DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kdm5 and KDM6B

DIOPT Version :10

Sequence 1:NP_523486.1 Gene:Kdm5 / 33837 FlyBaseID:FBgn0031759 Length:1838 Species:Drosophila melanogaster
Sequence 2:NP_001073893.1 Gene:KDM6B / 23135 HGNCID:29012 Length:1682 Species:Homo sapiens


Alignment Length:1065 Identity:195/1065 - (18%)
Similarity:312/1065 - (29%) Gaps:393/1065 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 SANGTATPARRLRTRNSTGNGTNSGSESVKKSNANDEPSTPVTPAGATGSHTHAPPGISPAVMER 95
            :|..|..||..:.|..:|...|.:..|..||    ..|:.|..|..|     ..||...|    :
Human   740 TAPTTTAPAVAVTTTTTTTTTTTATQEEEKK----PPPALPPPPPLA-----KFPPPSQP----Q 791

  Fly    96 PMPSVPMNHAS-----SSVSASKKYHNSC-----------PHPTPT-------PA------PTGH 131
            |.|..|.:.||     :||...:||   |           |.|.||       |:      ||..
Human   792 PPPPPPPSPASLLKSLASVLEGQKY---CYRGTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSA 853

  Fly   132 KKSVHTQPH----SSNKF---------DQGKNEE----FHFDTPPECPVFRPTTEEFKNPLAYIS 179
            ..|....|.    ||::|         ::...||    ....|.|..|:..|........|..||
Human   854 APSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPPPLSLPPARSESEVLEEIS 918

  Fly   180 K-IRSIAEKCGIAKILP--PATWSPPFAVDVDKLRFVPRVQRLNEL--------EAKTRVKLN-- 231
            : ..::.|:.|.:...|  |...:.|  .|....|.:|..|...|.        ..|.|.|.:  
Human   919 RACETLVERVGRSATDPADPVDTAEP--ADSGTERLLPPAQAKEEAGGVAAVSGSCKRRQKEHQK 981

  Fly   232 --------FLDQI--------AKFWELQGSSLKIPMVERKA----LDLYTLHRIVQEEGGMEQTT 276
                    ..|.:        ||      :..|:|..:.:.    |||.:     :|..|.|::.
Human   982 EHRRHRRACKDSVGRRPREGRAK------AKAKVPKEKSRRVLGNLDLQS-----EEIQGREKSR 1035

  Fly   277 KDRKWAKVANRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGG 341
            .|...|..|.....|:..|..|....                   |||.|:.......:.|..|.
Human  1036 PDLGGASKAKPPTAPAPPSAPAPSAQ-------------------PTPPSASVPGKKAREEAPGP 1081

  Fly   342 TDYKAHEIPTRQQIA--PPNETNTR-------------------RSKRFGNSNASCGLSGVTPTT 385
            ......::...:.::  ||.|...|                   |..|..:...|...:.|...:
Human  1082 PGVSRADMLKLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVVRAS 1146

  Fly   386 KPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALIVDPLMKYI 450
            :       ..:.|.:|:...||...:|.         ...||.....::...||...:       
Human  1147 R-------NAKVKGKFRESYLSPAQSVK---------PKINTEEKLPREKLNPPTPSI------- 1188

  Fly   451 CHICNRGDVEESMLLCDGCDDSYHTFCLLP--PLTSI---------------------PKGEWLC 492
             ::.::.|....:||         .||..|  |:|.|                     ..||...
Human  1189 -YLESKRDAFSPVLL---------QFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTV 1243

  Fly   493 PRCVVEEVSKP----------QEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVER 547
            .  |..:|.:|          ::.:..|.:....|:.::.|......||..::          |:
Human  1244 E--VRTQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQE----------EK 1296

  Fly   548 EFWRIVSSIDE-----DVT----------------VEYGADLHTMDHGSGFPTKSSLYLLPGDQE 591
            |      |.||     |.|                :::|.::...|.....|....|..||....
Human  1297 E------SEDEESEEPDSTTGTPPSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMR 1355

  Fly   592 YAESSWNLNNLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKT 656
            ...:.           ::|.|:...|.|||...:|:.:..:....|.|::...|:| ::.|    
Human  1356 VTSTG-----------NMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVN-INIG---- 1404

  Fly   657 WYGVPGSCA-----EQFEETM-----KQAAPELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQ 711
                ||.|.     |.:.||:     :.....|..|...:|..|..         :.:||:|..|
Human  1405 ----PGDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYA---------SNIPVYRFVQ 1456

  Fly   712 HAGEFVITFPRAYH----------AGFNQG--------------------------------YNF 734
            ..|:.|.......|          ..:|.|                                :|.
Human  1457 RPGDLVWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNV 1521

  Fly   735 AEAVNFAPADWLKMGRECVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDT 799
            |..|..:..|..||           .:||:           |:..|       .|.:....:|..
Human  1522 ARTVKISDPDLFKM-----------IKFCL-----------LQSMK-------HCQVQRESLVRA 1557

  Fly   800 EKKLRKSLLEWGVTRAERRAFE-LVNDDER-HCQECNTTCF-LSAVACECNDKLIVCLRHYTVLC 861
            .||:               |:: .|.|:.. :|.||:...| :..|..|...:     ..|.|.|
Human  1558 GKKI---------------AYQGRVKDEPAYYCNECDVEVFNILFVTSENGSR-----NTYLVHC 1602

  Fly   862 -GCAPEKH------TLIYRYTLDEM 879
             |||..:.      .::.:|..:|:
Human  1603 EGCARRRSAGLQGVVVLEQYRTEEL 1627

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kdm5NP_523486.1 JmjN 160..201 CDD:128818 9/43 (21%)
ARID_JARID 226..312 CDD:350628 19/107 (18%)
PHD1_Lid_like 450..495 CDD:277078 11/67 (16%)
JmjC 624..740 CDD:396791 28/167 (17%)
zf-C5HC2 830..882 CDD:460750 14/58 (24%)
PLU-1 896..1231 CDD:462475
PHD2_KDM5A 1295..1351 CDD:277079
PHD3_KDM5A_like 1755..1805 CDD:277083
KDM6BNP_001073893.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 52..88
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 190..680
PRK12323 <572..718 CDD:481241
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 704..807 22/79 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 822..1096 57/305 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1325 9/52 (17%)
JmjC 1343..1407 CDD:214721 16/83 (19%)
JmjC 1377..1485 CDD:396791 23/125 (18%)
Blue background indicates that the domain is not in the aligned region.

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