Protein Alignment eIF4A and EIF4A3

DIOPT Version :10

• Sequence 1: NP_476595.1
• Gene: eIF4A / 33835
• FlyBaseID: FBgn0001942
• Length: 403
• Species: Drosophila melanogaster
• Sequence 2: NP_055555.1
• Gene: EIF4A3 / 9775
• HGNCID: 18683
• Length: 411
• Species: Homo sapiens
• Alignment Length: 377
• Identity: 263/377 - (69%)
• Similarity: 321/377 - (85%)
• Gaps: 0/377 - (0%)

  Fly    27 EVYDNFDDMNLREELLRGIYGYGFEKPSAIQQRAIIPCVRGRDVIAQAQSGTGKTATFSIAILQQ 91
            :|...||.|.|||:||||||.||||||||||||||...::|||||||:||||||||||||::||.
Human    35 DVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQC 99

  Fly    92 IDTSIRECQALILAPTRELATQIQRVVMALGEYMKVHSHACIGGTNVREDARILESGCHVVVGTP 156
            :|..:||.||||||||||||.|||:.::|||:||.|..|||||||||.||.|.|:.|.|||.|||
Human   100 LDIQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTP 164

  Fly   157 GRVYDMINRKVLRTQYIKLFVLDEADEMLSRGFKDQIQDVFKMLPPDVQVILLSATMPPDVLEVS 221
            |||:|||.|:.|||:.||:.|||||||||::|||:||.||::.|||..||:|:|||:|.::||::
Human   165 GRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMT 229

  Fly   222 RCFMRDPVSILVKKEELTLEGIKQFYVNVKQENWKLGTLCDLYDTLSITQSVIFCNTRRKVDQLT 286
            ..||.||:.||||::||||||||||:|.|::|.||..|||||||||:|||:||||||:||||.||
Human   230 NKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLT 294

  Fly   287 QEMSIHNFTVSAMHGDMEQRDREVIMKQFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPSNRE 351
            ::|...|||||:|||||.|::||.|||:||||:|||||:||:.|||:||.||||:||||||:|||
Human   295 EKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRE 359

  Fly   352 NYIHRIGRGGRFGRKGVAINFITDDDRRILKDIEQFYHTTIEEMPANIADLI 403
            .|||||||.||:|||||||||:.:||.|||:||||:|.|.|:|||.|:||||
Human   360 LYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_476595.1	DEAD-like_helicase_N	6..403	CDD:475120	261/375 (70%)
EIF4A3	NP_055555.1	DEAD-like_helicase_N	35..411	CDD:475120	261/375 (70%)
		Q motif	38..66		21/27 (78%)
		DEAD box. /evidence=ECO:0000305	187..190		2/2 (100%)