DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and Kdm4a

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_001155295.1	Gene:	Kdm4a / 230674	MGIID:	2446210	Length:	1064	Species:	Mus musculus

Alignment Length:	1274	Identity:	252/1274 - (19%)
Similarity:	419/1274 - (32%)	Gaps:	431/1274 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 LSGVTPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALI 442
            ::..:.|..|||.:.....|.|||:.
Mouse     1 MASESETLNPSARIMTFYPTMEEFRN--------------------------------------- 26

  Fly   443 VDPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSK----- 502
               ..:||.:|.::|.....:                  ...:|..||. ||...:::..
Mouse    27 ---FSRYIAYIESQGAHRAGL------------------AKVVPPKEWK-PRTSYDDIDDLVIPA 69

  Fly   503 --PQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPT----EMVEREFWRIVSSIDEDVT 561
              .|...|......:|.:|:......:|: :......:..|.    |.:||::|:       ::|
Mouse    70 PIQQLVTGQSGLFTQYNIQKKAMTVREFR-KIANSDKYCTPRYSEFEELERKYWK-------NLT 126

  Fly   562 VE---YGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMNAP 623
            ..   ||||::           .:||      |.....||:..|..:.|.:.......|.|:|.|
Mouse   127 FNPPIYGADVN-----------GTLY------EQHVDEWNIGRLKTILDLVEKESGITIEGVNTP 174

  Fly   624 WMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLH 688
            ::|.||...:|.||.||...|||||||:||||:||.||....::.|...|...|....|....|.
Mouse   175 YLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLR 239

  Fly   689 QLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECV 753
            ..:|:::|.:|....:|..:..|.||||:||||..||||||.|:|.||:.|||...|::.|::.|
Mouse   240 HKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAV 304

  Fly   754 --------NHYSM---LRRF--------------CVFSHDELVCKMALEPAKLTFGI-----ATA 788
                    ...||   :|||              .|..| .|....|.|..|.:.|:     :..
Mouse   305 LCSCRKDMVKISMDVFVRRFQPERYKLWKAGKDSMVIDH-TLPTPEAAEFLKDSGGLTPRAGSEE 368

  Fly   789 CYIDMAEMVD--TEKKLRKSLLEWGV-TRAERRAFEL---VNDDERHCQECNTTCFLSAVACECN 847
            |..:..|..|  .|..:::||.:..: |:..|...|:   |:..|
Mouse   369 CPEEDVEAADQGEEGDVKRSLAKHRIGTKRHRVCLEIPQEVSQSE-------------------- 413

  Fly   848 DKLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMPLMLQKLKVKAHSFERWLSRCRDIVDAHTPTSV 912
                           ..|::.....:|.:.|.|..|..:: ..||..|.:.......|...||.|
Mouse   414 ---------------LFPKEELSSGQYEMTECPATLAPVR-PTHSSVRQVEDSLPFPDYSDPTEV 462

  Fly   913 TLQELQEL-CKEAETKKFPSSLLID-RLNAAAVEAEKCVTVIQQLGINKVRTRSDHNQEAAQYKL 975
            ..:||:.: .:|.:.:..|.:..:| .:|.|:|......:..::...:.:.:.|..:..::..:
Mouse   463 KFEELKNVKLEEEDEEDEPEAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSTSSQDSVSSDSE- 526

  Fly   976 TMEELELFVQEIDNLCCII-----DEGASVRELLVLGKQFVERSESQLQLS------LESLEESE 1029
            |.|.:....||...:..:.     |..|:..|..|..|:...||.|:.:|:      :.||||:
Mouse   527 TAESVSCQGQEKTGVLTVHSYARGDGKAATGEPSVKKKRSAPRSISEQELAEVADEYMLSLEEN- 590

  Fly  1030 LETLINEGSSLRIELQQLDLLQKRLKQCKWYKRSQGLRETSSKLTYQDVKNLLHIAAADLDPTDP 1094
                                           |:::|.|:..|||...                .|
Mouse   591 -------------------------------KKTKGRRQPLSKLPRH----------------HP 608

  Fly  1095 YVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHELGEIEQFLKSASDINGQVPSHGLLKDALRK 1159
            .|      ||:.|:|.|..|        :||.:.|..|.|
Mouse   609 LV------LQECGSDDETSE--------QLTPEEEAEETE------------------------- 634

  Fly  1160 AREWLRAVEQLQQNNHVTYCHTLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDNTACAFLKKG 1224
              .|.:.:.||.||....:    ||  |:..|     |.:::...|            ||...
Mouse   635 --AWAKPLSQLWQNRPPNF----EA--EKEFN-----EIMAQQAPH------------CAVCM-- 672

  Fly  1225 TFYTLLEVLMPRSDAINIDSDLKPRFQDDFLKEKNPAEIVASFKHAEEQELLDMRELRRQNMNKN 1289
            .|.|..:|                    :|              .|..|...|..|...|.....
Mouse   673 IFQTYHQV--------------------EF--------------GAFSQSCGDASEPAAQTQRTK 703

  Fly  1290 PMRDMFCL----CKSEFR-----------NLMFNCQLCRDWFHEDC--VPPPSATNQ-------- 1329
            |:....|.    |.::..           :::.:|:.|....|..|  |||..|:.:
Mouse   704 PLIPEMCFTTTGCSTDINLSTPYLEEDGTSMLVSCKKCSVRVHASCYGVPPAKASEEWMCSRCSA 768

  Fly  1330 NGI--------VNGGSGPGTNRPKWLCPSC-----------VRSKRPRLETILPLLVQLQQLPIR 1375
            |.:        :.||:....|..:|:..||           :..:.|         |.:.::|:.
Mouse   769 NALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSP---------VDVSKIPLP 824

  Fly  1376 LPEDEALRCLAERAMN----WQDRARKALSSPDVSAAQEA-IMAQQQQ----------KRRSEGG 1425
            ..:.:.:.|...|..|    .|....:..::..||.||.| :|.|...          :.:
Mouse   825 RFKLKCVFCKKRRKRNAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHK---- 885

  Fly  1426 AGVGNISSPRKPRRRGSLTKEASGSTESDADDDDDEDECRL------RIVEDNFSNDEDEPRTAP 1484
                   .|...|.:|:|....:|........:....:|.:      ...|.||.:........|
Mouse   886 -------IPNLERAKGALLSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYP 943

  Fly  1485 ATSTVNSDLLKLLSDSEIENLLDLMMEGDLLEVSLDETQ 1523
             ...|:.|.|:|...:          ||::::|...:.|
Mouse   944 -EDIVSQDCLQLGPPA----------EGEVVQVRWTDGQ 971

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818
		ARID	227..312	CDD:198082
		PHD1_Lid_like	450..495	CDD:277078	7/44 (16%)
		JmjC	624..740	CDD:202224	51/115 (44%)
		zf-C5HC2	830..882	CDD:280996	4/51 (8%)
		PLU-1	896..1229	CDD:285609	63/345 (18%)
		PHD2_KDM5A	1295..1351	CDD:277079	15/88 (17%)
		PHD3_KDM5A_like	1755..1805	CDD:277083
Kdm4a	NP_001155295.1	JmjN	13..55	CDD:128818	11/102 (11%)
		JmjC	175..291	CDD:334913	51/115 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..384		6/29 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..489		13/55 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..537		3/35 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..573		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	590..643		20/141 (14%)
		Interaction with NCOR1. /evidence=ECO:0000250	597..638		18/97 (19%)
		PHD_SF	667..766	CDD:389947	23/146 (16%)
		ePHD_JMJD2A	775..884	CDD:277183	20/117 (17%)
		Tudor_2	902..936	CDD:375553	5/33 (15%)
		Tudor_2	960..994	CDD:375553	3/12 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841789
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840