DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and Kdm5d

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	XP_008771910.1	Gene:	Kdm5d / 100312983	RGDID:	2314436	Length:	1560	Species:	Rattus norvegicus

Alignment Length:	1594	Identity:	673/1594 - (42%)
Similarity:	919/1594 - (57%)	Gaps:	175/1594 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 KNEEFHFDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFV 213
            |.|...|..|||||||.|:..||::||.||:|||.||||.||.||.|||.|.|||||::|..||.
  Rat     2 KPESDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEIDNFRFT 66

  Fly   214 PRVQRLNELEAKTRVKLNFLDQIAKFWELQGSSLKIPMVERKALDLYTLHRIVQEEGGMEQTTKD 278
            ||:||||||||:||||||:|||||||||:||||||||.||||.||||:|::||.||||.|...||
  Rat    67 PRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLNKIVIEEGGYEAICKD 131

  Fly   279 RKWAKVANRMQYPSSKSVGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTD 343
            |:||:||.|:.|||.|::|:.|::|||||::|:|::.||      .......:.|...|: ...:
  Rat   132 RRWARVAQRLNYPSGKNIGSLLRSHYERIIYPYEMFQSG------ANHVQCNTDPFDSEE-KDKE 189

  Fly   344 YKAHEIPTRQQIAPPN-ETNTRRSKR-----------------------FGNSNASCGL------ 378
            ||.|.||.||.:.|.. ...:||:||                       :|......||
  Rat   190 YKPHSIPLRQSVQPLKFSCYSRRAKRLQPEPEPTEEDIEKNPELKKLQIYGAGPKMIGLGLMAKE 254

  Fly   379 ------SGVTPTTKP-------------SAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTT 424
                  ..:.|...|             .|.|.||.|.....|.....|...:|....|....||
  Rat   255 KTLRKKGSIQPVCFPLLLMLLDKEEVTCPATVIVKGEASGFGKVTSAFSDKNLNHNFKPCTEMTT 319

  Fly   425 ANTRGASQKKGGEPPALIVDPLMKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGE 489
                   |.:........:|   .|:|.||:|||.::..|||.||:|:||.|||||||:.:|||.
  Rat   320 -------QLRNNHSNTQFMD---SYVCRICSRGDEDDRFLLCVGCNDNYHIFCLLPPLSEVPKGV 374

  Fly   490 WLCPRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIVS 554
            |.||:|::.|..:|.||||||||.:|||||.||:|||.||.:||..|||:||||:||:||||:||
  Rat   375 WRCPKCILAECKRPLEAFGFEQATQEYTLQSFGEMADSFKADYFNMPVHMVPTEVVEKEFWRLVS 439

  Fly   555 SIDEDVTVEYGADLHTMDHGSGFPTKSSLYLL-PGDQEYAESSWNLNNLPLLEDSILGHINADIS 618
            ||:||||||||||:|:.:.|||||..:|.:.| |.::|||.|.||||.:|:|:.|:|.|||||||
  Rat   440 SIEEDVTVEYGADIHSKEFGSGFPVNNSKWTLSPEEKEYAASGWNLNVMPVLDQSVLCHINADIS 504

  Fly   619 GMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPGSCAEQFEETMKQAAPELFSSQ 683
            ||..||:||||.|:|||||.|||||||||||||||||||||||...||..|:.||...||||.||
  Rat   505 GMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEDVMKTLTPELFDSQ 569

  Fly   684 PDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKM 748
            |||||||||:||||.||::.|||.||:|.|||||||||||||:||||||||||||||..||||.:
  Rat   570 PDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPV 634

  Fly   749 GRECVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMVDTEKKLRKSLLEWGVT 813
            ||:|:.||..|||:|||||:||:||||..|.||...:|.|.:.:|..||..|::|||:|||.|:|
  Rat   635 GRQCIEHYRRLRRYCVFSHEELICKMAAFPEKLDLNLAVAVHKEMFIMVQEERRLRKTLLEKGIT 699

  Fly   814 RAERRAFELVNDDERHCQECNTTCFLSAVAC-ECNDKLIVCLRHYTVLCGCAPEKHTLIYRYTLD 877
            .|||.||||:.||||.|.:|.|||||||:|| :|.|.| |||.|...||.|:..:..|.||||||
  Rat   700 EAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGL-VCLSHINDLCKCSRSRQYLRYRYTLD 763

  Fly   878 EMPLMLQKLKVKAHSFERWLSRCRDIVDAHTPTSVTLQELQELCKEAETKKFPSSLLIDRLNAAA 942
            |:|.||||||::|.||:.|.::.:..::.......:.:||:.|..||..::||::.|:.||....
  Rat   764 ELPAMLQKLKIRAESFDNWANKVQAALEVEDGRKRSFEELRALETEAHDRQFPNNDLLQRLKKCL 828

  Fly   943 VEAEKCVTVIQQLGINKVRTRSDHNQEAAQYKLTMEELELFVQEIDNLCCIIDEGASVRELLVLG 1007
            .|||.|::.:.:|..|     |:...|..|  ||:.||::.::::..|.|.|.:...|:::|
  Rat   829 TEAEACISQVLELVNN-----SEDRLETPQ--LTLTELQILLKQMCTLPCTIHQIDEVKDVL--- 883

  Fly  1008 KQFVERSESQLQLSLESLEES--ELETLINEGSSLRIELQQLDLLQKRLKQCKWYKR-SQGLRET 1069
             |.||..:.:.:.:|.||..|  .|::|:.:|..||:|:.:...|::.|:|.:|..: .|.|..:
  Rat   884 -QQVETYQIETREALTSLPYSLEILQSLMEKGQQLRVEVPEAHQLEELLEQAQWLDQVKQALAPS 947

  Fly  1070 SSKLTYQDVKNLLHIAAADLDPTDPYVDKEMRKLQQIGADIEAWESQAAKYFRRLTQQHELGEIE 1134
            ..|.:...:|.|| :....| .:.|.|:|...:||::....|.||.:|. :....:|:|....:|
  Rat   948 GQKHSLVIMKKLL-VMGTKL-ASSPSVNKARAELQELLTIAERWEEKAL-FCLDASQKHSPATLE 1009

  Fly  1135 QFLKSASDINGQVPSHGLLKDALRKAREWLRAVEQLQQNNHVTYCHTLEAMIERGLNIPIQLEEL 1199
            ..::.|.:|...:|:...||:||.||:.|:..|.::|..:|......||.::..|.::|::||||
  Rat  1010 VIIREAENIPVYLPNIQSLKEALTKAQAWIADVNEIQNGDHYPCLDDLEGLVAVGRDLPVELEEL 1074

  Fly  1200 SRMQGHLNSAHQWKDNTACAFLKKGTFYTLLEVLMPRSDAINI-----------------DSDLK 1247
            .:::..:.:||.||:..:..||||.:.|||||||.|.:||.::                 |::|.
  Rat  1075 KQLENQVLTAHSWKEKASKTFLKKNSCYTLLEVLCPCADAGSVSTKRSRWIEKEMGLYKYDTELL 1139

  Fly  1248 PRFQDDFLKEKNPAEIVASFKHAEEQELLDMRELRRQNMNK-NPMRD-------MFCLCKSEFRN 1304
            .....|.   ::|..::.:||..||:|...:..||..|..| :||..       ..|:|......
  Rat  1140 GLSAQDL---RDPGSVIMAFKEGEEKEKEGILHLRHINSTKPSPMSSSINASATSICICGQVRAG 1201

  Fly  1305 L-MFNCQLCRDWFHEDCVPPPSATNQNGIVNGGSGPGTNR---------PKWLCPSCVRSKRPRL 1359
            : ...|.||.||||..||..|.      :::......|:.         .|:|||.|:||:||||
  Rat  1202 VEALRCDLCHDWFHGQCVTVPH------LLSSLRASHTSSQLLAWWEWDTKFLCPLCMRSRRPRL 1260

  Fly  1360 ETILPLLVQLQQLPIRLPEDEALRCLAERAMNWQDRARKALSSPDVSAAQEAIMAQQQQKRRSEG 1424
            ||||.|||.||:|.:||||.|||:||.|||:.||.|||:||:|.:|:|..:.:...:||.:
  Rat  1261 ETILSLLVGLQRLSVRLPEGEALQCLTERAIGWQGRARQALASENVTALLKQLAKSRQQLQ---- 1321

  Fly  1425 GAGVGNISSPRKPRRRGSLTKEASGSTESDADDDDDEDECRLRIVEDNFSNDEDEPRTAPATSTV 1489
                ..:...:.|.....|..|.  .|| |:|.|..::|..|.:.||...|.|   :..|..|:.
  Rat  1322 ----DELRHEKPPTSHSGLPSEC--LTE-DSDKDILKEEEELVLNEDMLKNSE---KIVPKESSC 1376

  Fly  1490 N------SDLLKLLSDSEIE-------NLLDLMMEGDLLEVSLDETQELWRILET-MPP------ 1534
            .      ..||..|:...:|       .|.:||||||||||:|||...:|::|:. ..|
  Rat  1377 ERGEELLPSLLSQLTGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQNPNLERIH 1441

  Fly  1535 TLLQAEAMERVVQYMQ------RQRQQHTNPLPTSGAEDSNDSLMVQNSPNSNSNSGGATGSASN 1593
            |||:.|..|....:.:      |||::....|...|.:.:...|..:.:.:|.....|.......
  Rat  1442 TLLELEKPEDPKNWSEEQTPERRQRRRQKVVLSRKGEDLTQKELASKRARSSRIKPKGKQFQEPI 1506

  Fly  1594 SGRN-----KKRRSNDTGGNSAVPRKKQSTPKQT 1622
            .|.|     ....:|...||....:.|..:|..|
  Rat  1507 HGDNVLLSHHTEHTNILKGNMNSVQGKDPSPSST 1540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	27/40 (68%)
		ARID	227..312	CDD:198082	58/84 (69%)
		PHD1_Lid_like	450..495	CDD:277078	27/44 (61%)
		JmjC	624..740	CDD:202224	91/115 (79%)
		zf-C5HC2	830..882	CDD:280996	30/52 (58%)
		PLU-1	896..1229	CDD:285609	95/335 (28%)
		PHD2_KDM5A	1295..1351	CDD:277079	17/65 (26%)
		PHD3_KDM5A_like	1755..1805	CDD:277083
Kdm5d	XP_008771910.1	JmjN	13..54	CDD:128818	27/40 (68%)
		BRIGHT	80..170	CDD:128777	59/89 (66%)
		PHD1_KDM5C_5D	335..380	CDD:277077	27/44 (61%)
		JmjC	510..626	CDD:202224	91/115 (79%)
		zf-C5HC2	716..768	CDD:280996	30/52 (58%)
		PLU-1	781..1104	CDD:285609	95/336 (28%)
		PHD_SF	1192..1252	CDD:304600	17/65 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345170
Domainoid	1	1.000	221	1.000	Domainoid score	I2516
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1244	1.000	Inparanoid score	I166
OMA	1	1.010	-	-		QHG53001
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	1	1.000	-	-		FOG0000761
OrthoInspector	1	1.000	-	-		otm44795
orthoMCL	1	0.900	-	-		OOG6_100617
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X397
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910