DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4A and eif4a1a

DIOPT Version :9

Sequence 1:	NP_001245907.1	Gene:	eIF4A / 33835	FlyBaseID:	FBgn0001942	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_938180.1	Gene:	eif4a1a / 386634	ZFINID:	ZDB-GENE-031030-2	Length:	406	Species:	Danio rerio

Alignment Length:	404	Identity:	300/404 - (74%)
Similarity:	353/404 - (87%)	Gaps:	5/404 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDRNEIPQD-GPASMEPEGVIESTWHEVYDNFDDMNLREELLRGIYGYGFEKPSAIQQRAIIPCV 65
            :||   |:| ||..|||:|||||.|.|:.|:||||||||.||||||.||||||||||||||:||:
Zfish     6 EDR---PRDNGPEGMEPDGVIESNWKEIVDSFDDMNLREALLRGIYAYGFEKPSAIQQRAILPCI 67

  Fly    66 RGRDVIAQAQSGTGKTATFSIAILQQIDTSIRECQALILAPTRELATQIQRVVMALGEYMKVHSH 130
            :|.||||||||||||||||:|:||||||..::..||::||||||||.|||:||:|||:||....|
Zfish    68 KGYDVIAQAQSGTGKTATFAISILQQIDVELKATQAMVLAPTRELAQQIQKVVLALGDYMGATCH 132

  Fly   131 ACIGGTNVREDARILESGC-HVVVGTPGRVYDMINRKVLRTQYIKLFVLDEADEMLSRGFKDQIQ 194
            |||||||||.|.:.|::.. |:||||||||:||:||:.|..:|||:|.||||||||||||||||.
Zfish   133 ACIGGTNVRNDVQKLQADVPHIVVGTPGRVFDMLNRRYLSPKYIKMFALDEADEMLSRGFKDQIY 197

  Fly   195 DVFKMLPPDVQVILLSATMPPDVLEVSRCFMRDPVSILVKKEELTLEGIKQFYVNVKQENWKLGT 259
            ::|:.|..|.||||||||||.:||||:..||||||.|||||||||||||:|||:||::|.|||.|
Zfish   198 EIFQKLATDTQVILLSATMPQEVLEVTTKFMRDPVRILVKKEELTLEGIRQFYINVEKEEWKLDT 262

  Fly   260 LCDLYDTLSITQSVIFCNTRRKVDQLTQEMSIHNFTVSAMHGDMEQRDREVIMKQFRSGSSRVLI 324
            |||||:||:|||:|||.|||||||.||::|...:|||||:||||||::|:||||:||||||||||
Zfish   263 LCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSALHGDMEQKERDVIMKEFRSGSSRVLI 327

  Fly   325 TTDLLARGIDVQQVSLVINYDLPSNRENYIHRIGRGGRFGRKGVAINFITDDDRRILKDIEQFYH 389
            |||||||||||||||||||||||:|||||||||||||||||||||||.||:||:|.|:|||.||:
Zfish   328 TTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMITEDDKRTLRDIETFYN 392

  Fly   390 TTIEEMPANIADLI 403
            ||:||||.|:||||
Zfish   393 TTVEEMPMNVADLI 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_001245907.1	PTZ00424	6..403	CDD:185609	296/398 (74%)
		DEADc	32..232	CDD:238167	143/200 (72%)
		Helicase_C	254..358	CDD:278689	84/103 (82%)
eif4a1a	NP_938180.1	PTZ00424	20..406	CDD:185609	289/385 (75%)
		DEADc	34..235	CDD:238167	143/200 (72%)
		HELICc	246..361	CDD:238034	91/114 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2383
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	606	1.000	Inparanoid score	I896
OMA	1	1.010	-	-		QHG53631
OrthoDB	1	1.010	-	-		D321438at33208
OrthoFinder	1	1.000	-	-		FOG0000304
OrthoInspector	1	1.000	-	-		otm24646
orthoMCL	1	0.900	-	-		OOG6_101294
Panther	1	1.100	-	-	O	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R594
SonicParanoid	1	1.000	-	-		X250
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010