DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4A and EIF4A1

DIOPT Version :9

Sequence 1:	NP_001245907.1	Gene:	eIF4A / 33835	FlyBaseID:	FBgn0001942	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001327653.1	Gene:	EIF4A1 / 820605	AraportID:	AT3G13920	Length:	419	Species:	Arabidopsis thaliana

Alignment Length:	379	Identity:	255/379 - (67%)
Similarity:	312/379 - (82%)	Gaps:	0/379 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DRNEIPQDGPASMEPEGVIESTWHEVYDNFDDMNLREELLRGIYGYGFEKPSAIQQRAIIPCVRG 67
            |..:..|.....:|.:....:::.:|:::||.|.|:|.||||||.||||||||||||.|:|..:|
plant    16 DARQFDQKLNEVLEGQDEFFTSYDDVHESFDAMGLQENLLRGIYAYGFEKPSAIQQRGIVPFCKG 80

  Fly    68 RDVIAQAQSGTGKTATFSIAILQQIDTSIRECQALILAPTRELATQIQRVVMALGEYMKVHSHAC 132
            .|||.||||||||||||...:|||:|.|:.:||||:||||||||.||::|:.|||:|:.|..|||
plant    81 LDVIQQAQSGTGKTATFCSGVLQQLDFSLIQCQALVLAPTRELAQQIEKVMRALGDYLGVKVHAC 145

  Fly   133 IGGTNVREDARILESGCHVVVGTPGRVYDMINRKVLRTQYIKLFVLDEADEMLSRGFKDQIQDVF 197
            :|||:||||.|||::|.||||||||||:||:.|:.||...||:||||||||||||||||||.|:|
plant   146 VGGTSVREDQRILQAGVHVVVGTPGRVFDMLKRQSLRADNIKMFVLDEADEMLSRGFKDQIYDIF 210

  Fly   198 KMLPPDVQVILLSATMPPDVLEVSRCFMRDPVSILVKKEELTLEGIKQFYVNVKQENWKLGTLCD 262
            ::|||.:||.:.||||||:.||::|.||..||.||||::||||||||||||||::|.|||.||||
plant   211 QLLPPKIQVGVFSATMPPEALEITRKFMSKPVRILVKRDELTLEGIKQFYVNVEKEEWKLETLCD 275

  Fly   263 LYDTLSITQSVIFCNTRRKVDQLTQEMSIHNFTVSAMHGDMEQRDREVIMKQFRSGSSRVLITTD 327
            ||:||:|||||||.|||||||.||.:|...:.||||.||||:|..|::||::|||||||||||||
plant   276 LYETLAITQSVIFVNTRRKVDWLTDKMRSRDHTVSATHGDMDQNTRDIIMREFRSGSSRVLITTD 340

  Fly   328 LLARGIDVQQVSLVINYDLPSNRENYIHRIGRGGRFGRKGVAINFITDDDRRIL 381
            ||||||||||||||||:|||:..|||:|||||.||||||||||||:|.||.|:|
plant   341 LLARGIDVQQVSLVINFDLPTQPENYLHRIGRSGRFGRKGVAINFVTRDDERML 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_001245907.1	PTZ00424	6..403	CDD:185609	254/376 (68%)
		DEADc	32..232	CDD:238167	135/199 (68%)
		Helicase_C	254..358	CDD:278689	77/103 (75%)
EIF4A1	NP_001327653.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	228	1.000	Domainoid score	I663
eggNOG	1	0.900	-	-		E2759_KOG0327
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1487
Inparanoid	1	1.050	544	1.000	Inparanoid score	I263
OMA	1	1.010	-	-		QHG53631
OrthoDB	1	1.010	-	-		D726081at2759
OrthoFinder	1	1.000	-	-		FOG0000304
OrthoInspector	1	1.000	-	-		otm2465
orthoMCL	1	0.900	-	-		OOG6_101294
Panther	1	1.100	-	-	O	PTHR24031
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X250
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840