNWKLGSPAFV------------------TLVKEKNSSCLCGEEFSP 1363

  Fly  1765 TGREVDWVQCDGGCNEWFHMYCVGLNRSQIKPDDDYICIRC 1805
            ....:|...|:    ..||..|||||.........:.|..|
pombe  1364 RDSFIDCTICE----RRFHYDCVGLNNEIADSVSKFTCPIC 1400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm5	NP_523486.1	JmjN	160..201	CDD:128818	7/13 (54%)
		ARID_JARID	226..312	CDD:350628	14/86 (16%)
		PHD1_Lid_like	450..495	CDD:277078	24/44 (55%)
		JmjC	624..740	CDD:396791	33/118 (28%)
		zf-C5HC2	830..882	CDD:460750	16/57 (28%)
		PLU-1	896..1231	CDD:462475	61/358 (17%)
		PHD2_KDM5A	1295..1351	CDD:277079	12/55 (22%)
		PHD3_KDM5A_like	1755..1805	CDD:277083	12/49 (24%)
lid2	NP_596174.1	ARID	122..208	CDD:198082	14/85 (16%)
		PHD1_Lid2p_like	270..315	CDD:276994	24/56 (43%)
		cupin_RmlC-like	441..557	CDD:477354	33/118 (28%)
		zf-C5HC2	646..697	CDD:460750	16/57 (28%)
		PLU-1	710..1049	CDD:462475	70/417 (17%)
		PHD_Ecm5p_Lid2p_like	1098..1142	CDD:276993	12/55 (22%)
		PHD3_Lid2p_like	1354..1400	CDD:276995	12/49 (24%)