DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and Kdm5d

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_035549.1	Gene:	Kdm5d / 20592	MGIID:	99780	Length:	1548	Species:	Mus musculus

Alignment Length:	1537	Identity:	664/1537 - (43%)
Similarity:	906/1537 - (58%)	Gaps:	199/1537 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 FDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRL 219
            |..|||||||.|:..||::||.||:|||.||||.||.||.|||.|.|||||:||..||.||:|||
Mouse     8 FLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRL 72

  Fly   220 NELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKV 284
            |||||:||||||:|||||||||:||||||||.||||.||||:|::||.||||.|...|||:||:|
Mouse    73 NELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLNKIVMEEGGYEAICKDRRWARV 137

  Fly   285 ANRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEI 349
            |.|:.|||.|::|:.|::|||||::|:|::.||..|....|.      |...|: ...:||.|.|
Mouse   138 AQRLNYPSGKNIGSLLRSHYERIIYPYEIFQSGANLVQCNTD------PFDSEE-RDKEYKPHSI 195

  Fly   350 PTRQQIAPPN-ETNTRRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEF-KRDLLSSFNAV 412
            |.||.:.|.. ...:||.||            :.|..:|         |:|:. |...|......
Mouse   196 PLRQSVQPSKFSCYSRRGKR------------LQPEPEP---------TEEDIEKNPELKKLQIY 239

  Fly   413 NSGGSPLATGTTANTRGASQKKGGEP-------PALIV------------------------DPL 446
            .:|...:..|..|..:...:|...:|       ||.||                        :|.
Mouse   240 GAGPKMIGLGLKAKEKTLRKKDSKQPDKEEVTCPATIVVKGEASEFGKVTSAFSDKNLNHSFEPC 304

  Fly   447 MK-----------------YICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPR 494
            ||                 |:|.||:|||..:..||||||.|:||.|||||||:.:|||.|.||:
Mouse   305 MKMTMQLRNNHSSTQFMNSYVCRICSRGDEVDKFLLCDGCSDNYHIFCLLPPLSEVPKGVWRCPK 369

  Fly   495 CVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVSSIDED 559
            |::.|...|.||||||||.:|||||.||:|||.||.:||..|||:||||:||:||||:||||:||
Mouse   370 CILAECKSPPEAFGFEQATQEYTLQSFGEMADSFKADYFNMPVHMVPTEVVEKEFWRLVSSIEED 434

  Fly   560 VTVEYGADLHTMDHGSGFPTKSSLY-LLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMNAP 623
            ||||||||:|:.:.|||||..:|.: |.|.::|||...||||.:|:|:.|:|.|||||||||..|
Mouse   435 VTVEYGADIHSKEFGSGFPVNNSKWDLSPEEKEYAACGWNLNVMPVLDQSVLCHINADISGMKVP 499

  Fly   624 WMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLH 688
            |:||||.|:|||||.|||||||||||||||||||||||...||..|:.||:..||||.|||||||
Mouse   500 WLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEDVMKRLTPELFDSQPDLLH 564

  Fly   689 QLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECV 753
            ||||:||||.||::.|||.||:|.|||||||||||||:||||||||||||||..||||.:||:|:
Mouse   565 QLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPVGRQCI 629

  Fly   754 NHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAERR 818
            .||..|||:|||||:||:||||..|.||...:|.|.:.:|..||..|::|||:|||.|:|.|||.
Mouse   630 EHYRRLRRYCVFSHEELICKMAAFPEKLDLNLAVAVHKEMFIMVQEERRLRKTLLEKGITEAERE 694

  Fly   819 AFELVNDDERHCQECNTTCFLSAVAC-ECNDKLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMPLM 882
            ||||:.||||.|.:|.|||||||:|| :|.|.| |||.|...||.|:..:..|.|||||||:|.|
Mouse   695 AFELLPDDERQCIKCKTTCFLSALACYDCPDSL-VCLSHINDLCKCSRNRQYLRYRYTLDELPAM 758

  Fly   883 LQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLIDRLNAAAVEAEK 947
            |||||::|.||:.|.::.:..::.......:.:||:.|..||..::||:|.|:.||.....|||.
Mouse   759 LQKLKIRAESFDNWANKVQAALEVEDGRKRSFEELRALESEARDRRFPNSELLQRLKKCLTEAEA 823

  Fly   948 CVTVIQQLGINKVRTRSDHNQEAAQYKLTMEELELFVQEIDNLCCIIDEGASVRELLVLGKQFVE 1012
            |::  |.||:  :....|..|..   ::|:.||:|.::::..|.|.:.:...|:::|    |.||
Mouse   824 CIS--QVLGL--ISNSEDRLQTP---QITLTELQLLLKQMGTLPCTMHQIDEVKDVL----QQVE 877

  Fly  1013 RSESQLQLSLESLEES--ELETLINEGSSLRIELQQLDLLQKRLKQCKWYKR-SQGLRETSSKLT 1074
            ..:.:.:.:|.||..|  .|::|:.:|..||:|:.:...|::.|:|.:|..: .|.|..:..:.:
Mouse   878 SYQIETREALTSLPYSLEILQSLMEKGQQLRVEVPEAHQLEELLEQAQWLDQVKQALAPSGQRHS 942

  Fly  1075 YQDVKNLL----HIAAADLDPTDPYVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHELGEIEQ 1135
            ...:|.||    .:|::      |.|:|...:||::....|.|| :.|.:..:.:|:|....:|.
Mouse   943 LVIMKKLLVMGTKVASS------PSVNKARAELQELLTIAECWE-EKAHFCLKASQKHSPATLEV 1000

  Fly  1136 FLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQNNHVTYCHTLEAMIERGLNIPIQLEELS 1200
            .::.|.:|...:|:...||:||.||:.|:..|.::|..:|......||.::..|.::|::||||.
Mouse  1001 IIREAENIPVYLPNIQSLKEALTKAQAWIADVNEIQNGDHYPCLDDLEGLVAVGRDLPVELEELR 1065

  Fly  1201 RMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINI-----------------DSDLKP 1248
            :::..:.:||.||:..:..||||.:.|||||||.|.:||.::                 |::|..
Mouse  1066 QLENQVLTAHSWKEKASKTFLKKNSCYTLLEVLCPCADAGSVSTKRSRWIEKEMGLYKYDTELLG 1130

  Fly  1249 RFQDDFLKEKNPAEIVASFKHAEEQELLDMRELRRQNMNK-NPMRD-------MFCLCKSEFRNL 1305
            ....|.   ::|..::.:||..||:|...:..||..|..| :||..       ..|:|......:
Mouse  1131 LSAQDL---RDPGSVIMAFKEGEEKEKEGILHLRHINSAKPSPMSSSMNASATSICICGQVCAGV 1192

  Fly  1306 -MFNCQLCRDWFHEDCVPPPSATNQNGIVNGGSGPGTNR---------PKWLCPSCVRSKRPRLE 1360
             ...|.||.||||..||..|.      :::......|:.         .|:|||.|:||:|||||
Mouse  1193 ESLQCDLCHDWFHGQCVTVPH------LLSSVRASHTSSQLLAWWEWDTKFLCPLCMRSRRPRLE 1251

  Fly  1361 TILPLLVQLQQLPIRLPEDEALRCLAERAMNWQDRARKALSSPDVSAAQEAIMAQQQQKRRSEGG 1425
            |||.|||.||:|.:||||.|||:||.|||:.||.|||:||:|.||:|     :.:|.:|.|.:..
Mouse  1252 TILSLLVGLQRLSVRLPEGEALQCLTERAIGWQGRARQALASEDVTA-----LLKQLEKSRQQLQ 1311

  Fly  1426 AGVGNISSPRKPRRRGSLTKEASG-----STESDADDDDDEDECRLRIVEDNFSNDEDEPRTAPA 1485
            ..:.:...|..|          ||     .||:...|...|:| .|.:.|:...:.|   :..|.
Mouse  1312 DELRHKKPPTLP----------SGFAFDCLTENSGKDILKEEE-ELVLNEERIKSSE---KIVPK 1362

  Fly  1486 TSTVNSD------LLKLLSDSEIE-------NLLDLMMEGDLLEVSLDETQELWRILET-MPP-- 1534
            .|:...|      ||..|:...:|       .|.:||||||||||:|||...:|::|:. ..|
Mouse  1363 ESSCKGDKELLPSLLSQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENYSIWQLLQAGQNPNL 1427

  Fly  1535 ----TLLQAEAMER-----VVQYMQRQRQQHTNPLPTSGAED 1567
                |||:.|..|.     ..|..:|:||:....:.:...||
Mouse  1428 ERIHTLLELEKPENPGNWSEEQTPERRRQRRQKVVLSRKGED 1469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	27/40 (68%)
		ARID	227..312	CDD:198082	58/84 (69%)
		PHD1_Lid_like	450..495	CDD:277078	28/44 (64%)
		JmjC	624..740	CDD:202224	91/115 (79%)
		zf-C5HC2	830..882	CDD:280996	30/52 (58%)
		PLU-1	896..1229	CDD:285609	94/339 (28%)
		PHD2_KDM5A	1295..1351	CDD:277079	17/65 (26%)
		PHD3_KDM5A_like	1755..1805	CDD:277083
Kdm5d	NP_035549.1	JmjN	13..54	CDD:128818	27/40 (68%)
		BRIGHT	80..170	CDD:128777	59/89 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..229		8/41 (20%)
		PHD1_KDM5C_5D	325..370	CDD:277077	28/44 (64%)
		JmjC	500..616	CDD:202224	91/115 (79%)
		zf-C5HC2	706..758	CDD:280996	30/52 (58%)
		PLU-1	771..1094	CDD:285609	94/340 (28%)
		PHD_SF	1182..1242	CDD:304600	17/65 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1438..1468		5/29 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841792
Domainoid	1	1.000	221	1.000	Domainoid score	I2586
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1244	1.000	Inparanoid score	I183
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53001
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	1	1.000	-	-		FOG0000761
OrthoInspector	1	1.000	-	-		otm42729
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770