Protein Alignment Kdm5 and KDM5B

DIOPT Version :10

• Sequence 1: NP_523486.1
• Gene: Kdm5 / 33837
• FlyBaseID: FBgn0031759
• Length: 1838
• Species: Drosophila melanogaster
• Sequence 2: NP_001300971.1
• Gene: KDM5B / 10765
• HGNCID: 18039
• Length: 1580
• Species: Homo sapiens
• Alignment Length: 1770
• Identity: 690/1770 - (38%)
• Similarity: 934/1770 - (52%)
• Gaps: 289/1770 - (16%)

  Fly   121 HPTPTPA-PTGHKKSVHTQPHSSNKFDQGKNEEFHFDTPPECPVFRPTTEEFKNPLAYISKIRSI 184
            ||.|.|| |.|                 |......|..|||||||.|:.|||.:|.|:|.|||.|
Human     8 HPGPRPALPLG-----------------GPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPI 55

  Fly   185 AEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRLNELEAKTRVKLNFLDQIAKFWELQGSSLKI 249
            ||:.||.|:.||..|.||||.|||||.|.||:||||||||:|||||||||||||:||||||:|||
Human    56 AEQTGICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKI 120

  Fly   250 PMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKVANRMQYPSSKSVGATLKAHYERILHPFEVY 314
            |.||||.|||:.|:::|.||||.....|||||.|:|.:|.:...|:||:.::.||||||:|:.::
Human   121 PHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILNPYNLF 185

  Fly   315 TSGKVL----GPTPTSSGSGSTPVKLEDGGGTDYKAHEIPTRQQIAPPNET--NTRRSKRFGNSN 373
            .||..|    .|..|:           |....:||.|:||.||.: .|:||  ..||:||.....
Human   186 LSGDSLRCLQKPNLTT-----------DTKDKEYKPHDIPQRQSV-QPSETCPPARRAKRMRAER 238

  Fly   374 ASCGLSGVTPTTKPSAGVFVKTETKEEFKRDLLSSFN-------AVNSGGSPLATGTTANTRGAS 431
            .|.   .|.|..:.|..:......:      ||.|.|       |:|....|..| |.|.|....
Human   239 QSL---AVLPRLECSGAILAHCNLR------LLDSSNSSASASQAMNIKIEPEET-TEARTHNLR 293

  Fly   432 QKKGGEPPALIVDPLMK-----------------------------------YICHICNRGDVEE 461
            ::.|...|....:..||                                   |:|.:|..|:.|:
Human   294 RRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRSKKATNAVDLYVCLLCGSGNDED 358

  Fly   462 SMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMAD 526
            .:|||||||||||||||:|||..:|||:|.||:|:.:|.||||||||||||.|:|||:.||:|||
Human   359 RLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQECSKPQEAFGFEQAARDYTLRTFGEMAD 423

  Fly   527 QFKQEYFRKPVHLVPTEMVEREFWRIVSSIDEDVTVEYGADLHTMDHGSGFPTK-SSLYLLPGDQ 590
            .||.:||..|||:||||:||:||||:||:|:||||||||||:.:.:.|||||.: ..:.|.|.::
Human   424 AFKSDYFNMPVHMVPTELVEKEFWRLVSTIEEDVTVEYGADIASKEFGSGFPVRDGKIKLSPEEE 488

  Fly   591 EYAESSWNLNNLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPK 655
            ||.:|.|||||:|::|.|:|.||.|||.||..||:||||||::||||.|||||||||||||||||
Human   489 EYLDSGWNLNNMPVMEQSVLAHITADICGMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPK 553

  Fly   656 TWYGVPGSCAEQFEETMKQAAPELFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITF 720
            |||||||..|||.|..||:.|||||.||||||||||||||||.||.:.|||:||:|.||||||||
Human   554 TWYGVPGYAAEQLENVMKKLAPELFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITF 618

  Fly   721 PRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGI 785
            |||||:|||||:||||||||...|||.:||:||.||.:|.|:|||||||::||||.:...|...:
Human   619 PRAYHSGFNQGFNFAEAVNFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVV 683

  Fly   786 ATACYIDMAEMVDTEKKLRKSLLEWGVTRAERRAFELVNDDERHCQECNTTCFLSAVACECNDKL 850
            |:....|||.|::.||.||:::.:.||..:||..|||:.||||.|.:|.||||:||::|.|...|
Human   684 ASTVQKDMAIMIEDEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGL 748

  Fly   851 IVCLRHYTVLCGCAPEKHTLIYRYTLDEMPLMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQ 915
            :|||.|...||.|.|.|:.|.||||||::..|:..||::|.|:..|.....:.::|......:|.
Human   749 LVCLHHVKELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAESYNEWALNVNEALEAKINKKKSLV 813

  Fly   916 ELQELCKEAETKKFPSSLLIDRLNAAAVEAEKCVTVIQQLGINKVRTRSDHNQEAAQYKLTMEEL 980
            ..:.|.:|:|.||||.:.|:..|.....:||||.:|.|||...|.:||.......:|.:||:.||
Human   814 SFKALIEESEMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQNQLTVNEL 878

  Fly   981 ELFVQEIDNLCCIIDEGASVRELLVLGKQFVERSESQLQLSLESLEESELETLINEGSSLRIELQ 1045
            ..||.::..|.|::.:...:::||...:.|  :..||..||.|:...:||:.|::......:||.
Human   879 RQFVTQLYALPCVLSQTPLLKDLLNRVEDF--QQHSQKLLSEETPSAAELQDLLDVSFEFDVELP 941

  Fly  1046 QLDLLQKRLKQCKWYKRSQGLRETSSKLTYQDVKNLLHIAAADLDPTDPY--VDKEMRKLQQIGA 1108
            ||..::.||:|.:|.:..|......|.||..|::.|:.:...    ..||  |:|.|.:||::..
Human   942 QLAEMRIRLEQARWLEEVQQACLDPSSLTLDDMRRLIDLGVG----LAPYSAVEKAMARLQELLT 1002

  Fly  1109 DIEAWESQAAKYFRRLTQQHELGEIEQFLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQN 1173
            ..|.|:.: ||...:...:|.|..:...:|...:|...:|:...|||::::||:||:.||.||..
Human  1003 VSEHWDDK-AKSLLKARPRHSLNSLATAVKEIEEIPAYLPNGAALKDSVQRARDWLQDVEGLQAG 1066

  Fly  1174 NHVTYCHTLEAMIERGLNIPIQLEELSRMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSD 1238
            ..|....||..::.||.:||:.|..|.|::..:.....||:.....||.:.:.|:|||||.||.|
Human  1067 GRVPVLDTLIELVTRGRSIPVHLNSLPRLETLVAEVQAWKECAVNTFLTENSPYSLLEVLCPRCD 1131

  Fly  1239 AINIDSDLKPR---------------------FQDDFLKEKNPAEIVASFKHAEEQELLDMRELR 1282
            ...:....|.|                     .:....:.|..|..:|:...|..:|:..::.||
Human  1132 IGLLGLKRKQRKLKEPLPNGKKKSTKLESLSDLERALTESKETASAMATLGEARLREMEALQSLR 1196

  Fly  1283 RQNMNK--NPMRDM---FCLCKSEFRNLMFNCQLCRDWFHEDCVPPPSATNQNGIVNGGSGPGTN 1342
            ..|..|  :|::|:   .|||:......|..|:||||.||..||..||.:....|
Human  1197 LANEGKLLSPLQDVDIKICLCQKAPAAPMIQCELCRDAFHTSCVAVPSISQGLRI---------- 1251

  Fly  1343 RPKWLCPSCVRSKRPRLETILPLLVQLQQLPIRLPEDEALRCLAERAMNWQDRARKALSSPDVSA 1407
               ||||.|.||::|.||.|||||..||::.:||||.:|||.:.||.:|||.||::.|||.::..
Human  1252 ---WLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTVNWQHRAQQLLSSGNLKF 1313

  Fly  1408 AQEAIMAQQQQKRRSEGGAGVGNISSPRKPRRRGSLTKEASGSTESDADDDDDEDECRLRIVEDN 1472
            .|:.:.:.....|..   |..|.:|...|       ..:..|:|.....||.|.   |...:...
Human  1314 VQDRVGSGLLYSRWQ---ASAGQVSDTNK-------VSQPPGTTSFSLPDDWDN---RTSYLHSP 1365

  Fly  1473 FSNDEDEPRTAPATSTVNSDLLKLLSDSEIENLLDLMMEGDLLEVSLDETQELWRILETMPPTLL 1537
            ||...........:..||                :|:||..||:|||.|.|||::.|...|
Human  1366 FSTGRSCIPLHGVSPEVN----------------ELLMEAQLLQVSLPEIQELYQTLLAKP---- 1410

  Fly  1538 QAEAMERVVQYMQRQRQQHTNPLPTSGAEDSNDSLMVQNSPNSNSNSGGATGSASNSGRNKKRRS 1602
                                     |.|:.::.|..|:.|...|....|.....::..|..|||.
Human  1411 -------------------------SPAQQTDRSSPVRPSSEKNDCCRGKRDGINSLERKLKRRL 1450

  Fly  1603 NDTGGNSAVPR----KKQSTPKQTPGKKGSAAAARKSDAKASPAASTTPGADADAENKQANGGNT 1663
            ...|.:|  .|    ||..|||:
Human  1451 EREGLSS--ERWERVKKMRTPKK------------------------------------------ 1471

  Fly  1664 NSSTGSGGGNSATTTPTPGSTHKKRKRTSTTATNNNNNNNNNSTN--NSNSSTNLNSNTTSGQGA 1726
                                  ||.|.:.....||.......|..  .|..:.:|.|:|:
Human  1472 ----------------------KKIKLSHPKDMNNFKLERERSYELVRSAETHSLPSDTS----- 1509

  Fly  1727 ATGGNNATGGQKKHAQRSQQAAQEDDEEECRAENCHKPTGREVDWVQCDGGCNEWFHMYCVGLNR 1791
                            .|:|...||::..|.|.:|.:|.|.|||||||||.||:|||..|||::
Human  1510 ----------------YSEQEDSEDEDAICPAVSCLQPEGDEVDWVQCDGSCNQWFHQVCVGVS- 1557

  Fly  1792 SQIKPDDDYICIRCT 1806
            .::...:||||:|||
Human  1558 PEMAEKEDYICVRCT 1572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kdm5	NP_523486.1	JmjN	160..201	CDD:128818	24/40 (60%)
		ARID_JARID	226..312	CDD:350628	54/85 (64%)
		PHD1_Lid_like	450..495	CDD:277078	28/44 (64%)
		JmjC	624..740	CDD:396791	94/115 (82%)
		zf-C5HC2	830..882	CDD:460750	27/51 (53%)
		PLU-1	896..1231	CDD:462475	100/336 (30%)
		PHD2_KDM5A	1295..1351	CDD:277079	20/55 (36%)
		PHD3_KDM5A_like	1755..1805	CDD:277083	26/49 (53%)
KDM5B	NP_001300971.1	JmjN	31..72	CDD:128818	24/40 (60%)
		ARID_KDM5B	94..183	CDD:350638	56/88 (64%)
		PHD1_KDM5B	347..392	CDD:277076	28/44 (64%)
		JmjC	522..638	CDD:396791	94/115 (82%)
		zf-C5HC2	728..780	CDD:460750	27/51 (53%)
		PLU-1	793..1124	CDD:462475	100/337 (30%)
		PHD2_KDM5B	1214..1257	CDD:277080	20/55 (36%)
		PHD3_KDM5B	1522..1571	CDD:277157	26/49 (53%)