Protein Alignment eIF4A and Eif4a1

DIOPT Version :9

• Sequence 1: NP_001245907.1
• Gene: eIF4A / 33835
• FlyBaseID: FBgn0001942
• Length: 403
• Species: Drosophila melanogaster
• Sequence 2: XP_006246686.1
• Gene: Eif4a1 / 287436
• RGDID: 735141
• Length: 411
• Species: Rattus norvegicus
• Alignment Length: 395
• Identity: 292/395 - (73%)
• Similarity: 349/395 - (88%)
• Gaps: 1/395 - (0%)

  Fly    10 DGPASMEPEGVIESTWHEVYDNFDDMNLREELLRGIYGYGFEKPSAIQQRAIIPCVRGRDVIAQA 74
            :||..|||||||||.|:|:.|:||||||.|.||||||.||||||||||||||:||::|.||||||
  Rat    17 NGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIKGYDVIAQA 81

  Fly    75 QSGTGKTATFSIAILQQIDTSIRECQALILAPTRELATQIQRVVMALGEYMKVHSHACIGGTNVR 139
            ||||||||||:|:|||||:..::..|||:||||||||.|||:||||||:||....||||||||||
  Rat    82 QSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHACIGGTNVR 146

  Fly   140 EDARILE-SGCHVVVGTPGRVYDMINRKVLRTQYIKLFVLDEADEMLSRGFKDQIQDVFKMLPPD 203
            .:.:.|: ...|::|||||||:||:||:.|..:|||:||||||||||||||||||.|:|:.|..:
  Rat   147 AEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYDIFQKLNSN 211

  Fly   204 VQVILLSATMPPDVLEVSRCFMRDPVSILVKKEELTLEGIKQFYVNVKQENWKLGTLCDLYDTLS 268
            .||:|||||||.|||||::.|||||:.|||||||||||||:|||:||::|.|||.||||||:||:
  Rat   212 TQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTLCDLYETLT 276

  Fly   269 ITQSVIFCNTRRKVDQLTQEMSIHNFTVSAMHGDMEQRDREVIMKQFRSGSSRVLITTDLLARGI 333
            |||:|||.|||||||.||::|...:||||||||||:|::|:|||::|||||||||||||||||||
  Rat   277 ITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGI 341

  Fly   334 DVQQVSLVINYDLPSNRENYIHRIGRGGRFGRKGVAINFITDDDRRILKDIEQFYHTTIEEMPAN 398
            ||||||||||||||:|||||||||||||||||||||||.:|::|:|.|:|||.||:|:|||||.|
  Rat   342 DVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLN 406

  Fly   399 IADLI 403
            :||||
  Rat   407 VADLI 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_001245907.1	PTZ00424	6..403	CDD:185609	290/393 (74%)
		DEADc	32..232	CDD:238167	141/200 (71%)
		Helicase_C	254..358	CDD:278689	83/103 (81%)
Eif4a1	XP_006246686.1	PTZ00424	25..411	CDD:185609	285/385 (74%)
		DEADc	39..240	CDD:238167	141/200 (71%)
		HELICc	251..366	CDD:238034	90/114 (79%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353702
Domainoid	1	1.000	230	1.000	Domainoid score	I2365
eggNOG	1	0.900	-	-		E2759_KOG0327
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	604	1.000	Inparanoid score	I903
OMA	1	1.010	-	-		QHG53631
OrthoDB	1	1.010	-	-		D321438at33208
OrthoFinder	1	1.000	-	-		FOG0000304
OrthoInspector	1	1.000	-	-		otm45517
orthoMCL	1	0.900	-	-		OOG6_101294
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X250
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810