DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lid and jarid2a

DIOPT Version :9

Sequence 1:	NP_001245908.1	Gene:	lid / 33837	FlyBaseID:	FBgn0031759	Length:	1838	Species:	Drosophila melanogaster
Sequence 2:	XP_001345885.4	Gene:	jarid2a / 100007426	ZFINID:	ZDB-GENE-061218-1	Length:	1171	Species:	Danio rerio

Alignment Length:	972	Identity:	231/972 - (23%)
Similarity:	374/972 - (38%)	Gaps:	231/972 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAKTEADNTTAANSGGGGVGSG------TSSGGGASANGTAT-PARRLRTRNSTGNGTNSGSE- 57
            :|..|...:.| :|||.......      .|.......:||.| |.||...|.|......:|:|
Zfish   323 LSTHTHTHSQT-SNSGKAQTSHAKMQKQVLSPATAGRLSGTDTFPPRRNGLRQSKRQLELAGAEV 386

  Fly    58 SVKKSNANDEPSTPVTPAGATGSHTHAPPGISPAVMERP-------MPSVPMNHASSSVSASKKY 115
            .||:...:..|..  |.:......|.|.|  .||..:||       :......|..:||.|....
Zfish   387 EVKRVKVHVVPLE--TRSRKAAQETQARP--QPAGSQRPKRASAGKLMFTKQMHCKASVLAKNSP 447

  Fly   116 HNS---------CPHPTPTPAPTGHKKSVH----TQPHSSNKFDQGKNEEFHFDTPPECPVFRPT 167
            ..|         .|..:.||..:...|..|    |:|.||...::|:...    ...|.|||.|.
Zfish   448 TTSTRDILRPANSPKLSETPRTSNALKQGHPSNMTEPFSSEPKERGRRSA----EITELPVFYPN 508

  Fly   168 TEEFKNPLAYISKIRSIAEKCGIAKILPPATWSPPFAVDVDKLRFVPRVQRLNELEAKTRVKLNF 232
            |.||.:||.::...|..||..|:.:::|||.|.|...:. :::|||..||.:::|..:....:..
Zfish   509 THEFHDPLTFMELARGQAEAFGLFRVVPPAGWRPECKLK-EEMRFVSYVQHVHKLGRRWGPNVQR 572

  Fly   233 LDQIAKFWELQGSSL-KIPMVERKALDLYTLHRIVQEEGGMEQTTKDRKWAKVANRMQYP-SSKS 295
            |..|.:....||.:: :.|::....|||....:|:.|.|||:|.|..:.|.::|:.:..| |::.
Zfish   573 LACIRRHLRTQGINMEEPPLIGGCELDLARFFQIINEMGGMQQVTDLKTWGRLADLLGIPRSAQD 637

  Fly   296 VGATLKAHYERILHPFEVYTSGKVLGPTPTSSGSGSTPVKLEDGGGTDYKAHEIPTRQQIAPPNE 360
            ..|.|:..|.:.|..::..|..:              ..:||              ::.:|....
Zfish   638 RLAKLQEAYCQYLLSYDSLTPAQ--------------RAQLE--------------KEVLAEKEA 674

  Fly   361 TNTRRSKRFGNSNASCGLSGVTPTTKPSAGVFVKTETKEEFKRDLLSSFNAVNSGGSPLATGTTA 425
            ...|.....|..:.:...:...|..:|..|:                    ||
Zfish   675 LERRNGPLEGQGDIAQHAALQLPRCEPKNGL--------------------VN------------ 707

  Fly   426 NTRGASQKKGGEPPALIVDPLMKYI--CHICNRGDVEESMLLCDGCDDSYHTFCLLPPLTSIPKG 488
               ||..:.|.......:||..|..  ..:..||: ||.|:      ...|
Zfish   708 ---GALHRSGAREHLRELDPTAKSTRQKRLEKRGE-EEGMI------SEQH-------------- 748

  Fly   489 EWLCPRCVVEEVSKPQEAFGFEQAEREYTLQQFGQMADQFKQEYFRKPVHLVPTEMVEREFWRIV 553
                 :|:..              .:.::|..|.:.|.......|.|.   ..|..||:|:||:|
Zfish   749 -----KCIYR--------------GKSFSLTTFFRAARNTMNMCFSKE---PDTAEVEKEYWRLV 791

  Fly   554 SSIDEDVTVEYGADLHTMDHGSGFPTKSSLYLLPGDQEYAESSWNLNNLPLLEDSILGHINADIS 618
            ...:..|.|..|. :.|..||||||...|       :.:::..||||.|.....|||.|:.| :.
Zfish   792 DEKESHVAVHCGR-VDTKTHGSGFPVGKS-------EPFSKHGWNLNVLSNNSGSILRHLGA-VP 847

  Fly   619 GMNAPWMYVGMCFAAFCWHNEDHWSYSINYLHWGEPKTWYGVPG---SCAEQFEETMKQA--APE 678
            |:..||:.:||.|:..||..:.:....|:|||.|....||.:|.   |..::...|:.||  .|.
Zfish   848 GVTIPWLNIGMVFSTSCWCRDQNSLPYIDYLHTGADCIWYCIPAEEKSKLDKVVHTLLQANGTPG 912

  Fly   679 LFSSQPDLLHQLVTIMNPNILMNNRVPVFRTDQHAGEFVITFPRAYHAGFNQGYNFAEAVNFAPA 743
            |     ::|.:.:.| :|.:|....|.|:||.||:|:|::.||..:.|....||:.:|.::||..
Zfish   913 L-----EMLERNIMI-SPEVLRRKGVKVYRTVQHSGQFMVCFPGTFVAKVCCGYSVSETMHFANL 971

  Fly   744 DWLKMGRECVNHYSMLRRFCVFSHDELVCKMALEPAKLTFGIATACYIDMAEMV----------- 797
            .|:|:|.|........|....||.::|:.::            |.|..|..:::
Zfish   972 QWMKLGYEAAKDLKRRRIEEPFSTEKLLYQI------------TTCERDNKQLMTAVSSLFRDLR 1024

  Fly   798 DTEKKLRKSLLEWGV---------------TRAERRAFELVNDDERHCQECNTTCFLSAVACECN 847
            |.|.:.|:.|.|.|:               .|.::|:....:..:|.||.|...|:||.|..| :
Zfish  1025 DAEIRQRRELFEAGLRLSARYGTNCESPTERRKQQRSRFTEDTADRRCQVCQHLCYLSMVVHE-S 1088

  Fly   848 DKLIVCLRHYTVLCGCA---------PEKHTLIYRYTLDEMPLM--------LQKLKVKAHS 892
            |.::.||.       ||         |....:::||:.:::..:        |.|..||..|
Zfish  1089 DNVVFCLE-------CALRYIQKRRSPRGLKMMFRYSEEQLNSLVNRVCGRTLDKAGVKQRS 1143

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lid	NP_001245908.1	JmjN	160..201	CDD:128818	18/40 (45%)
		ARID	227..312	CDD:198082	23/86 (27%)
		PHD1_Lid_like	450..495	CDD:277078	6/46 (13%)
		JmjC	624..740	CDD:202224	38/120 (32%)
		zf-C5HC2	830..882	CDD:280996	16/60 (27%)
		PLU-1	896..1229	CDD:285609
		PHD2_KDM5A	1295..1351	CDD:277079
		PHD3_KDM5A_like	1755..1805	CDD:277083
jarid2a	XP_001345885.4	JmjN	501..542	CDD:301729	18/40 (45%)
		ARID	568..654	CDD:198082	23/85 (27%)
		JmjC	853..968	CDD:202224	38/120 (32%)
		zf-C5HC2	1072..1125	CDD:280996	16/60 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D664180at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10694
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920