Protein Alignment eIF4A and Ddx39a

DIOPT Version :10

• Sequence 1: NP_476595.1
• Gene: eIF4A / 33835
• FlyBaseID: FBgn0001942
• Length: 403
• Species: Drosophila melanogaster
• Sequence 2: NP_446015.2
• Gene: Ddx39a / 89827
• RGDID: 619920
• Length: 427
• Species: Rattus norvegicus
• Alignment Length: 407
• Identity: 151/407 - (37%)
• Similarity: 244/407 - (59%)
• Gaps: 14/407 - (3%)

  Fly     2 DDRNEIPQDG-PASMEPEGVIESTWHEVYDN-FDDMNLREELLRGIYGYGFEKPSAIQQRAIIPC 64
            |:..::||:. ||  .|:..::.::..::.: |.|..|:.||||.|...|||.||.:|...|...
  Rat    16 DEEPQVPQESTPA--PPKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQA 78

  Fly    65 VRGRDVIAQAQSGTGKTATFSIAILQQIDTSIRECQALILAPTRELATQIQRVVMALGEYM-KVH 128
            :.|.||:.||:||.||||.|.:|.||||:....:...|::..|||||.||.:......:|| .|.
  Rat    79 ILGMDVLCQAKSGMGKTAVFVLATLQQIEPINGQVSVLVMCHTRELAFQISKEYERFSKYMPSVK 143

  Fly   129 SHACIGGTNVREDARILESGC-HVVVGTPGRVYDMINRKVLRTQYIKLFVLDEADEMLSR-GFKD 191
            .....||.::::|..:|:..| |||||||||:..::..:.|..:.:|.|||||.|:||.: ..:.
  Rat   144 VSVFFGGLSIKKDEDVLKKNCPHVVVGTPGRILALVRSRSLNLRNVKHFVLDECDKMLEQLDMRR 208

  Fly   192 QIQDVFKMLPPDVQVILLSATMPPDVLEVSRCFMRDPVSILVKKE-ELTLEGIKQFYVNVK--QE 253
            .:|::|::.|.:.|.::.|||:..::..|.|.||:||:.:.|..| :|||.|::|:||.:|  ::
  Rat   209 DVQEIFRLTPHEKQCMMFSATLSKEIRPVCRKFMQDPMEVFVDDETKLTLHGLQQYYVKLKDSEK 273

  Fly   254 NWKLGTLCDLYDTLSITQSVIFCNTRRKVDQLTQEMSIHNFTVSAMHGDMEQRDREVIMKQFRSG 318
            |.|   |.||.|.|...|.|||..:.::...|.|.:...||...|:|..|.|.:|....:||:..
  Rat   274 NRK---LFDLLDVLEFNQVVIFVKSVQRCMALAQLLVEQNFPAIAIHRGMAQEERLSRYQQFKDF 335

  Fly   319 SSRVLITTDLLARGIDVQQVSLVINYDLPSNRENYIHRIGRGGRFGRKGVAINFITDD-DRRILK 382
            ..|:|:.|:|..||:|:::|::|.|||:|.:.:.|:||:.|.||||.||:|:.|::|: |.:||.
  Rat   336 QRRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAVTFVSDENDAKILN 400

  Fly   383 DIEQFYHTTIEEMPANI 399
            |::..:...:.|:|..|
  Rat   401 DVQDRFEVNVAELPEEI 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_476595.1	DEAD-like_helicase_N	6..403	CDD:475120	150/403 (37%)
Ddx39a	NP_446015.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35		6/20 (30%)
		DEADc_DDX39	43..250	CDD:350708	80/206 (39%)
		Q motif	44..72		13/27 (48%)
		DECD box	195..198		2/2 (100%)
		SF2_C_DEAD	261..390	CDD:350174	50/131 (38%)