DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ifc and degs1

DIOPT Version :9

Sequence 1:	NP_476594.1	Gene:	ifc / 33836	FlyBaseID:	FBgn0001941	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_001007485.1	Gene:	degs1 / 493214	XenbaseID:	XB-GENE-946874	Length:	323	Species:	Xenopus tropicalis

Alignment Length:	318	Identity:	192/318 - (60%)
Similarity:	241/318 - (75%)	Gaps:	0/318 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGQKVSRTDFEWVYTEEPHASRRKIILEKYPQIKKLFGHDPNFKWVAGAMVLTQILALFVVKDLS 65
            ||...:|.|||||||::|||.|||.||.|||:||.|...|.|..|:...|||||::|.::||||.
Frog     1 MGNSAAREDFEWVYTDQPHADRRKEILAKYPEIKSLMKPDHNLIWIVSLMVLTQLVAFYLVKDLD 65

  Fly    66 WSWLIVAAYCFGGIINHSLMLAVHEISHNLAFGHSRPMHNRILGFICNLPIGLPMSISFKKYHLE 130
            |.||:...|..|..|:||:.||:||||||.|||:|:.|.||..|...|||:|||.|:|||:||::
Frog    66 WKWLLFWTYVVGSCISHSMTLAIHEISHNSAFGNSKAMWNRCFGMFANLPLGLPYSVSFKRYHMD 130

  Fly   131 HHRYQGDEAIDTDIPTLLEARLFDTTFGKFLWVCLQPFFYIFRPLIINPKPPTRLEIINTVVQLT 195
            ||||.|.:.:|.||||..|...|.|...|.:|:.|||.||..|||.|||||.|||||||.|||.:
Frog   131 HHRYLGGDGVDVDIPTDFEGWFFCTPLRKLVWIILQPLFYTIRPLCINPKPITRLEIINLVVQFS 195

  Fly   196 FNALIVYFLGWKPLAYLLIGSILAMGLHPVAGHFISEHYMFAKGFETYSYYGPLNWITFNVGYHN 260
            |:|||.|.||.|.|.|:|:||||.:||||::||||:|||||.||.||||||||||::||||||||
Frog   196 FDALIYYTLGGKALFYMLVGSILGLGLHPISGHFIAEHYMFLKGHETYSYYGPLNYLTFNVGYHN 260

  Fly   261 EHHDFPAVPGSRLPEVKRIAKEFYDTMPQHTSWTRVLYDFIMDPAVGPYARVKRRQRG 318
            ||||||:|||..||.|::||.|:||.:|:::||.:|||||:||..:.||:|:||:.:|
Frog   261 EHHDFPSVPGKNLPLVRKIAAEYYDPLPKYSSWVKVLYDFVMDDTLSPYSRMKRKLKG 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ifc	NP_476594.1	PLN02579	3..315	CDD:215316	188/311 (60%)
		Lipid_DES	6..42	CDD:285726	23/35 (66%)
		Delta4-sphingolipid-FADS-like	26..315	CDD:239585	174/288 (60%)
degs1	NP_001007485.1	Lipid_DES	6..42	CDD:369949	23/35 (66%)
		Delta4-sphingolipid-FADS-like	26..315	CDD:239585	174/288 (60%)
		Histidine box-1. /evidence=ECO:0000305	89..93		3/3 (100%)
		Histidine box-2. /evidence=ECO:0000305	128..132		1/3 (33%)
		Histidine box-3. /evidence=ECO:0000305	259..263		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	307	1.000	Domainoid score	I1343
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	432	1.000	Inparanoid score	I1677
OMA	1	1.010	-	-		QHG53934
OrthoDB	1	1.010	-	-		D1255438at2759
OrthoFinder	1	1.000	-	-		FOG0001222
OrthoInspector	1	1.000	-	-		otm47762
Panther	1	1.100	-	-	O	PTHR12879
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R304
SonicParanoid	1	1.000	-	-		X762
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.110