Protein Alignment Kdm5 and Kdm6b

DIOPT Version :10

• Sequence 1: NP_523486.1
• Gene: Kdm5 / 33837
• FlyBaseID: FBgn0031759
• Length: 1838
• Species: Drosophila melanogaster
• Sequence 2: XP_030101676.1
• Gene: Kdm6b / 216850
• MGIID: 2448492
• Length: 1642
• Species: Mus musculus
• Alignment Length: 1042
• Identity: 179/1042 - (17%)
• Similarity: 297/1042 - (28%)
• Gaps: 413/1042 - (39%)

  Fly    36 ATPARRLRTRNSTGNGTN---SGSESVKKSNANDEPSTPVTPAGATGSHTHAPPGISPAVMERPM 97
            |:||..|::..|...|..   .|:.:...:.....|:|..:|:.|:|:....|..::|:....|.
Mouse   800 ASPASLLKSLASVLEGQKYCYRGTGAAVSTRPGSVPATQYSPSPASGATAPPPTSVAPSAQGSPK 864

  Fly    98 PSVPMNHASSSVSAS----KKYHNSCPHPTP---TPAPTGHKKSVHTQPHSSNKFDQGKNEEFHF 155
            |||   .:||..|.|    .:.|.:...|.|   |||
Mouse   865 PSV---SSSSQFSTSGGPWAREHRAGEEPAPGPVTPA---------------------------- 898

  Fly   156 DTPPECPVFRPTTEEFKNPLAYISK-IRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRL 219
            ..||..|:  |........|..||: ..::.|:.|.:.|.|..|..|     ||
Mouse   899 QLPPPLPL--PPARSESEVLEEISRACETLVERVGRSAINPVDTADP-----VD----------- 945

  Fly   220 NELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTT----KDRK 280
                                   .|:..:.|..:.|           :|.||:....    ..::
Mouse   946 -----------------------SGTEPQPPPAQAK-----------EESGGVAVAAAGPGSGKR 976

  Fly   281 WAKVANRMQYPSSKSVG---------ATLKAHYERILHPFEVYTSGKVLGPTPTSSG--SGSTPV 334
            ..|...|.:.....|||         |..||..|:         |.:|||.....|.  .|....
Mouse   977 RQKEHRRHRRACRDSVGRRPREGRAKAKAKAPKEK---------SRRVLGNLDLQSEEIQGREKA 1032

  Fly   335 KLEDGGGTDYKAHEIP-----------------------TRQQI-------------------AP 357
            :.:.||.:..|....|                       ||::.                   .|
Mouse  1033 RPDVGGVSKVKTPTAPAPPPAPAPAAQPTPPSAPVPGKKTREEAPGPPGVSRADMLKLRSLSEGP 1097

  Fly   358 PNETNTR-------------------RSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEFKR 403
            |.|...|                   |..|..:...|...:.|...:|       ..:.|.:|:.
Mouse  1098 PKELKIRLIKVESGDKETFIASEVEERRLRMADLTISHCAADVMRASK-------NAKVKGKFRE 1155

  Fly   404 DLLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALIVDPLMKYICHICNRGDVEESMLLCDG 468
            ..||...:|.         ...||.....::...||...:        ::.::.|....:||
Mouse  1156 SYLSPAQSVK---------PKINTEEKLPREKLNPPTPSI--------YLESKRDAFSPVLL--- 1200

  Fly   469 CDDSYHTFCLLP--PLTSI---------------------PKGEWLCPRCVVEEVSKP------- 503
                  .||..|  |:|.|                     ..||....  |..:|.:|
Mouse  1201 ------QFCTDPRNPITVIRGLAGSLRLNLGLFSTKTLVEASGEHTVE--VRTQVQQPSDENWDL 1257

  Fly   504 ---QEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVSSIDEDVT---- 561
               ::.:..|.:....|:.::.    |::...|::.:.....|..:.|      |.:.|.|
Mouse  1258 TGTRQIWPCESSRSHTTIAKYA----QYQASSFQESLQQEERESEDEE------SEEPDSTTGTS 1312

  Fly   562 ------------VEYGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHIN 614
                        :::|.::...|.....|....|..||.......:.           ::|.|:.
Mouse  1313 PSSAPDPKNHHIIKFGTNIDLSDAKRWKPQLQELLKLPAFMRVTSTG-----------NMLSHVG 1366

  Fly   615 ADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCA-----EQFEETM-- 672
            ..|.|||...:|:.:..:....|.|::...|:| ::.|        ||.|.     |.:.||:
Mouse  1367 HTILGMNTVQLYMKVPGSRTPGHQENNNFCSVN-INIG--------PGDCEWFAVHEHYWETISA 1422

  Fly   673 ---KQAAPELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYH--------- 725
               :.....|..|...:|..|..         :.:||:|..|..|:.|.......|
Mouse  1423 FCDRHGVDYLTGSWWPILDDLYA---------SNIPVYRFVQRPGDLVWINAGTVHWVQATGWCN 1478

  Fly   726 -AGFNQG--------------------------------YNFAEAVNFAPADWLKMGRECVNHYS 757
             ..:|.|                                :|.|..|..:..|..||
Mouse  1479 NIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVSWNVARTVKISDPDLFKM--------- 1534

  Fly   758 MLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAERRAFE- 821
              .:||:           |:..|       .|.:....:|...||:               |::
Mouse  1535 --IKFCL-----------LQSMK-------HCQVQRESLVRAGKKI---------------AYQG 1564

  Fly   822 LVNDDER-HCQECNTTCF-LSAVACECNDKLIVCLRHYTVLC-GCAPEKH------TLIYRYTLD 877
            .|.|:.. :|.||:...| :..|..|...:     ..|.|.| |||..:.      .::.:|..:
Mouse  1565 RVKDEPAYYCNECDVEVFNILFVTSENGSR-----NTYLVHCEGCARRRSAGLQGVVVLEQYRTE 1624

  Fly   878 EM 879
            |:
Mouse  1625 EL 1626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm5	NP_523486.1	JmjN	160..201	CDD:128818	10/41 (24%)
		ARID_JARID	226..312	CDD:350628	15/98 (15%)
		PHD1_Lid_like	450..495	CDD:277078	11/67 (16%)
		JmjC	624..740	CDD:396791	28/167 (17%)
		zf-C5HC2	830..882	CDD:460750	14/58 (24%)
		PLU-1	896..1231	CDD:462475
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
Kdm6b	XP_030101676.1	BepA	<90..154	CDD:443813
		TPR repeat	106..136	CDD:276809
		JmjC	1342..1406	CDD:214721	16/83 (19%)
		JmjC	1376..1484	CDD:396791	23/125 (18%)