DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ifc and dsd1

DIOPT Version :9

Sequence 1:	NP_476594.1	Gene:	ifc / 33836	FlyBaseID:	FBgn0001941	Length:	321	Species:	Drosophila melanogaster
Sequence 2:	NP_596407.1	Gene:	dsd1 / 2541019	PomBaseID:	SPBC3B8.07c	Length:	362	Species:	Schizosaccharomyces pombe

Alignment Length:	323	Identity:	144/323 - (44%)
Similarity:	197/323 - (60%)	Gaps:	18/323 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FEWVYTEEPHASRRKIILEKYPQIKKLFGHDPNFKWVAGAMVLTQILALFVVKD---LSWSWLIV 71
            |.|.||||||.|||..||:.:|:|..|.|::|..||:...:|..|....:::..   |||.:.:
pombe    29 FYWTYTEEPHKSRRAAILKAHPEIASLNGYEPLTKWIVLGVVSLQFTCAYLLSQSSLLSWKFFL- 92

  Fly    72 AAYCFGGIINHSLMLAVHEISHNLAFGHSRPMHNRILGFICNLPIGLPMSISFKKYHLEHHRYQG 136
            .||..|...|.:|.||:||:||||.|  .:.::||......|||:|.|.:.||:.||:|||.|||
pombe    93 TAYFIGAFCNQNLFLAIHELSHNLGF--KKTLYNRAYCLFANLPVGAPFAASFRPYHMEHHAYQG 155

  Fly   137 DEAIDTDIPTLLEARLFDTTFGKFLWVCLQPFFYIFRPLIINPKPPTRLEIINTVVQLTFNALIV 201
            .:.:|||:||..|..|||...||..:...|..||.||||::...|.|.:...|.:||.:|:.|:|
pombe   156 VDGMDTDLPTRAELILFDNVLGKAFFCTFQLLFYAFRPLVVRRLPFTLMHFWNIIVQFSFDYLVV 220

  Fly   202 YFLGWKPLAYLLIGSILAMGLHPVAGHFISEHY------MFAKG------FETYSYYGPLNWITF 254
            .::||:.|||..:.|.||..|||.||||:||||      :.|.|      .||:|||||||:..:
pombe   221 RYVGWRALAYFFMSSFLAGSLHPTAGHFLSEHYNMTRTRLIASGPGKETPLETFSYYGPLNFFVY 285

  Fly   255 NVGYHNEHHDFPAVPGSRLPEVKRIAKEFYDTMPQHTSWTRVLYDFIMDPAVGPYARVKRRQR 317
            |.|||.||||||.|..:|:.:|:.:|.||||.:|...||..::|.||.|..||.:.||||:|:
pombe   286 NAGYHIEHHDFPYVAWTRIGKVRELAPEFYDNIPDCKSWCGIIYQFITDSNVGMWCRVKRKQK 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ifc	NP_476594.1	PLN02579	3..315	CDD:215316	142/319 (45%)
		Lipid_DES	6..42	CDD:285726	17/31 (55%)
		Delta4-sphingolipid-FADS-like	26..315	CDD:239585	131/303 (43%)
dsd1	NP_596407.1	Lipid_DES	27..61	CDD:285726	17/31 (55%)
		PLN02579	28..351	CDD:215316	144/323 (45%)
		Delta4-sphingolipid-FADS-like	45..346	CDD:239585	131/303 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	217	1.000	Domainoid score	I570
eggNOG	1	0.900	-	-		E1_KOG2987
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23617
Inparanoid	1	1.050	296	1.000	Inparanoid score	I619
OMA	1	1.010	-	-		QHG53934
OrthoFinder	1	1.000	-	-		FOG0001222
OrthoInspector	1	1.000	-	-		oto100692
orthoMCL	1	0.900	-	-		OOG6_101167
Panther	1	1.100	-	-	LDO	PTHR12879
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R304
SonicParanoid	1	1.000	-	-		X762
TreeFam	1	0.960	-	-
	14	13.860