DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4A and CG7878

DIOPT Version :9

Sequence 1:	NP_001245907.1	Gene:	eIF4A / 33835	FlyBaseID:	FBgn0001942	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_649767.1	Gene:	CG7878 / 40959	FlyBaseID:	FBgn0037549	Length:	703	Species:	Drosophila melanogaster

Alignment Length:	424	Identity:	143/424 - (33%)
Similarity:	225/424 - (53%)	Gaps:	39/424 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDRNEI-------PQDGPASME-PEGVIESTWHEVYDNFDDMNLREELLRGIYGYGFEKPSAIQQ 58
            ::.|:|       |::|..|.. |..|  .|:.:.:..:.||      |..|...||.|||.||.
  Fly   255 EENNKITVSYVFEPKEGETSPPIPNPV--WTFEQCFAEYPDM------LEEITKMGFSKPSPIQS 311

  Fly    59 RAIIPCVRGRDVIAQAQSGTGKTATFSIAILQQIDTSIRE--------CQALILAPTRELATQIQ 115
            :|....::|.|:|..||:|||||..|.:.  ..|.|..:.        ...|:||||||||.||:
  Fly   312 QAWPILLQGHDMIGIAQTGTGKTLAFLLP--GMIHTEYQSTPRGTRGGANVLVLAPTRELALQIE 374

  Fly   116 RVVMALGEY----MKVHSHACI-GGTNVREDARILESGCHVVVGTPGRVYDMINRKVLRTQYIKL 175
               |.:.:|    ||.   .|: ||.|.......||.|..:::.||||:.|:|...|:....|..
  Fly   375 ---MEVKKYSFRGMKA---VCVYGGGNRNMQISDLERGAEIIICTPGRLNDLIMANVIDVSTITY 433

  Fly   176 FVLDEADEMLSRGFKDQIQDVFKMLPPDVQVILLSATMPPDVLEVSRCFMRDPVSILVKKEEL-T 239
            .||||||.||..||:.||:.|...:.||.|.|:.|||.||.|..:::.:|::|:.:.|...:| .
  Fly   434 LVLDEADRMLDMGFEPQIRKVMLDIRPDRQTIMTSATWPPGVRRLAQSYMKNPIQVCVGSLDLAA 498

  Fly   240 LEGIKQFYVNVKQENWKLGTLCDLYDTLSITQS-VIFCNTRRKVDQLTQEMSIHNFTVSAMHGDM 303
            ...:||....::.:..|..|:......:|.|.. :|||..:.:.|.|:.|:::..|....:||:.
  Fly   499 THSVKQIIKLMEDDMDKFNTITSFVKNMSSTDKIIIFCGRKVRADDLSSELTLDGFMTQCIHGNR 563

  Fly   304 EQRDREVIMKQFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPSNRENYIHRIGRGGRFGRKGV 368
            :|.|||..:...:||..|:|:.||:.:||:|::.::.|||||.|.|.|.|:||:||.||.||:|.
  Fly   564 DQMDREQAIADIKSGVVRILVATDVASRGLDIEDITHVINYDFPHNIEEYVHRVGRTGRAGRQGT 628

  Fly   369 AINFITDDDRRILKDIEQFYHTTIEEMPANIADL 402
            :|:|.|.:|..:.|::.:......:|:|..:.::
  Fly   629 SISFFTREDWAMAKELIEILQEAEQEVPDELHNM 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_001245907.1	PTZ00424	6..403	CDD:185609	142/420 (34%)
		DEADc	32..232	CDD:238167	80/212 (38%)
		Helicase_C	254..358	CDD:278689	37/104 (36%)
CG7878	NP_649767.1	KH-I	92..150	CDD:238053
		DEADc	288..489	CDD:238167	80/214 (37%)
		DEXDc	298..505	CDD:214692	80/214 (37%)
		Helicase_C	514..624	CDD:278689	41/109 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451500
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840