Protein Alignment eIF4A and pit

DIOPT Version :9

• Sequence 1: NP_001245907.1
• Gene: eIF4A / 33835
• FlyBaseID: FBgn0001942
• Length: 403
• Species: Drosophila melanogaster
• Sequence 2: NP_001287459.1
• Gene: pit / 42595
• FlyBaseID: FBgn0266581
• Length: 680
• Species: Drosophila melanogaster
• Alignment Length: 458
• Identity: 121/458 - (26%)
• Similarity: 220/458 - (48%)
• Gaps: 82/458 - (17%)

  Fly     2 DDRNEIP-------------QDG-PASMEPEGVIESTWHEV-YDNFDDMN-------LREELLRG 44
            |:...:|             |:| ||..:....:||:...: |.:.||.:       :.|..||.
  Fly   137 DEEEPVPAKKTKLLPNKSKAQNGKPAKDDEPFTVESSLAALDYRDSDDRSFASLKGAVSEATLRA 201

  Fly    45 IYGYGFEKPSAIQQRAIIPCVRGRDVIAQAQSGTGKTATFSIAILQQID---------TSIRECQ 100
            |...||.:.:.||.:::.|.::|||::..||:|:|||..|.|..::.|:         |.:
  Fly   202 IKEMGFTEMTEIQSKSLTPLLKGRDLVGAAQTGSGKTLAFLIPAVELINKLRFMPRNGTGV---- 262

  Fly   101 ALILAPTRELATQIQRVVMALGEYMKVHSHA---CIGGTNVREDARILESGCHVVVGTPGRVYDM 162
             :|::|||||:.|...|   |.|.|..|.|.   .:||:|.:.::..|..|.:::|.||||:.|.
  Fly   263 -IIISPTRELSMQTFGV---LKELMAHHHHTYGLVMGGSNRQVESEKLGKGINILVATPGRLLDH 323

  Fly   163 I-NRKVLRTQYIKLFVLDEADEMLSRGFKDQIQDVFKMLPPDVQVILLSATMPPDVLEVSRCFMR 226
            : |......:.::..::||.|.:|..||:::::.:..:||...|.:|.|||....:..:|:..::
  Fly   324 LQNSPDFLYKNLQCLIIDEVDRILEIGFEEELKQIINLLPKRRQTMLFSATQTARIEALSKLALK 388

  Fly   227 -DPVSILV--KKEELTLEGIKQFYVNVKQENWKLGTLCDLYDTLSITQSVIFCNTRRKVDQLTQE 288
             :|:.:.|  .::..|::|::|.|:           :|.....|.:..:.:..|.::||......
  Fly   389 SEPIYVGVHDNQDTATVDGLEQGYI-----------VCPSEKRLLVLFTFLKKNRKKKVMVFFSS 442

  Fly   289 -MSIH---------NFTVSAMHGDMEQRDREVIMKQFRSGSSRVLITTDLLARGIDVQQVSLVIN 343
             ||:.         :..|:::||..:|..|.....||.:..|.:|:.||:.|||:|:.||..::.
  Fly   443 CMSVKYHHELFNYIDLPVTSIHGKQKQTKRTTTFFQFCNAESGILLCTDVAARGLDIPQVDWIVQ 507

  Fly   344 YDLPSNRENYIHRIGRGGR-FGRKGVAINFITDDDRRILKDIEQFYHTTIEEMPAN--------I 399
            ||.|.:...||||:||..| .|..|.|:..:..::...|:      :....::|.|        |
  Fly   508 YDPPDDPREYIHRVGRTARGSGTSGHALLLMRPEELGFLR------YLKAAKVPLNEFEFSWQKI 566

  Fly   400 ADL 402
            ||:
  Fly   567 ADI 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_001245907.1	PTZ00424	6..403	CDD:185609	120/454 (26%)
		DEADc	32..232	CDD:238167	64/220 (29%)
		Helicase_C	254..358	CDD:278689	31/113 (27%)
pit	NP_001287459.1	SrmB	186..677	CDD:223587	110/409 (27%)
		DEADc	187..394	CDD:238167	62/214 (29%)
		HELICc	408..537	CDD:238034	39/139 (28%)
		DUF4217	569..627	CDD:290667	0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451795
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030