DRSC/TRiP Functional Genomics Resources

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Protein Alignment ifc and Degs2

DIOPT Version :9

Sequence 1:NP_476594.1 Gene:ifc / 33836 FlyBaseID:FBgn0001941 Length:321 Species:Drosophila melanogaster
Sequence 2:NP_001017457.1 Gene:Degs2 / 314438 RGDID:1305023 Length:323 Species:Rattus norvegicus


Alignment Length:315 Identity:184/315 - (58%)
Similarity:227/315 - (72%) Gaps:0/315 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGQKVSRTDFEWVYTEEPHASRRKIILEKYPQIKKLFGHDPNFKWVAGAMVLTQILALFVVKDLS 65
            ||...:|:||||||:::||..|||.:|.|||.||.|...|||.||....|||.|:||.::|:.||
  Rat     1 MGNSAARSDFEWVYSDQPHTQRRKEMLAKYPSIKALMRPDPNIKWTVLGMVLVQVLACWLVRGLS 65

  Fly    66 WSWLIVAAYCFGGIINHSLMLAVHEISHNLAFGHSRPMHNRILGFICNLPIGLPMSISFKKYHLE 130
            |.||:..||.|||.|||||.||:|:||||.|||......||......|||||||.:.||||||::
  Rat    66 WRWLLFWAYAFGGCINHSLTLAIHDISHNTAFGTRCASRNRWFAVFANLPIGLPYATSFKKYHVD 130

  Fly   131 HHRYQGDEAIDTDIPTLLEARLFDTTFGKFLWVCLQPFFYIFRPLIINPKPPTRLEIINTVVQLT 195
            ||||.|.:.:|.||||..|...|.|...|.||:.||||||..|||.:|||..||:||:|.:|||.
  Rat   131 HHRYLGGDGLDVDIPTDFEGWFFCTPARKLLWLVLQPFFYSLRPLYVNPKAVTRMEILNALVQLA 195

  Fly   196 FNALIVYFLGWKPLAYLLIGSILAMGLHPVAGHFISEHYMFAKGFETYSYYGPLNWITFNVGYHN 260
            ||..|....|.|.:.|||..|:|.:||||::|||::|||||.||.|||||||||||||||||||.
  Rat   196 FNVTIFALWGIKAIVYLLASSLLGLGLHPISGHFVAEHYMFLKGHETYSYYGPLNWITFNVGYHV 260

  Fly   261 EHHDFPAVPGSRLPEVKRIAKEFYDTMPQHTSWTRVLYDFIMDPAVGPYARVKRR 315
            ||||||::||..||.|:.||.|:||.:|||.||.:||:||:.:.::|||:||||:
  Rat   261 EHHDFPSIPGCYLPLVRMIAPEYYDHLPQHHSWVKVLWDFVFEDSLGPYSRVKRK 315

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ifcNP_476594.1 PLN02579 3..315 CDD:215316 181/311 (58%)
Lipid_DES 6..42 CDD:285726 20/35 (57%)
Delta4-sphingolipid-FADS-like 26..315 CDD:239585 169/288 (59%)
Degs2NP_001017457.1 Lipid_DES 7..42 CDD:400734 20/34 (59%)
Delta4-sphingolipid-FADS-like 26..315 CDD:239585 169/288 (59%)
Histidine box-1. /evidence=ECO:0000305 89..93 2/3 (67%)
Required for C4-hydroxylase activity. /evidence=ECO:0000250|UniProtKB:Q8R2F2 95..99 2/3 (67%)
Histidine box-2. /evidence=ECO:0000305 128..132 1/3 (33%)
Histidine box-3. /evidence=ECO:0000305 259..263 2/3 (67%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166353214
Domainoid 1 1.000 303 1.000 Domainoid score I1341
eggNOG 1 0.900 - - E1_KOG2987
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H23617
Inparanoid 1 1.050 428 1.000 Inparanoid score I1675
OMA 1 1.010 - - QHG53934
OrthoDB 1 1.010 - - D1255438at2759
OrthoFinder 1 1.000 - - FOG0001222
OrthoInspector 1 1.000 - - otm44727
orthoMCL 1 0.900 - - OOG6_101167
Panther 1 1.100 - - LDO PTHR12879
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X762
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.770

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