DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4A and AT1G72730

DIOPT Version :9

Sequence 1:	NP_001245907.1	Gene:	eIF4A / 33835	FlyBaseID:	FBgn0001942	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_177417.1	Gene:	AT1G72730 / 843605	AraportID:	AT1G72730	Length:	414	Species:	Arabidopsis thaliana

Alignment Length:	388	Identity:	263/388 - (67%)
Similarity:	323/388 - (83%)	Gaps:	0/388 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EPEGVIESTWHEVYDNFDDMNLREELLRGIYGYGFEKPSAIQQRAIIPCVRGRDVIAQAQSGTGK 80
            |.|....:.:.||.|:||.|.|:.:||||||.||||||||||||.|||..:|.|||.||||||||
plant    27 EGEETFYTNYDEVCDSFDAMELQPDLLRGIYAYGFEKPSAIQQRGIIPFCKGLDVIQQAQSGTGK 91

  Fly    81 TATFSIAILQQIDTSIRECQALILAPTRELATQIQRVVMALGEYMKVHSHACIGGTNVREDARIL 145
            ||||...:|||:|.|:.:||||:||||||||.||::|:.|||:|:.|.:.||:|||:||||.|:|
plant    92 TATFCSGVLQQLDISLVQCQALVLAPTRELAQQIEKVMRALGDYLGVKAQACVGGTSVREDQRVL 156

  Fly   146 ESGCHVVVGTPGRVYDMINRKVLRTQYIKLFVLDEADEMLSRGFKDQIQDVFKMLPPDVQVILLS 210
            :||.||||||||||:|::.|:.||...||:||||||||||||||||||.|:|::||..|||.:.|
plant   157 QSGVHVVVGTPGRVFDLLRRQSLRADAIKMFVLDEADEMLSRGFKDQIYDIFQLLPSKVQVGVFS 221

  Fly   211 ATMPPDVLEVSRCFMRDPVSILVKKEELTLEGIKQFYVNVKQENWKLGTLCDLYDTLSITQSVIF 275
            |||||:.||::|.||..||.||||::||||||||||||||.:|.|||.||||||:||:|||||||
plant   222 ATMPPEALEITRKFMNKPVRILVKRDELTLEGIKQFYVNVDKEEWKLETLCDLYETLAITQSVIF 286

  Fly   276 CNTRRKVDQLTQEMSIHNFTVSAMHGDMEQRDREVIMKQFRSGSSRVLITTDLLARGIDVQQVSL 340
            .|||||||.||.:|...:.||||.||||:|..|::||::||||||||||||||||||||||||||
plant   287 VNTRRKVDWLTDKMRSRDHTVSATHGDMDQNTRDIIMREFRSGSSRVLITTDLLARGIDVQQVSL 351

  Fly   341 VINYDLPSNRENYIHRIGRGGRFGRKGVAINFITDDDRRILKDIEQFYHTTIEEMPANIADLI 403
            |||:|||:..|||:|||||.||||||||||||:|.:|.|::.||::||:..:||:|:|:|||:
plant   352 VINFDLPTQPENYLHRIGRSGRFGRKGVAINFMTSEDERMMADIQRFYNVVVEELPSNVADLL 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_001245907.1	PTZ00424	6..403	CDD:185609	262/386 (68%)
		DEADc	32..232	CDD:238167	133/199 (67%)
		Helicase_C	254..358	CDD:278689	77/103 (75%)
AT1G72730	NP_177417.1	PTZ00424	28..414	CDD:185609	261/385 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	228	1.000	Domainoid score	I663
eggNOG	1	0.900	-	-		E2759_KOG0327
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I263
OMA	1	1.010	-	-		QHG53631
OrthoDB	1	1.010	-	-		D726081at2759
OrthoFinder	1	1.000	-	-		FOG0000304
OrthoInspector	1	1.000	-	-		otm2465
orthoMCL	1	0.900	-	-		OOG6_101294
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X250
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.880