DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and jarid2

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	XP_002932734.2	Gene:	jarid2 / 100217357	XenbaseID:	XB-GENE-982166	Length:	1232	Species:	Xenopus tropicalis

Alignment Length:	1013	Identity:	243/1013 - (23%)
Similarity:	383/1013 - (37%)	Gaps:	274/1013 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AKTEADNTTAAN-----SGGGGVGSGTSSGGGASAN------GTATP------------------ 38
            ||.|.|..|..|     |......|||:....|...      .|:.|
Frog   347 AKKELDKATKQNHNKPSSSVHHTISGTTESSNAKTRKQVLSLSTSKPNCAAVLNCVKVNGKLNKK 411

  Fly    39 ------ARRLRTRNSTGNGTNSGSESVKKSNAN-DEPSTPVTPAGATGSHTHAPPGISPAVMERP 96
                  .|:||             |.::.|... :|.|.|          ..|.|.:....:...
Frog   412 TCSREEGRQLR-------------EGLRNSKRRLEEASLP----------AKAQPLLKKIKVSAC 453

  Fly    97 MPSVPMNHASSSVSASKKYHN--------------------SCPHPTPTPAPTG--------HKK 133
            :|.|    .|..::|.|:..|                    |....:|.|.|.|        ::.
Frog   454 LPEV----RSKRLAAEKQVLNGHLKKEVPEKMLERNRPKRASAARSSPVPQPRGKAEDTGCENRS 514

  Fly   134 SVHT-QPHSSNKFDQGKNEE----FHFDTPPECPVFRPTTEEFKNPLAYISKIRSIAEKCGIAKI 193
            :.|| .|..|  .|..|.|:    .......|.||.||:.:||.:||.||..||:..||.|:..:
Frog   515 TSHTDSPQKS--LDSAKTEKNSGRARCTAMCEIPVLRPSAKEFHDPLIYIESIRARVEKYGMCTV 577

  Fly   194 LPPATWSPPFAVDVDKLRFVPRVQRLNELEAKTRVKLNFLDQIAKFWELQGSSL-KIPMVERKAL 257
            :|||.|.|...:: |::|||.::|.:::|..:....:..|..|.|..:.||.:| ::|::....|
Frog   578 IPPADWRPECKLN-DEMRFVTQIQHIHKLGRRWGPNVQRLACIKKHLKSQGITLDELPLIGGCEL 641

  Fly   258 DLYTLHRIVQEEGGMEQTTKDRKWAKVANRMQYPSSKSVGATLKAHYERILHPFEVY----TSGK 318
            ||....:::.|.|||:|.|..:||.|:|:.::.|         |...:|:....|.|    .|..
Frog   642 DLAQFFQLINEMGGMQQVTDLKKWNKLADMLRIP---------KTAQDRLAKLQEAYCQYLLSYD 697

  Fly   319 VLGPTPTSSGSGSTPVKLEDGGGTDYKAHEIPTRQQIAPPNETNTRRSKRFGNSNASCGLSGVTP 383
            .|.|                      :.|:...::.:........::....|:|:.:..|. :.|
Frog   698 SLSP----------------------EEHKKLEKEVLQEKENLEKKKGPLEGHSDNAYKLH-LLP 739

  Fly   384 TTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTTANTRGASQKKG--GEPPALIVDPL 446
            ..:|..|:......:...:..|......|.:|...|.|....:|....:.|.  ||
Frog   740 RYEPKNGLINGVVHRNGLRGKLKEMDVQVKNGRRRLFTQDKESTEEEPEDKSLFGE--------- 795

  Fly   447 MKYICHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKGEWLCPRCVVEEVSKPQEAFGFEQ 511
                .|.|                              |.||
Frog   796 ----LHKC------------------------------IYKG----------------------- 803

  Fly   512 AEREYTLQQFGQMADQFKQEYFRKPVHLVPT-EMVEREFWRIVSSIDEDVTVEYGADLHTMDHGS 575
              |..:|..|.:.|.......|.|.    || ..||:|:|.||...:..|.|..| .:.|..|||
Frog   804 --RSVSLTTFYRTARNVMNMCFNKE----PTVSEVEQEYWHIVEQKNCHVAVHCG-KVDTKTHGS 861

  Fly   576 GFPTKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADISGMNAPWMYVGMCFAAFCW-HNE 639
            |||...:       :.::...|||..||....|||.|:.| :.|:..||:.:||.|:..|| .::
Frog   862 GFPVGKA-------EPFSRHGWNLTVLPNNSGSILRHLGA-VPGVTIPWLNIGMVFSTSCWSRDQ 918

  Fly   640 DHWSYSINYLHWGEPKTWYGVPG---SCAEQFEETMKQAAPELFSSQPDLLHQLV---TIMNPNI 698
            :|..| |:|||.|....||.:|.   |..::...|:.||     :..|.|  |::   .:::|.:
Frog   919 NHLPY-IDYLHTGADCIWYCIPAEEESKLDKVVHTLLQA-----NGTPGL--QMLESNVMISPEV 975

  Fly   699 LMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPADWLKMGRECVNHYSMLRRFC 763
            |....:.|.||.|.:|:||:.||.::.:....||:.:|.|:||...|..||.:...  .|.||..
Frog   976 LCKEGIKVHRTVQKSGQFVVCFPGSFVSKVCCGYSVSETVHFATTQWTSMGFKTAK--EMKRRHI 1038

  Fly   764 V--FSHDELVCKMALEPAKL----TFGIATACYIDMAEMVDTEKKLRKSLLEWGVTRAER----- 817
            .  ||.::|:.::|...||.    |..:.:..   :.|:.|||.:.|:.|.|.|:..:.|
Frog  1039 AKPFSMEKLLYQIATAEAKKENSPTLSVISTL---LRELRDTELRQRQQLFEAGLHSSARYGSHD 1100

  Fly   818 ------------RAFELVNDDERHCQECNTTCFLSAVACECNDKLIVC----LRHYTVLCGCAPE 866
                        |.:..:...||.||.|...|:||.|..| |:.::.|    |||......|...
Frog  1101 IGSSSLDGKKRPRKWLQLETSERRCQICQHLCYLSMVVQE-NENVVFCLECALRHVEKQKSCRGL 1164

  Fly   867 KHTLIYRYTLDEMPLMLQKL--KV--KAHSFERWLSRC 900
            |  |:|||..:::..::.::  ||  |.:|.|.....|
Frog  1165 K--LMYRYDEEQIKSLVNQICGKVPGKNNSNENCPMNC 1200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	20/40 (50%)
		ARID	227..312	CDD:198082	23/85 (27%)
		PHD1_Lid_like	450..495	CDD:277078	5/44 (11%)
		JmjC	624..740	CDD:202224	38/122 (31%)
		zf-C5HC2	830..882	CDD:280996	19/55 (35%)
		PLU-1	896..1229	CDD:285609	1/5 (20%)
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
jarid2	XP_002932734.2	JmjN	544..585	CDD:128818	20/40 (50%)
		ARID_JARD2	608..719	CDD:350634	29/141 (21%)
		JmjC	902..1017	CDD:334913	38/122 (31%)
		zf-C5HC2	1125..1178	CDD:367254	19/55 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020