DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4A and SPAC1006.07

DIOPT Version :9

Sequence 1:	NP_001245907.1	Gene:	eIF4A / 33835	FlyBaseID:	FBgn0001942	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_594854.1	Gene:	SPAC1006.07 / 2542948	PomBaseID:	SPAC1006.07	Length:	392	Species:	Schizosaccharomyces pombe

Alignment Length:	386	Identity:	281/386 - (72%)
Similarity:	341/386 - (88%)	Gaps:	0/386 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EGVIESTWHEVYDNFDDMNLREELLRGIYGYGFEKPSAIQQRAIIPCVRGRDVIAQAQSGTGKTA 82
            :.|||:.:.||.|.||||||:.|||||||.||||:|||||||||:|.:..|||:|||||||||||
pombe     7 DSVIETNYDEVIDTFDDMNLKPELLRGIYAYGFERPSAIQQRAIMPILGERDVLAQAQSGTGKTA 71

  Fly    83 TFSIAILQQIDTSIRECQALILAPTRELATQIQRVVMALGEYMKVHSHACIGGTNVREDARILES 147
            ||||::||:||||:::|||||||||||||.|||:||:|||:.|.|..|||||||.||:|...|::
pombe    72 TFSISVLQKIDTSLKQCQALILAPTRELAQQIQKVVVALGDLMNVECHACIGGTLVRDDMAALQA 136

  Fly   148 GCHVVVGTPGRVYDMINRKVLRTQYIKLFVLDEADEMLSRGFKDQIQDVFKMLPPDVQVILLSAT 212
            |.||||||||||:|||.|:.|.|..:::||||||||||||||||||.|:|::|||..||:|||||
pombe   137 GVHVVVGTPGRVHDMIQRRALPTDAVQMFVLDEADEMLSRGFKDQIYDIFQLLPPTAQVVLLSAT 201

  Fly   213 MPPDVLEVSRCFMRDPVSILVKKEELTLEGIKQFYVNVKQENWKLGTLCDLYDTLSITQSVIFCN 277
            ||.|||||:..|||||:.|||||:||||||||||||.|::|.|||.||||||:|:::||:|||||
pombe   202 MPQDVLEVTTKFMRDPIRILVKKDELTLEGIKQFYVAVEKEEWKLDTLCDLYETVTVTQAVIFCN 266

  Fly   278 TRRKVDQLTQEMSIHNFTVSAMHGDMEQRDREVIMKQFRSGSSRVLITTDLLARGIDVQQVSLVI 342
            ||||||.||::::..:||||:|||||:|..|:.:|.:||:||||:||||||||||||||||||||
pombe   267 TRRKVDWLTEQLTERDFTVSSMHGDMDQAQRDTLMHEFRTGSSRILITTDLLARGIDVQQVSLVI 331

  Fly   343 NYDLPSNRENYIHRIGRGGRFGRKGVAINFITDDDRRILKDIEQFYHTTIEEMPANIADLI 403
            |||||:||||||||||||||||||||:|||:|:||.|::::|||||:|.|||||.||||||
pombe   332 NYDLPANRENYIHRIGRGGRFGRKGVSINFVTNDDVRMMREIEQFYNTHIEEMPMNIADLI 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_001245907.1	PTZ00424	6..403	CDD:185609	279/384 (73%)
		DEADc	32..232	CDD:238167	144/199 (72%)
		Helicase_C	254..358	CDD:278689	76/103 (74%)
SPAC1006.07	NP_594854.1	PTZ00424	7..392	CDD:185609	279/384 (73%)
		DEADc	21..221	CDD:238167	144/199 (72%)
		HELICc	232..347	CDD:238034	84/114 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	239	1.000	Domainoid score	I465
eggNOG	1	0.900	-	-		E2759_KOG0327
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	578	1.000	Inparanoid score	I171
OMA	1	1.010	-	-		QHG53631
OrthoFinder	1	1.000	-	-		FOG0000304
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101294
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R594
SonicParanoid	1	1.000	-	-		X250
TreeFam	1	0.960	-	-
	12	11.860