Protein Alignment Kdm5 and Jarid2

DIOPT Version :10

• Sequence 1: NP_523486.1
• Gene: Kdm5 / 33837
• FlyBaseID: FBgn0031759
• Length: 1838
• Species: Drosophila melanogaster
• Sequence 2: XP_315541.5
• Gene: Jarid2 / 1276224
• VectorBaseID: AGAMI1_006796
• Length: 2538
• Species: Anopheles gambiae
• Alignment Length: 997
• Identity: 241/997 - (24%)
• Similarity: 378/997 - (37%)
• Gaps: 276/997 - (27%)

  Fly     1 MSAKTEADNTTA-ANSGGGGVG--------SGTSSGG---GASANGTATP------ARRLRTRNS 47
            ::.|.||.:|.| ..:||.|.|        .|.::||   |.|..|.::.      |.:|.|...
Mosquito  1631 LTVKQEASDTEADGGAGGSGAGGQTFYIPLQGPTAGGSTAGGSTGGKSSDQLIQGVAVKLGTEGP 1695

  Fly    48 TGNGTN--SGSESVKKSNANDEPST------------------------------PVTPAGATGS 80
            .|....  ..::.|.|:.....|:|                              .:.|.|...|
Mosquito  1696 DGPNQRVIMHAKLVTKAEMGSNPTTLPDSMNVQELVKSLTAQGGAAAALGKEGLAKLLPMGLLQS 1760

  Fly    81 HTHAPPGISPA--------VMERPMPSVPMNHASSSVSASKKYHNSCPHPTPTPAPTGHKK---- 133
            ...:|...:||        .:|....:.||:...|.::::....:.      ...|||.|.
Mosquito  1761 RLKSPTADAPAPSTDARTPTLEDRASAEPMSRGLSRIASNSSLSSQ------RSKPTGGKSNAKG 1819

  Fly   134 -------SVHT----QPHSSNKFDQGKNEEFHFDTPP---ECPVFRPTTEEFKNPLAYISKIRSI 184
                   ||.|    ||.::..|.:.       |.|.   |.|||:||.:||.:|:.||.:|..|
Mosquito  1820 GTGAGRGSVETVPPPQPDNNTVFPRR-------DDPAQMVEAPVFKPTEKEFHDPMEYIERIAPI 1877

  Fly   185 AEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRLNELEAKTRVKLNFLDQIAKFWELQGSSLKI 249
            |.:.||.:|:|||::.|...: .|.:||:...|.::::..:..........|.|:...|..:|:.
Mosquito  1878 ASRFGICRIVPPASFKPECRI-ADDMRFMAYNQYVHKMLHRWGPSAKEYAAIKKYLATQSINLQA 1941

  Fly   250 -PMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKVANRMQYPSSKSVGATLKAHYERILHPFEV 313
             |::....:||..|:..|||.||:::..:.:|||:|:..|..|         ||.::|:....::
Mosquito  1942 PPVIGGMEVDLPRLYHTVQELGGLKEVIEKKKWARVSEDMCIP---------KAAHDRVSKLDDI 1997

  Fly   314 YTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEIPTRQQIAPPNETNTRRSKRFGNSNASCGL 378
            |.  |.|.|..|.|                              |.|    |.|.|....|.
Mosquito  1998 YC--KYLLPYDTLS------------------------------PAE----RQKLFDEVEAD--- 2023

  Fly   379 SGVTPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKGGEPPALIV 443
                         :.|.|.|..                           |.|.:..|.|
Mosquito  2024 -------------WAKREAKAR---------------------------RNADKGVGSE------ 2042

  Fly   444 DPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCP-RCVVEEVSKPQEAF 507
                     |.|.||.:|.    |..||...            :.|..|. .|:|:..|.|
Mosquito  2043 ---------IRNSGDSDED----DSNDDEEE------------EDEDECSMECIVKGRSMP---- 2078

  Fly   508 GFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVSSIDEDVTVEYGADLHTMD 572
                      |.||.::|......:||.....|..  :|.|:||.|:..|..|.|..|: :.:..
Mosquito  2079 ----------LNQFFRIARNTMSLWFRNSEPTVAE--IEAEYWRHVAVRDSHVCVHSGS-IDSSA 2130

  Fly   573 HGSGFPT---KSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMNAPWMYVGMCFAAF 634
            .|.|||:   |.|        ..|:..|||..|.....|||..: ..:.|:..|.::|||.|:|.
Mosquito  2131 FGYGFPSPKVKGS--------SCAKHPWNLKVLTNNSGSILRSL-GPVMGITIPTLHVGMLFSAC 2186

  Fly   635 CWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQPDLLHQLVTIMNPNIL 699
            ||:.:.|....|.|||.|..|.|||||......|...:....|....::...|.....::.|::|
Mosquito  2187 CWYRDPHGLPWIEYLHTGANKIWYGVPDDQNANFRAALTVLVPTHCQNKTIWLPCDTAMVPPHML 2251

  Fly   700 MNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHYSMLRRFC- 763
            .:..|.:.||:|..|:||:.|||||.:....||..:|:|.||...||...:|   .:..::..|
Mosquito  2252 TDRSVSLCRTEQQPGQFVVVFPRAYTSSLCTGYAVSESVYFATNSWLDTAKE---DFRDIQESCE 2313

  Fly   764 --VFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAER-----RAFE 821
              :||.::|:..:| ...:.........|..:.::.:.||..|::|.|.|||::||     ::..
Mosquito  2314 PTMFSVEQLLFAIA-NDQRSNHDTLVQAYPMIVDIYEKEKLHRQTLKEQGVTKSERIESKKKSAS 2377

  Fly   822 LVNDDERHCQECNTTCFLSAVACEC------------------NDKLIVCLRHYT--VLCGCAPE 866
            |   ||..|:.|....:||.|..:.                  .::.|.||:|..  :..|....
Mosquito  2378 L---DELECERCRANLYLSLVKVKVTRSDDDDEEGDEDNTTVDEEERIYCLKHAVKHLADGGLQT 2439

  Fly   867 KH-TLIYRYTLDEMPLMLQKLK 887
            || .|.|.|:||::..:|:||:
Mosquito  2440 KHCRLAYTYSLDDIEELLKKLQ 2461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm5	NP_523486.1	JmjN	160..201	CDD:128818	20/40 (50%)
		ARID_JARID	226..312	CDD:350628	22/86 (26%)
		PHD1_Lid_like	450..495	CDD:277078	10/45 (22%)
		JmjC	624..740	CDD:396791	40/115 (35%)
		zf-C5HC2	830..882	CDD:460750	17/72 (24%)
		PLU-1	896..1231	CDD:462475
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
Jarid2	XP_315541.5	None