DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4A and EIF4A1

DIOPT Version :9

Sequence 1:	NP_001245907.1	Gene:	eIF4A / 33835	FlyBaseID:	FBgn0001942	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001407.1	Gene:	EIF4A1 / 1973	HGNCID:	3282	Length:	406	Species:	Homo sapiens

Alignment Length:	403	Identity:	294/403 - (72%)
Similarity:	352/403 - (87%)	Gaps:	3/403 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DDRNEIPQDGPASMEPEGVIESTWHEVYDNFDDMNLREELLRGIYGYGFEKPSAIQQRAIIPCVR 66
            |.|:.  .:||..|||||||||.|:|:.|:||||||.|.||||||.||||||||||||||:||::
Human     6 DSRSR--DNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQRAILPCIK 68

  Fly    67 GRDVIAQAQSGTGKTATFSIAILQQIDTSIRECQALILAPTRELATQIQRVVMALGEYMKVHSHA 131
            |.||||||||||||||||:|:|||||:..::..|||:||||||||.|||:||||||:||....||
Human    69 GYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVVMALGDYMGASCHA 133

  Fly   132 CIGGTNVREDARILE-SGCHVVVGTPGRVYDMINRKVLRTQYIKLFVLDEADEMLSRGFKDQIQD 195
            ||||||||.:.:.|: ...|::|||||||:||:||:.|..:|||:||||||||||||||||||.|
Human   134 CIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFVLDEADEMLSRGFKDQIYD 198

  Fly   196 VFKMLPPDVQVILLSATMPPDVLEVSRCFMRDPVSILVKKEELTLEGIKQFYVNVKQENWKLGTL 260
            :|:.|..:.||:|||||||.|||||::.|||||:.|||||||||||||:|||:||::|.|||.||
Human   199 IFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEELTLEGIRQFYINVEREEWKLDTL 263

  Fly   261 CDLYDTLSITQSVIFCNTRRKVDQLTQEMSIHNFTVSAMHGDMEQRDREVIMKQFRSGSSRVLIT 325
            ||||:||:|||:|||.|||||||.||::|...:||||||||||:|::|:|||::|||||||||||
Human   264 CDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVSAMHGDMDQKERDVIMREFRSGSSRVLIT 328

  Fly   326 TDLLARGIDVQQVSLVINYDLPSNRENYIHRIGRGGRFGRKGVAINFITDDDRRILKDIEQFYHT 390
            ||||||||||||||||||||||:|||||||||||||||||||||||.:|::|:|.|:|||.||:|
Human   329 TDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINMVTEEDKRTLRDIETFYNT 393

  Fly   391 TIEEMPANIADLI 403
            :|||||.|:||||
Human   394 SIEEMPLNVADLI 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_001245907.1	PTZ00424	6..403	CDD:185609	290/397 (73%)
		DEADc	32..232	CDD:238167	141/200 (71%)
		Helicase_C	254..358	CDD:278689	83/103 (81%)
EIF4A1	NP_001407.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21		7/16 (44%)
		PTZ00424	20..406	CDD:185609	285/385 (74%)
		Q motif	32..60		23/27 (85%)
		DEAD box	182..185		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159651
Domainoid	1	1.000	230	1.000	Domainoid score	I2459
eggNOG	1	0.900	-	-		E2759_KOG0327
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	604	1.000	Inparanoid score	I948
Isobase	1	0.950	-	0	Normalized mean entropy	S157
OMA	1	1.010	-	-		QHG53631
OrthoDB	1	1.010	-	-		D321438at33208
OrthoFinder	1	1.000	-	-		FOG0000304
OrthoInspector	1	1.000	-	-		otm41400
orthoMCL	1	0.900	-	-		OOG6_101294
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R594
SonicParanoid	1	1.000	-	-		X250
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.790