DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4A and F57B9.3

DIOPT Version :9

Sequence 1:	NP_001245907.1	Gene:	eIF4A / 33835	FlyBaseID:	FBgn0001942	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_498514.2	Gene:	F57B9.3 / 186440	WormBaseID:	WBGene00018997	Length:	394	Species:	Caenorhabditis elegans

Alignment Length:	382	Identity:	196/382 - (51%)
Similarity:	268/382 - (70%)	Gaps:	9/382 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ESTWHEVYDNFDDMNLREELLRGIYGYGFEKPSAIQQRAIIPCVRGRDVIAQAQSGTGKTATFSI 86
            |..:.||.::||||.|:|||||||||:|||||||||:.|:.||..|:||..|:|:|:|||....|
Worm    19 EGNYDEVVESFDDMELKEELLRGIYGFGFEKPSAIQKSAVAPCTTGKDVTIQSQAGSGKTVISLI 83

  Fly    87 AILQQIDTSIRECQALILAPTRELATQIQRVVMALGEYMKVHSHACIGGTNVREDARILESGCHV 151
            .|||.||......|.::|||.|.:|.:....:.:||..:.|:: .|:|.....|:.:|    .||
Worm    84 DILQGIDCEDAHLQVILLAPQRGMAQRAHEQLKSLGRNLNVNA-TCLGFDTTAENDKI----SHV 143

  Fly   152 VVGTPGRVYDMINRKVLRTQYIKLFVLDEADEMLSRGFKDQIQDVFKMLPPDVQVILLSATMPPD 216
            ::|||   .|.::.....|..||:|||||||||||:||||||.:||:.:|.||||:|||||||.:
Worm   144 LMGTP---KDFLSNIPSDTSRIKMFVLDEADEMLSKGFKDQIYEVFRSMPQDVQVVLLSATMPSE 205

  Fly   217 VLEVSRCFMRDPVSILVKKEELTLEGIKQFYVNVKQENWKLGTLCDLYDTLSITQSVIFCNTRRK 281
            ||:|:..|||||:.|||||:|||||||:|||:||:::.||...||||..|...||::|||||||:
Worm   206 VLDVTNRFMRDPIRILVKKDELTLEGIRQFYINVQKDEWKFNCLCDLLKTSRETQALIFCNTRRR 270

  Fly   282 VDQLTQEMSIHNFTVSAMHGDMEQRDREVIMKQFRSGSSRVLITTDLLARGIDVQQVSLVINYDL 346
            |.|||:::......||..||:||..:||.::|.|.|.::|||:||||:|||::::: ||:||||:
Worm   271 VTQLTEQLMSIPIKVSCFHGNMEHNEREDMVKDFNSRNTRVLVTTDLMARGMNIRK-SLIINYDV 334

  Fly   347 PSNRENYIHRIGRGGRFGRKGVAINFITDDDRRILKDIEQFYHTTIEEMPANIADLI 403
            ..|.|||:.|.||.|.||.||:.|:|.|::|...||.||..|.|.|||||.:..:.:
Worm   335 SGNMENYMLRNGRQGNFGSKGLPISFFTENDISDLKKIENHYSTRIEEMPESFLEYL 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4A	NP_001245907.1	PTZ00424	6..403	CDD:185609	196/380 (52%)
		DEADc	32..232	CDD:238167	102/199 (51%)
		Helicase_C	254..358	CDD:278689	52/103 (50%)
F57B9.3	NP_498514.2	PTZ00424	19..391	CDD:185609	196/380 (52%)
		P-loop_NTPase	29..221	CDD:304359	102/199 (51%)
		Helicase_C	243..352	CDD:278689	55/109 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I7066
eggNOG	1	0.900	-	-		E2759_KOG0327
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53631
OrthoDB	1	1.010	-	-		D321438at33208
OrthoFinder	1	1.000	-	-		FOG0000304
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.930