DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and KDM6B

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_001073893.1	Gene:	KDM6B / 23135	HGNCID:	29012	Length:	1682	Species:	Homo sapiens

Alignment Length:	1060	Identity:	194/1060 - (18%)
Similarity:	313/1060 - (29%)	Gaps:	383/1060 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SANGTATPARRLRTRNSTGNGTNSGSESVKKSNANDEPSTPVTPAGATGSHTHAPPGISPAVMER 95
            :|..|..||..:.|..:|...|.:..|..||    ..|:.|..|..|     ..||...|    :
Human   740 TAPTTTAPAVAVTTTTTTTTTTTATQEEEKK----PPPALPPPPPLA-----KFPPPSQP----Q 791

  Fly    96 PMPSVPMNHAS-----SSVSASKKYHNSC-----------PHPTPT-------PA------PTGH 131
            |.|..|.:.||     :||...:||   |           |.|.||       |:      ||..
Human   792 PPPPPPPSPASLLKSLASVLEGQKY---CYRGTGAAVSTRPGPLPTTQYSPGPPSGATALPPTSA 853

  Fly   132 KKSVHTQPH----SSNKF---------DQGKNEE----FHFDTPPECPVFRPTTEEFKNPLAYIS 179
            ..|....|.    ||::|         ::...||    ....|.|..|:..|........|..||
Human   854 APSAQGSPQPSASSSSQFSTSGGPWARERRAGEEPVPGPMTPTQPPPPLSLPPARSESEVLEEIS 918

  Fly   180 K-IRSIAEKCGIAKILP--PATWSPPFAVDVDKLRFVPRVQRLNEL--------EAKTRVKLN-- 231
            : ..::.|:.|.:...|  |...:.|  .|....|.:|..|...|.        ..|.|.|.:
Human   919 RACETLVERVGRSATDPADPVDTAEP--ADSGTERLLPPAQAKEEAGGVAAVSGSCKRRQKEHQK 981

  Fly   232 --------FLDQIAKFWELQG---SSLKIPMVERKA----LDLYTLHRIVQEEGGMEQTTKDRKW 281
                    ..|.:.: ...:|   :..|:|..:.:.    |||.:     :|..|.|::..|...
Human   982 EHRRHRRACKDSVGR-RPREGRAKAKAKVPKEKSRRVLGNLDLQS-----EEIQGREKSRPDLGG 1040

  Fly   282 AKVANRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKA 346
            |..|.....|:..|..|....                   |||.|:.......:.|..|......
Human  1041 ASKAKPPTAPAPPSAPAPSAQ-------------------PTPPSASVPGKKAREEAPGPPGVSR 1086

  Fly   347 HEIPTRQQIA--PPNETNTR-------------------RSKRFGNSNASCGLSGVTPTTKPSAG 390
            .::...:.::  ||.|...|                   |..|..:...|...:.|...::
Human  1087 ADMLKLRSLSEGPPKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVVRASR---- 1147

  Fly   391 VFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALIVDPLMKYICHICN 455
               ..:.|.:|:...||...:|.         ...||.....::...||...:        ::.:
Human  1148 ---NAKVKGKFRESYLSPAQSVK---------PKINTEEKLPREKLNPPTPSI--------YLES 1192

  Fly   456 RGDVEESMLLCDGCDDSYHTFCLLP--PLTSI---------------------PKGEWLCPRCVV 497
            :.|....:||         .||..|  |:|.|                     ..||....  |.
Human  1193 KRDAFSPVLL---------QFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVE--VR 1246

  Fly   498 EEVSKP----------QEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRI 552
            .:|.:|          ::.:..|.:....|:.::.|......||..::          |:|
Human  1247 TQVQQPSDENWDLTGTRQIWPCESSRSHTTIAKYAQYQASSFQESLQE----------EKE---- 1297

  Fly   553 VSSIDE-----DVT----------------VEYGADLHTMDHGSGFPTKSSLYLLPGDQEYAESS 596
              |.||     |.|                :::|.::...|.....|....|..||.......:.
Human  1298 --SEDEESEEPDSTTGTPPSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTG 1360

  Fly   597 WNLNNLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVP 661
                       ::|.|:...|.|||...:|:.:..:....|.|::...|:| ::.|        |
Human  1361 -----------NMLSHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVN-INIG--------P 1405

  Fly   662 GSCA-----EQFEETM-----KQAAPELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEF 716
            |.|.     |.:.||:     :.....|..|...:|..|..         :.:||:|..|..|:.
Human  1406 GDCEWFAVHEHYWETISAFCDRHGVDYLTGSWWPILDDLYA---------SNIPVYRFVQRPGDL 1461

  Fly   717 VITFPRAYH----------AGFNQG--------------------------------YNFAEAVN 739
            |.......|          ..:|.|                                :|.|..|.
Human  1462 VWINAGTVHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVK 1526

  Fly   740 FAPADWLKMGRECVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLR 804
            .:..|..||           .:||:           |:..|       .|.:....:|...||:
Human  1527 ISDPDLFKM-----------IKFCL-----------LQSMK-------HCQVQRESLVRAGKKI- 1561

  Fly   805 KSLLEWGVTRAERRAFE-LVNDDER-HCQECNTTCF-LSAVACECNDKLIVCLRHYTVLC-GCAP 865
                          |:: .|.|:.. :|.||:...| :..|..|...:     ..|.|.| |||.
Human  1562 --------------AYQGRVKDEPAYYCNECDVEVFNILFVTSENGSR-----NTYLVHCEGCAR 1607

  Fly   866 EKH------TLIYRYTLDEM 879
            .:.      .::.:|..:|:
Human  1608 RRSAGLQGVVVLEQYRTEEL 1627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	9/43 (21%)
		ARID	227..312	CDD:198082	18/101 (18%)
		PHD1_Lid_like	450..495	CDD:277078	11/67 (16%)
		JmjC	624..740	CDD:202224	28/167 (17%)
		zf-C5HC2	830..882	CDD:280996	14/58 (24%)
		PLU-1	896..1229	CDD:285609
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
KDM6B	NP_001073893.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..88
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..680
		Mito_fiss_reg	<566..640	CDD:283069
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..807		22/79 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..1096		56/300 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1325		9/52 (17%)
		JmjC	1343..1407	CDD:214721	16/83 (19%)
		JmjC	1377..1485	CDD:202224	23/125 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900