DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and Jarid2

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	NP_001191972.1	Gene:	Jarid2 / 16468	MGIID:	104813	Length:	1234	Species:	Mus musculus

Alignment Length:	990	Identity:	245/990 - (24%)
Similarity:	397/990 - (40%)	Gaps:	246/990 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKTEADNTTAAN---SGGGGVGSGTSSGGGASANGTATP--------ARRLRTRNSTGNGTNS 54
            :|.|||:.|.....   |.||...|...:..|..|:....|        .|:||      .|..:
Mouse   375 ISGKTESSNAKTRKQVLSLGGASKSTGPAASGLKASSRLNPKSCTKEVGGRQLR------EGLRN 433

  Fly    55 GSESVKKSNANDEPSTPVTPAGATGSHTHAPPGISPAV------------MERPMPSVPMNHASS 107
            ....::::...|:|.:|.........:..||...:.|.            .|.|..|:..|....
Mouse   434 SKRRLEEAQQVDKPQSPPKKMKGVAGNAEAPGKKASAASGEKSLLNGHVKKEVPERSLERNRPKR 498

  Fly   108 SVSASKKYHNSCPHPTPTPAPTGHKKSVHTQPHSSNK--FDQGKNE----EFHFDTPPECPVFRP 166
            : :|.|.......|......|..::.:  :||.||:|  ..|||.|    :..:....|.||.||
Mouse   499 A-AAGKNMLGKQAHGKTEGTPCENRST--SQPESSHKPHDPQGKPEKGSGKSGWAAMDEIPVLRP 560

  Fly   167 TTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRLNELEAKTRVKLN 231
            :.:||.:||.||..:|:..||.|:.:::||..|.|...:: |::|||.::|.:::|..:....:.
Mouse   561 SAKEFHDPLIYIESVRAQVEKYGMCRVIPPPDWRPECKLN-DEMRFVTQIQHIHKLGRRWGPNVQ 624

  Fly   232 FLDQIAKFWELQGSSL-KIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKVANRMQYP-SSK 294
            .|..|.|....||.:: ::|::....|||....|::.|.|||:|.|..:||.|:|:.::.| :::
Mouse   625 RLACIKKHLRSQGITMDELPLIGGCELDLACFFRLINEMGGMQQVTDLKKWNKLADMLRIPKTAQ 689

  Fly   295 SVGATLKAHYERILHPF-------------EVYTSGKVL----GPTPTSSGSGSTPVKLEDGGGT 342
            ...|.|:..|.:.|..:             ||....::|    ||             ||....:
Mouse   690 DRLAKLQEAYCQYLLSYDSLSPEEHRRLEKEVLMEKEILEKRKGP-------------LEGHTES 741

  Fly   343 D-YKAHEIPTRQQIAPPNETNTRRSKRFGNSNASCGL-SGVTPTTKPSAGVFVKTETKEEFKRDL 405
            | :|.|.:|                 ||...|   || .||||...      .:::.||
Mouse   742 DHHKFHSLP-----------------RFEPKN---GLVHGVTPRNG------FRSKLKE------ 774

  Fly   406 LSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALIVDPLMKYICHICNRGDVEESMLLCDGCD 470
                    .|.:||.||   ..|..:|:|                 .:....:.::.:|
Mouse   775 --------VGRAPLKTG---RRRLFAQEK-----------------EVVKEEEEDKGVL------ 805

  Fly   471 DSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRK 535
            :.:|                   :|:.:              .|..:|..|.:.|.......|.|
Mouse   806 NDFH-------------------KCIYK--------------GRSVSLTTFYRTARNIMNMCFSK 837

  Fly   536 PVHLVPTEMVEREFWRIVSSIDEDVTVEYGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNLN 600
              ...|.| :|:|:||:|...|..|.|..| .:.|..||||||...|       :.::...|||.
Mouse   838 --EPAPAE-IEQEYWRLVEEKDCHVAVHCG-KVDTNTHGSGFPVGKS-------EPFSRHGWNLT 891

  Fly   601 NLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCW-HNEDHWSYSINYLHWGEPKTWYGVPGSC 664
            .||....|||.|:.| :.|:..||:.:||.|:..|| .:::|..| |:|||.|....||.:|...
Mouse   892 VLPNNTGSILRHLGA-VPGVTIPWLNIGMVFSTSCWSRDQNHLPY-IDYLHTGADCIWYCIPAEE 954

  Fly   665 AEQFEETMKQAAPELFSSQPDLLHQLV--------------TIMNPNILMNNRVPVFRTDQHAGE 715
            ..:.|               |::|.|:              .:::|.:|....:.|.||.|.:|:
Mouse   955 ENKLE---------------DVVHTLLQGNGTPGLQMLESNVMISPEVLCKKGIKVHRTVQQSGQ 1004

  Fly   716 FVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHYSMLRRFCV--FSHDELVCKMALEP 778
            ||:.||.::.:....|||.:|.|:||...|..||.|...  .|.||...  ||.::|:.::|...
Mouse  1005 FVVCFPGSFVSKVCCGYNVSETVHFATTQWTSMGFETAK--EMKRRHIAKPFSMEKLLYQIAQAE 1067

  Fly   779 AKLTFG--IATACYIDMAEMVDTEKKLRKSLLEWGVTRAER-----------------RAFELVN 824
            ||...|  ::|...: :.|:.|||.:.|:.|.|.|:..:.|                 |.:..:.
Mouse  1068 AKKENGPTLSTISAL-LDELRDTELRQRRLLFEAGLHSSARYGSHDGNSTVADGKKKPRKWLQLE 1131

  Fly   825 DDERHCQECNTTCFLSAVACECNDKLIVC----LRHYTVLCGCAPEKHTLIYRYTLDEMPLMLQK 885
            ..||.||.|...|:||.|..| |:.::.|    |||......|...|  |:|||..:::..::.:
Mouse  1132 TSERRCQICQHLCYLSMVVQE-NENVVFCLECALRHVEKQKSCRGLK--LMYRYDEEQIISLVNQ 1193

  Fly   886 LKVKAHSFERWLSRC 900
            :..|.......:..|
Mouse  1194 ICGKVSGKHGGIENC 1208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	18/40 (45%)
		ARID	227..312	CDD:198082	25/99 (25%)
		PHD1_Lid_like	450..495	CDD:277078	2/44 (5%)
		JmjC	624..740	CDD:202224	36/130 (28%)
		zf-C5HC2	830..882	CDD:280996	19/55 (35%)
		PLU-1	896..1229	CDD:285609	1/5 (20%)
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
Jarid2	NP_001191972.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..150
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:12890668	104..110
		Sufficient for interaction with the PRC2 complex. /evidence=ECO:0000250\|UniProtKB:Q92833	141..170
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..339
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..548		39/181 (22%)
		JmjN	554..595	CDD:128818	18/40 (45%)
		ARID_JARD2	618..729	CDD:350634	27/110 (25%)
		GSGFP motif	872..876		3/3 (100%)
		JmjC	914..1029	CDD:396791	36/130 (28%)
		zf-C5HC2	1137..1190	CDD:397190	19/55 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1206..1234		1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920