DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and jmj3

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_595639.1	Gene:	jmj3 / 2540780	PomBaseID:	SPBC83.07	Length:	752	Species:	Schizosaccharomyces pombe

Alignment Length:	717	Identity:	147/717 - (20%)
Similarity:	231/717 - (32%)	Gaps:	226/717 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   544 MVER--EFWRIVSSIDEDVTVEYGADLHTMDHGSGFPTKSSLYLLPGDQEY-------AESSWNL 599
            ||.|  |::.|.|.|               ||||..|.|      |.|...       |.||.:.
pombe    95 MVRRKGEYFEIQSDI---------------DHGSAGPKK------PTDMNVDDRFPSNAGSSNDF 138

  Fly   600 NN----------LPLLEDSI-LGHINAD------ISGMNA---------------PWMYVGMCFA 632
            .|          ..|..||: .|:.|..      |..::|               .|..||..||
pombe   139 ENNVAKAIAYYWRSLTHDSLWYGYTNRPSIPFYFIPSISAAQKDRVHLRSNTLINTWPNVGHLFA 203

  Fly   633 AFCWHNEDHWSYSINYLH------WGEPKTWYGVPGSCAEQFEETM-KQAAPELFSSQPDLLHQL 690
            . .|.....|......||      .|....||.:|.:.:|.|::.. |.|..|.:.....||||.
pombe   204 G-KWKTTLPWRVESPELHAVQVHLGGSSLQWYVIPSAHSESFKKLAGKLAQDEHWRCSDFLLHQN 267

  Fly   691 VTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQG-----------------YNFAEAV 738
            : :..|:.|:.|.:..:.|.....|.:||||..:|:.|..|                 |.|:...
pombe   268 I-LFPPSTLVQNGIVTYSTVLKQDELLITFPGTHHSAFCLGDAVLRRFVFRSPRSASNYEFSNLR 331

  Fly   739 NFAPADWLKMGRECVNHYSMLRRFC----------------------------------VFSHDE 769
            ....::.|...:....|....:|.|                                  .||..:
pombe   332 RLMVSESLYSSKSLWPHSHKPQRACSQKFLDEFYLHDLPESNIHDSGNFHPIHSSVDNNSFSQRD 396

  Fly   770 LVCKMALE-PAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAERR-AFELV-NDDERHCQ 831
            .....::. |:.|.....:|..........|||:|  |.|..|..|..|. ...|: |...|  :
pombe   397 FDSPNSINPPSPLMSNHESASTEHFNSTTTTEKEL--SSLHVGEERKNRSLPLSLIWNSKAR--E 457

  Fly   832 ECNTTCFLSAVACECNDKLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMPLMLQKLKVKAHSFERW 896
            |     ::.....|..|.  :...|:..|. ..|..|      .|...|::...:..:....|.:
pombe   458 E-----YIKKQKEENGDN--IEFSHFDPLY-TRPSSH------PLHPPPILGLPVPAQFARGELF 508

  Fly   897 LSR-CRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLIDRLNAA----------AVEAE---- 946
            |.| ..|.|..|    :.|.|    |::::..:.|...::...:||          |::|.
pombe   509 LGRILEDRVSEH----MLLLE----CEKSDVVEVPYECILTSSSAAGRRESSYYNPALKAPNIVY 565

  Fly   947 ----------------------------KCVTVIQQLGINKVRTRSDHNQEAAQYKLTMEELELF 983
                                        |.:.....:.:.....::...:|:::...:::.....
pombe   566 DDGVPINWNEYSELPSLDRFVLPKLLPGKPIEFTPPISVEPTSIKTIAAEESSEPTSSVDVAPTP 630

  Fly   984 VQEID-NLCCIIDEGASVREL---LVL--GKQFVERSESQLQLSLESLEESELET--LINEGSSL 1040
            |:::: ||..|.:...||.:|   ||.  |.:.||||      |:..|||..|||  .|.|.|.:
pombe   631 VEDVNVNLESISNTNESVVDLSDPLVSKNGFEDVERS------SVADLEEDVLETRSSIFETSDI 689

  Fly  1041 RIELQQLDLLQKRLKQCKWYKRSQGLRETSSKLTYQDVKNLLHIAAAD----LDPTDPYVDKEMR 1101
            ...|..:|             |||.:..:.|:.:.... ||....|.|    ||..:.||..|:.
pombe   690 DDRLTVID-------------RSQSVVPSESEFSIAGA-NLTRRNAVDFSVSLDTYELYVSDEVE 740

  Fly  1102 KL 1103
            .:
pombe   741 NV 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818
		ARID	227..312	CDD:198082
		PHD1_Lid_like	450..495	CDD:277078
		JmjC	624..740	CDD:202224	36/139 (26%)
		zf-C5HC2	830..882	CDD:280996	9/51 (18%)
		PLU-1	896..1229	CDD:285609	54/263 (21%)
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
jmj3	NP_595639.1	JmjN	33..74	CDD:128818
jmj3	NP_595639.1	JmjC	200..316	CDD:202224	31/117 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910