DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4A and CG5800

DIOPT Version :9

Sequence 1:	NP_001245907.1	Gene:	eIF4A / 33835	FlyBaseID:	FBgn0001942	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_573230.1	Gene:	CG5800 / 32742	FlyBaseID:	FBgn0030855	Length:	826	Species:	Drosophila melanogaster

Alignment Length:	434	Identity:	112/434 - (25%)
Similarity:	200/434 - (46%)	Gaps:	65/434 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RNEIPQDGPASMEPE--------GVIESTWHEVYDNFDDMNLREELLRGIYGYGFEKPSAIQQRA 60
            |.||.:...|:.|.|        ..|::|   ....|....|.::..:.:....|..|:.:|:.:
  Fly    41 RQEINKSRLAATEAEIQDLKTKYAEIDAT---AIKKFAQFPLSKKTQKALAESKFVHPTQVQRDS 102

  Fly    61 IIPCVRGRDVIAQAQSGTGKTATFSIAILQQID----TSIRECQALILAPTRELATQIQRVVMAL 121
            |.|.::|:||:..|.:|:|||..|.|.:|:.:.    :......|:|::||||||.||...:..:
  Fly   103 IGPALQGKDVLGAAITGSGKTLAFLIPVLEHLFMNKWSRTDGVGAIIISPTRELAYQIFETLKKV 167

  Fly   122 GEYMKVHSHACIGGTNVREDARILESGCHVVVGTPGRVYD-MINRKVLRTQYIKLFVLDEADEML 185
            |::....:...|||.|::.:...::. |::::.||||:.. |....:..|..:::.||||||..|
  Fly   168 GKHHDFSAGLIIGGKNLKFERTRMDQ-CNILICTPGRLLQHMDENPLFNTSTMEMLVLDEADRCL 231

  Fly   186 SRGFKDQIQDVFKMLPPDVQVILLSATMPPDVLEVSRCFMRDPV-------------SILVKKEE 237
            ..||:..:..:.:..||..|.:|.|||....|.:::|..::|||             |...||..
  Fly   232 DMGFQKTLNSIIENFPPVRQTLLFSATQTNTVQDLARLNLKDPVYVGYGGATPREEPSASTKKTP 296

  Fly   238 LTL-----EGIKQFYVNVKQENWKLGTLCDLYDTLSITQSVIFCNTRRK----VDQLTQEMSIHN 293
            .|.     |.::|.||           :.:|.|.:::..|.|..:.::|    |....|...::.
  Fly   297 NTAVLAVPELLQQSYV-----------VLNLEDKITMLWSFIKNHLKQKIIVFVASCKQAKYLYE 350

  Fly   294 F--------TVSAMHGDMEQRDREVIMKQFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPSNR 350
            .        .:.|::|.:.|..|..|.:.|...|..|:.:||:.:||:|...|:.|:..|.|.:.
  Fly   351 IFCKLRPGSPLLALYGTLHQDRRIAIYEDFLRKSHVVMFSTDVASRGLDFPAVNWVVQLDCPEDV 415

  Fly   351 ENYIHRIGRGGRFGRKGVAINFITDDDRRILKDIEQFYHTTIEE 394
            ..||||.||..|...:|..:..:|..:       |::..:.::|
  Fly   416 SQYIHRAGRSARNKTRGECLLVLTPSE-------EEYMISALKE 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_001245907.1	PTZ00424	6..403	CDD:185609	111/432 (26%)
		DEADc	32..232	CDD:238167	62/217 (29%)
		Helicase_C	254..358	CDD:278689	28/115 (24%)
CG5800	NP_573230.1	PRK01297	2..471	CDD:234938	112/434 (26%)
		DEADc	74..277	CDD:238167	61/203 (30%)
		HELICc	311..437	CDD:238034	34/136 (25%)
		DUF4217	474..530	CDD:290667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451449
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940