DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and Kdm5c

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	XP_006528832.1	Gene:	Kdm5c / 20591	MGIID:	99781	Length:	1554	Species:	Mus musculus

Alignment Length:	1635	Identity:	686/1635 - (41%)
Similarity:	938/1635 - (57%)	Gaps:	247/1635 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 FDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRL 219
            |..|||||||.|:..||::||.||:|||.||||.||.||.|||.|.|||||:||..||.||:|||
Mouse     8 FLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRL 72

  Fly   220 NELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKV 284
            |||||:||||||:|||||||||:||||||||.|||:.||||:|.:||.||||.|...|||:||:|
Mouse    73 NELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYETICKDRRWARV 137

  Fly   285 ANRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEI 349
            |.|:.||..|::|:.|::|||||::|:|:|.||..|....|.........|       :||.|.|
Mouse   138 AQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRPFDNEEKDK-------EYKPHSI 195

  Fly   350 PTRQQIAPPNETNT--RRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEF-KRDLLSSFNA 411
            |.||.: .|::.|:  ||:||            :.|..:|         |:|:. |...|.....
Mouse   196 PLRQSV-QPSKFNSYGRRAKR------------LQPDPEP---------TEEDIEKNPELKKLQI 238

  Fly   412 VNSGGSPLATGTTA--NTRGASQKKGGE-PPALIV-----------------------------D 444
            ..:|...:..|..|  .|.....|:|.| ||.::|                             :
Mouse   239 YGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKMESTSPKTFLEGKEELSHSPE 303

  Fly   445 PLMK-----------------YICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLC 492
            |..|                 |:|.:|:|||.::.:||||||||:||.|||||||..||||.|.|
Mouse   304 PCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRC 368

  Fly   493 PRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVSSID 557
            |:||:.|..:|.||||||||.||||||.||:|||.||.:||..|||:||||:||:||||:|:||:
Mouse   369 PKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIE 433

  Fly   558 EDVTVEYGADLHTMDHGSGFP-TKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMN 621
            ||||||||||:|:.:.||||| :.|..:|.|.::|||.|.||||.:|:||.|:|.|||||||||.
Mouse   434 EDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMK 498

  Fly   622 APWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDL 686
            .||:||||.|:|||||.|||||||||||||||||||||||...||..||.||:..||||.|||||
Mouse   499 VPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDL 563

  Fly   687 LHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRE 751
            ||||||:||||.||::.|||.||:|.|||||||||||||:||||||||||||||..||||..||:
Mouse   564 LHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQ 628

  Fly   752 CVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAE 816
            |:.||..|||:|||||:||:||||..|.||...:|.|.:.:|..||..|::|||:|||.|:|.||
Mouse   629 CIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITEAE 693

  Fly   817 RRAFELVNDDERHCQECNTTCFLSAVAC-ECNDKLIVCLRHYTVLCGCAPEKHTLIYRYTLDEMP 880
            |.||||:.||||.|.:|.|||||||:|| :|.|.| |||.|...||.|:..:..|.|||||||:|
Mouse   694 REAFELLPDDERQCIKCKTTCFLSALACYDCPDGL-VCLSHINDLCKCSSSRQYLRYRYTLDELP 757

  Fly   881 LMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLIDRLNAAAVEA 945
            .||.||||:|.||:.|.::.|..::.......:|:||:.|..||..::||:|.|:.||.....||
Mouse   758 AMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQRLKNCLSEA 822

  Fly   946 EKCVTVIQQLGINKVRTRSDHNQEA-----AQYKLTMEELELFVQEIDNLCCIIDEGASVRELLV 1005
            |.||:  :.||:..       .|||     |..::|:.||..|:.:::||.|.:.:...|:.:|
Mouse   823 EACVS--RALGLVS-------GQEAGPDRVAGLQMTLAELRDFLGQMNNLPCAMHQIGDVKGIL- 877

  Fly  1006 LGKQFVERSESQLQLSLESLEESE--LETLINEGSSLRIELQQLDLLQKRLKQCKW---YKRSQG 1065
               :.||..:::.:.:|.|...|.  |::|:..|..|.:|:.:...||::::|.:|   .||:
Mouse   878 ---EQVEAYQTEAREALVSQPSSPGLLQSLLERGQQLGVEVPEAQQLQRQVEQARWLDEVKRT-- 937

  Fly  1066 LRETSSKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHEL 1130
            |..::.:.|...::.|| :|.|.:.|: |.|||...:||::....|.|| :.|.......|:|..
Mouse   938 LAPSARRGTLAIMRGLL-VAGASVAPS-PAVDKAQAELQELLTIAERWE-EKAHLCLEARQKHPP 999

  Fly  1131 GEIEQFLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQNNHVTYCHTLEAMIERGLNIPIQ 1195
            ..:|..:..|.:|...:|:...||:||.|||.|:..|:::|..:|......||.::..|.::|:.
Mouse  1000 ATLEAIIHEAENIPVHLPNIQSLKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVG 1064

  Fly  1196 LEELSRMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINIDSDLKPRFQDDFLKE--- 1257
            ||||.:::..:.:||.|::..:..||||.:.|||||||.|.:|| ..||..:.|:.:   ||
Mouse  1065 LEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADA-GSDSTKRSRWME---KELGL 1125

  Fly  1258 ---------------KNPAEIVASFKHAEEQELLDMRELRRQNMNK-NPMRDM--------FCLC 1298
                           ::|..::.:||..|::|...:.:|||.|..| :|:..:        .|:|
Mouse  1126 YKSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLALLTTASSTASICVC 1190

  Fly  1299 KSEFRNL-MFNCQLCRDWFHEDCVPPPSATNQNGIVNGGSGPGTNRPKW-------LCPSCVRSK 1355
            ......: ...|.||:||||..||..|...:.    ...|.|.:....|       |||.|:||:
Mouse  1191 GQVPAGVGALQCDLCQDWFHGRCVTVPRLLSS----QRSSLPSSPLLAWWEWDTKFLCPLCMRSR 1251

  Fly  1356 RPRLETILPLLVQLQQLPIRLPEDEALRCLAERAMNWQDRARKALSSPDVSA-------AQEAIM 1413
            ||||||||.|||.||:||:||||.|||:||.|||::||.|||:.|:|.:|:|       .::.:.
Mouse  1252 RPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQVLASEEVTALLGRLAELRQRLQ 1316

  Fly  1414 AQQQQKRR----SEGGAGVGNISSPRKPRRRG------SLTKEASGSTESDADDDDDEDECRLRI 1468
            |:.:.:..    |:||.|.||:     |:.:|      |:|.....:||..:...|.|
Mouse  1317 AESKPEESLAYPSDGGEGTGNM-----PKVQGLLENGDSVTSPEKVATEEGSGKRDLE------- 1369

  Fly  1469 VEDNFSNDEDEPRTAPATSTVNSDLLKLLSDSEIE-------NLLDLMMEGDLLEVSLDETQELW 1526
                                :.|.:|..||...:|       .|.:||||||||||:|||...:|
Mouse  1370 --------------------LLSSILPQLSGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIW 1414

  Fly  1527 RILET-MPP------TLLQAE------------AMERVVQYMQRQRQQHTNPLPTSGAEDSNDSL 1572
            ::|:. .||      |||:.|            |:||     :|:|:......|...|.:..:..
Mouse  1415 QLLQAGQPPDLKRVQTLLELEKAERHGSRTRGRALER-----RRRRKVDRGGEPDDPAREELEPK 1474

  Fly  1573 MVQNSPNSNSNSGGATGSASNSGRNKKRRSNDTGGN-SAVPRKKQSTPKQTPGKKGSAAAARKSD 1636
            .|::|           |..:...:.::....:|||. ..||.....:|.....:.|.........
Mouse  1475 RVRSS-----------GPEAEEVQEEEELEEETGGEVPPVPFPNSGSPSIQEDQDGLEPVLEAGS 1528

  Fly  1637 AKASPAASTT 1646
            ..::|.::.|
Mouse  1529 DTSAPFSTLT 1538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	27/40 (68%)
		ARID	227..312	CDD:198082	56/84 (67%)
		PHD1_Lid_like	450..495	CDD:277078	29/44 (66%)
		JmjC	624..740	CDD:202224	92/115 (80%)
		zf-C5HC2	830..882	CDD:280996	30/52 (58%)
		PLU-1	896..1229	CDD:285609	100/342 (29%)
		PHD2_KDM5A	1295..1351	CDD:277079	18/63 (29%)
		PHD3_KDM5A_like	1755..1805	CDD:277083
Kdm5c	XP_006528832.1	JmjN	13..54	CDD:128818	27/40 (68%)
		ARID_KDM5C_5D	79..170	CDD:350639	59/90 (66%)
		PHD1_KDM5C_5D	326..371	CDD:277077	29/44 (66%)
		JmjC	501..617	CDD:334913	92/115 (80%)
		zf-C5HC2	707..759	CDD:367254	30/52 (58%)
		PLU-1	772..1098	CDD:369871	100/343 (29%)
		PHD_SF	1187..1247	CDD:389947	18/63 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841791
Domainoid	1	1.000	221	1.000	Domainoid score	I2586
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1244	1.000	Inparanoid score	I183
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53001
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	1	1.000	-	-		FOG0000761
OrthoInspector	1	1.000	-	-		otm42729
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R628
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800