DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lid and Kdm4d

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_775609.2	Gene:	Kdm4d / 244694	MGIID:	3606484	Length:	510	Species:	Mus musculus

Alignment Length:	494	Identity:	134/494 - (27%)
Similarity:	200/494 - (40%)	Gaps:	137/494 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 TPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALIVDPL 446
            |....|:..:.:...|||||     :.|:
Mouse     6 TCAQNPNCSIMIFRPTKEEF-----NDFD------------------------------------ 29

  Fly   447 MKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEW------------LCPRCVVEE 499
             |||.::.::|.....:                  ...||..||            |....:.:.
Mouse    30 -KYIAYMESQGAHRAGL------------------AKVIPPKEWRARQSYDNISNILIATPLQQV 75

  Fly   500 VSKPQEAF-GFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFW--RIVSSIDEDVT 561
            ||.....| .:.:.::..|:.::.::|:..|   ::.|.|| ..|.:||::|  |:..|
Mouse    76 VSGQAGVFTQYHKKKKGMTVGEYRELANSKK---YQTPPHL-DFEDLERKYWKNRLYES------ 130

  Fly   562 VEYGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMNAPWMY 626
            ..||||:    .||.|..|:             ..||:.:|..::|.:.......|.|:|.|::|
Mouse   131 PIYGADV----SGSLFDGKT-------------QQWNVGHLGTIQDLLEQECGIVIEGVNTPYLY 178

  Fly   627 VGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELF--SSQ--PDLL 687
            .||....|.||.||...|||||||:|:|||||.||.....:.|    :.|.|||  |||  ...|
Mouse   179 FGMWKTTFAWHTEDMDLYSINYLHFGQPKTWYAVPPEHGRRLE----RLARELFPGSSQGCQAFL 239

  Fly   688 HQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGR-- 750
            ...|.:::|.:|..|.:|..|..|.||||::|||..||||||.|:|.|||:|||...|:..|:
Mouse   240 RHKVALISPTVLKENGIPFGRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKVA 304

  Fly   751 -ECVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAE-MVDTEKKL---------R 804
             :|    |.......||.|..|..:..|..:|.........:|..| ||.|.::|         |
Mouse   305 SQC----SCGEARVSFSMDAFVRILQPERYELWKRGQDQAVVDHTETMVSTSQELTTRRVTKAPR 365

  Fly   805 KSLLEWGVTRAERR-------AFELVNDDERHCQECNTT 836
            |:   ||:.|...|       ....|::...:.|.|:|:
Mouse   366 KT---WGLKRLRLRQVSRSLLPIATVSNVPCNMQVCHTS 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818
		ARID	227..312	CDD:198082
		PHD1_Lid_like	450..495	CDD:277078	7/56 (13%)
		JmjC	624..740	CDD:202224	57/119 (48%)
		zf-C5HC2	830..882	CDD:280996	3/7 (43%)
		PLU-1	896..1229	CDD:285609
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
Kdm4d	NP_775609.2	JmjN	15..55	CDD:128818	13/99 (13%)
		JmjC	176..292	CDD:334913	57/119 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..510		2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841793
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840