DRSC/TRiP Functional Genomics Resources

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Protein Alignment Kdm5 and Kdm5a

DIOPT Version :10

Sequence 1:NP_523486.1 Gene:Kdm5 / 33837 FlyBaseID:FBgn0031759 Length:1838 Species:Drosophila melanogaster
Sequence 2:NP_666109.2 Gene:Kdm5a / 214899 MGIID:2136980 Length:1690 Species:Mus musculus


Alignment Length:1788 Identity:716/1788 - (40%)
Similarity:994/1788 - (55%) Gaps:275/1788 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 FDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRL 219
            |..|||||||.|:.|||.:||::|.:||..|||.||.||.||..|.||||.:|...||.||||||
Mouse    13 FVPPPECPVFEPSWEEFTDPLSFIGRIRPFAEKTGICKIRPPKDWQPPFACEVKTFRFTPRVQRL 77

  Fly   220 NELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKV 284
            |||||.|||:|:||||:|||||||||:||||:||||.||||.|.:||..:||.|..||::||:||
Mouse    78 NELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYALSKIVASKGGFEIVTKEKKWSKV 142

  Fly   285 ANRMQYPSSKSVGATLKAHYERILHPFEVYTSG-KVLGPTPTSSGSGSTPVKLEDGG-------- 340
            .:|:.|...|..|:.||:||||||:|:|::.|| .::|            |::.|..        
Mouse   143 GSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG------------VQMPDLDLKEKVEAE 195

  Fly   341 --GTDYK-AHEIPTRQQIAPPNETNTRRSKRFGNSNASCGLS-----GVTPTTKPSAGVFVKTET 397
              .||.: :.|..||..|.|......:.....|..|.:..|.     |..|..   .|:.|..:.
Mouse   196 VLSTDIQPSPERGTRMNIPPKRTRRVKSQSDSGEVNRNTELKKLQIFGAGPKV---VGLAVGAKD 257

  Fly   398 KEE---FKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALIVDPLMKYICHICNRGDV 459
            ||:   .:|.:.:..:|.|              ....|:||    .|.|:.:..|:|..|.||:.
Mouse   258 KEDEVTRRRKVTNRSDAFN--------------MQMRQRKG----TLSVNFVDLYVCMFCGRGNN 304

  Fly   460 EESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGFEQAEREYTLQQFGQM 524
            |:.:|||||||||||||||||||..:|||:|.||:||.||.:||:||||||||.||||||.||:|
Mouse   305 EDKLLLCDGCDDSYHTFCLLPPLPDVPKGDWRCPKCVAEECNKPREAFGFEQAVREYTLQSFGEM 369

  Fly   525 ADQFKQEYFRKPVHLVPTEMVEREFWRIVSSIDEDVTVEYGADLHTMDHGSGFPTK-SSLYLLPG 588
            ||.||.:||..|||:||||:||:||||:||||:|||.||||||:.:.|.|||||.| ....:||.
Mouse   370 ADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGSGFPKKDGQRKMLPE 434

  Fly   589 DQEYAESSWNLNNLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGE 653
            ::|||.|.|||||:|:||.|:|.|||.|||||..||:||||||::||||.|||||||||||||||
Mouse   435 EEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSFCWHIEDHWSYSINYLHWGE 499

  Fly   654 PKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVI 718
            ||||||||...|||.||.|::.|||||.||||||||||||||||:||.:.|||:||:|.|||||:
Mouse   500 PKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIMNPNVLMEHGVPVYRTNQCAGEFVV 564

  Fly   719 TFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHYSMLRRFCVFSHDELVCKMALEPAKLTF 783
            |||||||:||||||||||||||..||||.:||:|||||..|||.|||||:||:.|||.:|..|..
Mouse   565 TFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVNHYRRLRRHCVFSHEELIFKMAADPECLDV 629

  Fly   784 GIATACYIDMAEMVDTEKKLRKSLLEWGVTRAERRAFELVNDDERHCQECNTTCFLSAVACECND 848
            |:|.....::..|.:.|.:||:|:::.||..:|...||||.||||.|..|.|||||||:.|.||.
Mouse   630 GLAAMVCKELTLMTEEETRLRESVVQMGVVMSEEEVFELVPDDERQCSACRTTCFLSALTCSCNP 694

  Fly   849 KLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMPLMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVT 913
            :.:|||.|.|.||.|..:...|.|||.|:::|.:|..:||:|.|::.|::|..:.:.|.......
Mouse   695 ERLVCLYHPTDLCSCPMQNKCLRYRYPLEDLPSLLYGVKVRAQSYDTWVNRVTEALSASFNHKKD 759

  Fly   914 LQELQELCKEAETKKFPSSLLIDRLNAAAVEAEKCVTVIQQLGINKVRTRSDHNQEAAQYKLTME 978
            |.||:.:.::||.:|:|.:.|..:|..|..|||.|.:|.|.|...|.:.|...:....:.|||:|
Mouse   760 LIELRVMLEDAEDRKYPENDLFRKLRDAVKEAETCGSVAQLLLSKKQKHRQSSDSGKTRTKLTVE 824

  Fly   979 ELELFVQEIDNLCCIIDEGASVRELLVLGKQFVERSESQLQLSLESLEESELETLINEGSSLRIE 1043
            ||:.|||::.:|.|:|.:...|:.||...::|.||::..:.  .|:.:.|:|:.||:.||||.:|
Mouse   825 ELKAFVQQLVSLPCVISQTRQVKNLLDDVEEFHERAQEAMM--DETPDSSKLQMLIDMGSSLYVE 887

  Fly  1044 LQQLDLLQKRLKQCKWYKRSQGLRETSSKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQIGA 1108
            |.:|..|::.|:|.:|....:.......::|...:|.|:. :...|.|... |:|.|.:||::..
Mouse   888 LPELPRLKQELQQARWLDEVRLTLSDPQQVTLDVMKKLID-SGVGLAPHHA-VEKAMAELQELLT 950

  Fly  1109 DIEAWESQAAKYFRRLTQQHELGEIEQFLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQN 1173
            ..|.|| :.||...:...:|.:..:|..:..|.:|...:|:...||:||:|||||...||.:|..
Mouse   951 VSERWE-EKAKVCLQARPRHSMANLENIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSG 1014

  Fly  1174 NHVTYCHTLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSD 1238
            |:..|...||::..:|..||::|:.|.:::..:.:|..|::.|...||||.:.:|||:||.||:|
Mouse  1015 NNYAYLEQLESLSAKGRPIPVRLDALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTD 1079

  Fly  1239 AINI---------------------DSDLKP--RFQDDFLKEKNPAEIVASFKHAEEQELLDMRE 1280
             |.:                     |.||:|  ..::...:.::.|.:||.||..|::|:..|..
Mouse  1080 -IGVYGSGKNRRKKVKEIIEKEKEKDLDLEPLSDLEEGLEESRDTAMVVAVFKEREQKEIEAMHS 1143

  Fly  1281 LRRQNMNKNPMRD-----MFCLCKSEFRNLMFNCQLCRDWFHEDCVPPPSATNQNGIVNGGSGPG 1340
            ||..|:.|..:.:     .||:|:......|..|:||:||||..|||.|.:::|    ..||...
Mouse  1144 LRAANLAKMTIVERIEEVKFCICRKTASGFMLQCELCKDWFHNSCVPLPKSSSQ----KKGSSWQ 1204

  Fly  1341 TNRPKWLCPSCVRSKRPRLETILPLLVQLQQLPIRLPEDEALRCLAERAMNWQDRARKALSSPDV 1405
            ....|:|||.|:||:||||||||.|||.||:||:||||.|||:||.||||:|||:||:||::.::
Mouse  1205 AKDVKFLCPLCMRSRRPRLETILSLLVSLQKLPVRLPEGEALQCLTERAMSWQDKARQALATDEL 1269

  Fly  1406 SAAQEAI------MAQQQQKRRSEGGAGVGNISSPRKPRRRGSL-----------TKEASGS--- 1450
            |:|...:      |.:|..:.::|.........:...|..:|.|           ....|.|   
Mouse  1270 SSALAKLSVLSQRMVEQAAREKTEKIISAELQKAAANPDLQGHLPSFQQSAFNRVVSSVSSSPHQ 1334

  Fly  1451 ------TESDADDD-------DDEDECRLR---IVEDNFSNDED--------------------- 1478
                  .|:|:|:|       |.:|...::   .:|.|...||:                     
Mouse  1335 TMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFCAE 1399

  Fly  1479 -------------------EPRTAP-ATSTVNSDLLKLLSDSEIENLLDLMMEGDLLEVSLDETQ 1523
                               :||.:| ...::...:|:|...::.: |.:|||.||||||||||||
Mouse  1400 HAYSSASKSCSQGSSTPRKQPRKSPLVPRSLEPPVLELSPGAKAQ-LEELMMVGDLLEVSLDETQ 1463

  Fly  1524 ELWRILE-TMPPTLLQAEAMERVVQYMQRQRQQHTNPLPTSGAEDSNDSLMVQNSPNSNSNSGGA 1587
            .:||||: |.||      :.:|.:..|:....:. .||...| :||::....:.........|..
Mouse  1464 HIWRILQATHPP------SEDRFLHIMEDDSIEE-KPLKMKG-KDSSEKKRKRKLEKVEQLFGEG 1520

  Fly  1588 TGSAS-----NSGRNKKRRSN-DTGGNSAVPRKKQSTPKQTPGKKGSAAAARKSDAKASPAASTT 1646
            .....     :..:.||.:.| |.........||.:..::...||..||||:....|.       
Mouse  1521 KQKTKELKKIDKPKKKKLKLNVDKSKELNKLAKKLAKEEERKKKKEKAAAAKVELVKE------- 1578

  Fly  1647 PGADADAENKQANGGNTNSSTGSGGGNSATTTPTPGSTHKKRKRTSTTATNNNNNNNNNSTNNSN 1711
                                                ||.|||:|......:..:           
Mouse  1579 ------------------------------------STEKKRERKVLDIPSKYD----------- 1596

  Fly  1712 SSTNLNSNTTSGQGAATGGNNATGGQKKHAQRSQQAAQEDDEEE--CRAENCHKPTGREVDWVQC 1774
                     .||                        |:|.|:|.  |.|:||.:|...:||||||
Mouse  1597 ---------WSG------------------------AEESDDENAVCAAQNCQRPCKDKVDWVQC 1628

  Fly  1775 DGGCNEWFHMYCVGLNRSQIKPDDDYICIRCTK 1807
            ||||:||||..|||:: :::..::|||||.|.|
Mouse  1629 DGGCDEWFHQVCVGVS-AEMAENEDYICINCAK 1660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Kdm5NP_523486.1 JmjN 160..201 CDD:128818 24/40 (60%)
ARID_JARID 226..312 CDD:350628 54/85 (64%)
PHD1_Lid_like 450..495 CDD:277078 30/44 (68%)
JmjC 624..740 CDD:396791 93/115 (81%)
zf-C5HC2 830..882 CDD:460750 26/51 (51%)
PLU-1 896..1231 CDD:462475 106/334 (32%)
PHD2_KDM5A 1295..1351 CDD:277079 22/55 (40%)
PHD3_KDM5A_like 1755..1805 CDD:277083 27/51 (53%)
Kdm5aNP_666109.2 JmjN 18..59 CDD:128818 24/40 (60%)
ARID_KDM5A 84..175 CDD:350637 55/90 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..229 5/25 (20%)
PHD1_KDM5A 295..343 CDD:277075 32/47 (68%)
GSGFP motif. /evidence=ECO:0000269|PubMed:20064375 419..423 3/3 (100%)
JmjC 470..586 CDD:396791 93/115 (81%)
zf-C5HC2 676..728 CDD:460750 26/51 (51%)
PLU-1 741..1072 CDD:462475 106/335 (32%)
PHD2_KDM5A 1163..1215 CDD:277079 22/55 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1327..1346 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1407..1435 3/27 (11%)
PHD3_KDM5A 1608..1659 CDD:277156 27/51 (53%)
Interaction with LMO2. /evidence=ECO:0000250|UniProtKB:P29375 1622..1690 24/40 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1662..1690
Blue background indicates that the domain is not in the aligned region.

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