DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and KDM4B

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	XP_005259578.2	Gene:	KDM4B / 23030	HGNCID:	29136	Length:	1130	Species:	Homo sapiens

Alignment Length:	473	Identity:	125/473 - (26%)
Similarity:	182/473 - (38%)	Gaps:	127/473 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 SKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTTANTRGA 430
            |:..|..|.||.:....|             |.||||     .||
Human     3 SEDHGAQNPSCKIMTFRP-------------TMEEFK-----DFN-------------------- 29

  Fly   431 SQKKGGEPPALIVDPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRC 495
                             ||:.:|.::|.....:                  ...||..||. ||.
Human    30 -----------------KYVAYIESQGAHRAGL------------------AKIIPPKEWK-PRQ 58

  Fly   496 VVEEVSK-------PQEAFGFEQAEREYTLQQFGQMADQFKQ----EYFRKPVHLVPTEMVEREF 549
            ..:::..       .|...|......:|.:|:......::::    |.:..|.| ...:.:||::
Human    59 TYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRH-QDFDDLERKY 122

  Fly   550 WR---IVSSIDEDVTVEYGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNLNNLPLLEDSILG 611
            |:   .||.|       ||||:      ||     |||    |.:.|:  ||:.:|..:.|.:..
Human   123 WKNLTFVSPI-------YGADI------SG-----SLY----DDDVAQ--WNIGSLRTILDMVER 163

  Fly   612 HINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAA 676
            .....|.|:|.|::|.||....|.||.||...|||||||:||||:||.:|....::.|.......
Human   164 ECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFF 228

  Fly   677 PELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFA 741
            |.........|...:|:::|.||....:|..|..|.||||:||||..||||||.|:|.||:.|||
Human   229 PGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFA 293

  Fly   742 PADWLKMGR---ECVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKL 803
            ...|:..|:   :|.....|::    .|.|..|  ..|:|.:........   |:..:..|....
Human   294 TLRWIDYGKVATQCTCRKDMVK----ISMDVFV--RILQPERYELWKQGK---DLTVLDHTRPTA 349

  Fly   804 RKS--LLEWGVTRAERRA 819
            ..|  |..|..:||..:|
Human   350 LTSPELSSWSASRASLKA 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818
		ARID	227..312	CDD:198082
		PHD1_Lid_like	450..495	CDD:277078	7/44 (16%)
		JmjC	624..740	CDD:202224	50/115 (43%)
		zf-C5HC2	830..882	CDD:280996
		PLU-1	896..1229	CDD:285609
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
KDM4B	XP_005259578.2	JmjN	15..56	CDD:128818	16/114 (14%)
		JmjC	176..292	CDD:202224	50/115 (43%)
		PHD_JMJD2B	717..822	CDD:277051
		ePHD_JMJD2B	831..940	CDD:277184
		TUDOR	955..1007	CDD:197660
		TUDOR	1009..1064	CDD:197660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151684
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840