DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4A and CG32344

DIOPT Version :9

Sequence 1:	NP_001245907.1	Gene:	eIF4A / 33835	FlyBaseID:	FBgn0001942	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_612028.4	Gene:	CG32344 / 326208	FlyBaseID:	FBgn0052344	Length:	827	Species:	Drosophila melanogaster

Alignment Length:	383	Identity:	115/383 - (30%)
Similarity:	199/383 - (51%)	Gaps:	28/383 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 FDDMNLREELLRGIYGYGFEKPSAIQQRAIIPCVRGRDVIAQAQSGTGKTATFSIAILQQIDTSI 96
            |..|.|..||::||...|::.|:.||::.|...:.||||:|.|::|:||||.|.|.:.:::..
  Fly    41 FQSMGLGFELIKGITKRGYKVPTPIQRKTIPLILEGRDVVAMAKTGSGKTACFLIPLFEKLQR-- 103

  Fly    97 RE----CQALILAPTRELATQIQRVVMALGEYMKVHSHACIGGTNVREDARILESGCHVVVGTPG 157
            ||    .:||||:||||||.|..:.:..||.:|::.|...:||.::......:.:...|:|.|||
  Fly   104 REPTKGARALILSPTRELAVQTYKFIKELGRFMELKSILVLGGDSMDSQFSAIHTCPDVIVATPG 168

  Fly   158 RVYDMINRKVLRTQYIKLFVLDEADEMLSRGFKDQIQDVFKMLPPDVQVILLSATMPPDVLEVSR 222
            |...:.....|:...|:..|.||||.:...||.:|:.:....||...|.::.|||:|..::|.:|
  Fly   169 RFLHLCVEMDLKLNSIEYVVFDEADRLFEMGFGEQLNETLHRLPSSRQTVMFSATLPKLLVEFAR 233

  Fly   223 CFMRDPVSILVKKEELTLEGIKQFYVNVKQENWKLGTLCDLYDTLSI---------TQSVIFCNT 278
            ..:.|||.|.:..|....:.:...::..:.:        |.|..|.:         :|:|:|..|
  Fly   234 AGLNDPVLIRLDVESKLPDALALKFLYCRPD--------DRYTALVVLLKYVIPVQSQTVVFAGT 290

  Fly   279 RRKVDQLTQEMSIHNFTVSAMHGDMEQRDREVIMKQFRSGSSRVLITTDLLARGIDVQQVSLVIN 343
            :..|:.::..::....:.::::..::...|::...:|.:....|||.||:.|||||:..:..|:|
  Fly   291 QHHVELISYILTEAGISNASVYSSLDPAARKINTAKFVNKKVSVLIVTDVAARGIDIPSLDFVVN 355

  Fly   344 YDLPSNRENYIHRIGRGGRFGRKGVAINFITDDDRRILKDIEQFYHTTIEEMPANIAD 401
            ...|...:.::||:||..|.||.|.|.:.::.||...|.|:..|.:     .|.||.|
  Fly   356 LHFPGKPKLFVHRVGRCARAGRTGTAYSIVSTDDTAHLLDLHLFLN-----RPFNIHD 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_001245907.1	PTZ00424	6..403	CDD:185609	115/383 (30%)
		DEADc	32..232	CDD:238167	72/203 (35%)
		Helicase_C	254..358	CDD:278689	25/112 (22%)
CG32344	NP_612028.4	DEADc	41..243	CDD:238167	72/203 (35%)
		DEXDc	54..243	CDD:214692	66/190 (35%)
		HELICc	263..384	CDD:238034	32/128 (25%)
		DBP10CT	666..721	CDD:285373
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451647
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940